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View Structure Prediction Details

Protein: HMT1
Organism: Saccharomyces cerevisiae
Length: 348 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HMT1.

Description E-value Query
Range		 Subject
Range
gi|149056004 - gi|149056004|gb|EDM07435.1| heterogeneous nuclear ribonucleoproteins methyltransferase-like 2 (S. ce...
ANM1_MOUSE - Protein arginine N-methyltransferase 1 OS=Mus musculus GN=Prmt1 PE=1 SV=1
 2.0E-98 [2..341] [36..369]
gi|161789011, gi... - gi|7453575|gb|AAF62893.1|AF222689_1 protein arginine N-methyltransferase 1-variant 2 [Homo sapiens],...
 6.0E-98 [2..341] [26..359]
gi|74147295, gi|... - gi|74147295|dbj|BAE27538.1| unnamed protein product [Mus musculus], gi|7141328|gb|AAF37293.1|AF23271...
ANM1_RAT - Protein arginine N-methyltransferase 1 OS=Rattus norvegicus GN=Prmt1 PE=1 SV=1
gi|55716105 - gb|AAH86158.1| Unknown (protein for MGC:98592) [Xenopus laevis]
 1.0E-97 [2..341] [18..351]
HMT1 - Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hn...
gi|151946425 - gi|151946425|gb|EDN64647.1| arginine methyltransferase [Saccharomyces cerevisiae YJM789]
gi|190408799 - gi|190408799|gb|EDV12064.1| arginine methyltransferase [Saccharomyces cerevisiae RM11-1a]
HMT1_YEAST - Protein arginine N-methyltransferase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=H...
 7.0E-95 [1..348] [1..348]

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Predicted Domain #1
Region A:
Residues: [1-165] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKTAVKDSA TEKTKLSESE QHYFNSYDHY GIHEEMLQDT VRTLSYRNAI IQNKDLFKDK  60
   61 IVLDVGCGTG ILSMFAAKHG AKHVIGVDMS SIIEMAKELV ELNGFSDKIT LLRGKLEDVH 120
  121 LPFPKVDIII SEWMGYFLLY ESMMDTVLYA RDHYLVEGGL IFPDK

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [260-273] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IVFPAPKGKR PVEF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10090.69897
Match: 1g6q1_
Description: Arginine methyltransferase, HMT1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein-arginine N-methyltransferase activity 5.52520020727046 bayes_pls_golite062009
arginine N-methyltransferase activity 5.52520020727046 bayes_pls_golite062009
protein methyltransferase activity 5.03267617653315 bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity 4.4632173842967 bayes_pls_golite062009
histone methyltransferase activity (H4-R3 specific) 4.42061797259061 bayes_pls_golite062009
histone methyltransferase activity 4.40911163698179 bayes_pls_golite062009
protein-arginine omega-N monomethyltransferase activity 4.39379274790202 bayes_pls_golite062009
methyltransferase activity 4.15445027778357 bayes_pls_golite062009
N-methyltransferase activity 4.07806017452628 bayes_pls_golite062009
transferase activity, transferring one-carbon groups 4.07153733729662 bayes_pls_golite062009
protein-arginine omega-N asymmetric methyltransferase activity 3.55785970363721 bayes_pls_golite062009
protein-arginine omega-N symmetric methyltransferase activity 3.42560739702664 bayes_pls_golite062009
transferase activity 2.926540904444 bayes_pls_golite062009
histone-arginine N-methyltransferase activity 2.86617323549909 bayes_pls_golite062009
histone methyltransferase activity (H3-R2 specific) 2.26179395735928 bayes_pls_golite062009
histone methyltransferase activity (H2A-R3 specific) 2.26179395735928 bayes_pls_golite062009
DNA-methyltransferase activity 2.18991764495147 bayes_pls_golite062009
[myelin basic protein]-arginine N-methyltransferase activity 2.10091845446893 bayes_pls_golite062009
transcription regulator activity 2.0187748912503 bayes_pls_golite062009
DNA binding 1.86585662505513 bayes_pls_golite062009
nucleic acid binding 1.71901340148111 bayes_pls_golite062009
catalytic activity 1.25333584501255 bayes_pls_golite062009
signal transducer activity 1.11388181877851 bayes_pls_golite062009
molecular transducer activity 1.11388181877851 bayes_pls_golite062009
binding 0.976078016260105 bayes_pls_golite062009
histone binding 0.964746527369069 bayes_pls_golite062009
protein-lysine N-methyltransferase activity 0.858129308056814 bayes_pls_golite062009
lysine N-methyltransferase activity 0.858129308056814 bayes_pls_golite062009
histone-lysine N-methyltransferase activity 0.858129308056814 bayes_pls_golite062009
RNA methyltransferase activity 0.817509452491588 bayes_pls_golite062009
site-specific DNA-methyltransferase (adenine-specific) activity 0.703178429468566 bayes_pls_golite062009
rRNA methyltransferase activity 0.230719796976667 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [166-259] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CSIHLAGLED SQYKDEKLNY WQDVYGFDYS PFVPLVLHEP IVDTVERNNV NTTSDKLIEF  60
   61 DLNTVKISDL AFKSNFKLTA KRQDMINGIV TWFD

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [274-348] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STGPHAPYTH WKQTIFYFPD DLDAETGDTI EGELVCSPNE KNNRDLNIKI SYKFESNGID  60
   61 GNSRSRKNEG SYLMH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10090.69897
Match: 1g6q1_
Description: Arginine methyltransferase, HMT1
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle