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View Structure Prediction Details

Protein: EDE1
Organism: Saccharomyces cerevisiae
Length: 1381 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EDE1.

Description E-value Query
Range		 Subject
Range
gi|68388302 - gi|68388302|ref|XP_696268.1| PREDICTED: similar to slow myosin heavy chain 1 [Danio rerio]
 650.0 [0..262] [1291..1869]
gi|50757613 - gi|50757613|ref|XP_415578.1| PREDICTED: similar to myosin heavy chain [Gallus gallus]
 528.0 [0..262] [1297..816]
MYH4_PIG - Myosin-4 OS=Sus scrofa GN=MYH4 PE=2 SV=1
 470.0 [0..262] [1298..867]
MYH4_MOUSE - Myosin-4 OS=Mus musculus GN=Myh4 PE=2 SV=1
 468.0 [0..262] [1298..869]
MYH4_CANLF - Myosin-4 OS=Canis lupus familiaris GN=MYH4 PE=3 SV=1
 467.0 [0..262] [1290..869]
MYH4_RAT - Myosin-4 OS=Rattus norvegicus GN=Myh4 PE=1 SV=1
 467.0 [0..262] [1298..869]

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Predicted Domain #1
Region A:
Residues: [1-115] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASITFRTPL SSQEQAFYNQ KFHQLDTEDL GVVTGEAVRP LFASSGLPGQ LLSQVWATVD  60
   61 IDNKGFLNLN EFSAALRMIA QLQNAPNQPI SAALYESTPT QLASFSINQN PAPMQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 83.124002
Match: 1qjtA
Description: Eps15
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [116-244] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGSATGNTNN TDIPALSSND IAKFSQLFDR TAKGAQTVAG DKAKDIFLKA RLPNQTLGEI  60
   61 WALCDRDASG VLDKSEFIMA MYLIQLCMSH HPSMNTPPAV LPTQLWDSIR LEPVVVNQPN 120
  121 RTTPLSANS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 161.39794
Match: 1eh2A
Description: STRUCTURE OF THE SECOND EPS15 HOMOLOGY DOMAIN OF HUMAN EPS15, NMR, 20 STRUCTURES
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [245-549] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TGVSSLTRHS TISRLSTGAF SNAASDWSLS FEKKQQFDAI FDSLDKQHAG SLSSAVLVPF  60
   61 FLSSRLNQET LATIWDLADI HNNAEFTKLE FAIAMFLIQK KNAGVELPDV IPNELLQSPA 120
  121 LGLYPPNPLP QQQSAPQIAI PSRASKPSLQ DMPHQVSAPA VNTQPTVPQV LPQNSNNGSL 180
  181 NDLLALNPSF SSPSPTKAQT VVQNNTNNSF SYDNNNGQAT LQQQQPQQPP PLTHSSSGLK 240
  241 KFTPTSNFGQ SIIKEEPEEQ EQLRESSDTF SAQPPPVPKH ASSPVKRTAS TTLPQVPNFS 300
  301 VFSMP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 66.07631
Match: 1i84S
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [550-590] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AGAATSAATG AAVGAAVGAA ALGASAFSRS SNNAFKNQDL F

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.67837
Match: 2tmaA
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [591-672] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ADGEASAQLS NATTEMANLS NQVNSLSKQA SITNDKKSRA TQELKRVTEM KNSIQIKLNN  60
   61 LRSTHDQNVK QTEQLEAQVL QV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.67837
Match: 2tmaA
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [673-734] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKENETLAQQ LAVSEANYHA AESKLNELTT DLQESQTKNA ELKEQITNLN SMTASLQSQL  60
   61 NE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.67837
Match: 2tmaA
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [735-823] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KQQQVKQERS MVDVNSKQLE LNQVTVANLQ KEIDGLGEKI SVYLTKQKEL NDYQKTVEEQ  60
   61 HAQLQAKYQD LSNKDTDLTD REKQLEERN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.67837
Match: 2tmaA
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #8
Region A:
Residues: [824-925] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RQIEEQENLY HQHVSKLQEM FDDLSQRKAS FEKADQELKE RNIEYANNVR ELSERQMNLA  60
   61 MGQLPEDAKD IIAKSASNTD TTTKEATSRG NVHEDTVSKF VE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score		 SCOP
Match		 SCOP Description
View Download 0.862 f.17.1 F1F0 ATP synthase subunit C
View Download 0.855 f.17.1 F1F0 ATP synthase subunit C
View Download 0.819 a.2.17 Description not found.
View Download 0.789 a.2.17 Description not found.
View Download 0.774 a.7.5 Tubulin chaperone cofactor A
View Download 0.774 a.7.5 Tubulin chaperone cofactor A
View Download 0.732 a.2.1 GreA transcript cleavage protein, N-terminal domain
View Download 0.717 a.2.17 Description not found.
View Download 0.689 a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.686 f.17.1 F1F0 ATP synthase subunit C

Predicted Domain #9
Region A:
Residues: [926-999] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TTVENSNLNV NRVKDDEEKT ERTESDVFDR DVPTLGSQSD SENANTNNGT QSGNETANPN  60
   61 LTETLSDRFD GDLN

[Run NCBI BLAST on this sequence.]

Detection Method: ab initio
Confidence: 10.67
Match:
Description: No description for 1l8mA was found.

Predicted Domain #10
Region A:
Residues: [1000-1078] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EYGIPRSQSL TSSVANNAPQ SVRDDVELPE TLEERDTINN TANRDNTGNL SHIPGEWEAT  60
   61 PATASTDVLS NETTEVIED

[Run NCBI BLAST on this sequence.]

Detection Method: ab initio
Confidence: 10.67
Match:
Description: No description for 1l8mA was found.

Predicted Domain #11
Region A:
Residues: [1079-1148] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSTTKRANSN EDGESVSSIQ ESPKISAQPK AKTINEEFPP IQELHIDESD SSSSDDDEFE  60
   61 DTREIPSATV

[Run NCBI BLAST on this sequence.]

Detection Method: ab initio
Confidence: 10.67
Match:
Description: No description for 1l8mA was found.

Predicted Domain #12
Region A:
Residues: [1149-1223] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KTLQTPYNAQ PTSSLEIHTE QVIKYPAPGT SPSHNEGNSK KASTNSILPV KDEFDDEFAG  60
   61 LEQAAVEEDN GADSE

[Run NCBI BLAST on this sequence.]

Detection Method: ab initio
Confidence: 10.67
Match:
Description: No description for 1l8mA was found.

Predicted Domain #13
Region A:
Residues: [1224-1335] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SEFENVANAG SMEQFETIDH KDLDDELQMN AFTGTLTSSS NPTIPKPQVQ QQSTSDPAQV  60
   61 SNDEWDEIFA GFGNSKAEPT KVATPSIPQQ PIPLKNDPIV DASLSKGPIV NR

[Run NCBI BLAST on this sequence.]

Detection Method: ab initio
Confidence: 14.51
Match:
Description: No description for 1ldvA was found.

Predicted Domain #14
Region A:
Residues: [1336-1381] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GVATTPKSLA VEELSGMGFT EEEAHNALEK CNWDLEAATN FLLDSA

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 5.920819
Match: PF00627
Description: UBA/TS-N domain

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle