YRC Public Data Repository - Protein Structure Prediction

Protein:	IMD1
Organism:	Saccharomyces cerevisiae
Length:	403 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for IMD1.

Description	E-value	Query Range	Subject Range
IMDH2_YEAST - Inosine-5'-monophosphate dehydrogenase 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN... IMD2 - Inosine monophosphate dehydrogenase, catalyzes the rate-limiting step in GTP biosynthesis, expressio...	0.0	[1..403]	[1..416]
gua1 - IMP dehydrogenase Gua1 IMDH_SCHPO - Inosine-5'-monophosphate dehydrogenase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=gua...	0.0	[1..403]	[1..418]
IMPDH1 - IMP (inosine 5'-monophosphate) dehydrogenase 1	0.0	[4..403]	[1..412]
IMDH_CANAL - Inosine-5'-monophosphate dehydrogenase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=IMH3 P... IMDH_CANAX - Inosine-5'-monophosphate dehydrogenase OS=Candida albicans GN=IMH3 PE=2 SV=1	0.0	[9..403]	[7..414]
IMDH2_MOUSE - Inosine-5'-monophosphate dehydrogenase 2 OS=Mus musculus GN=Impdh2 PE=1 SV=2	0.0	[4..403]	[1..412]
IMDH_BACSU - Inosine-5'-monophosphate dehydrogenase OS=Bacillus subtilis (strain 168) GN=guaB PE=1 SV=2 gi\|221312140 - gi\|221312140\|ref\|ZP_03593945.1\| inositol-5'-monophosphate dehydrogenase [Bacillus subtilis subsp. su... gi\|221317073 - gi\|221317073\|ref\|ZP_03598367.1\| inositol-5'-monophosphate dehydrogenase [Bacillus subtilis subsp. su... IMDH_BACSU - Inosine-5'-monophosphate dehydrogenase OS=Bacillus subtilis GN=guaB PE=1 SV=2 gi\|221321336 - gi\|221321336\|ref\|ZP_03602630.1\| inositol-5'-monophosphate dehydrogenase [Bacillus subtilis subsp. su...	0.0	[29..403]	[3..389]
IMDH2_CRIGR - Inosine-5'-monophosphate dehydrogenase 2 OS=Cricetulus griseus GN=IMPDH2 PE=1 SV=1	0.0	[4..403]	[1..412]

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Predicted Domain #1

Region A:
Residues: [1-403]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAIRDYKTA LDLTKSLPRP DGLSVQELMD SKIRGGLAYN DFLILPGLVD FASSEVSLQT  60
   61 KLTRNITLNI PLVSSPMDTV TESEMATFMA LLDGIGFIHH NCTPEDQADM VRRVKNYENG 120
  121 FINNPIVISP TTTVGEAKSM KEKYGFAGFP VTADGKRNAK LVGAITSRDI QFVEDNSLLV 180
  181 QDVMTKNPVT GAQGITLSEG NEILKKIKKG RLLVVDEKGN LVSMLSRTDL MKNQKYPLAS 240
  241 KSANTKQLLW GASIGTMDAD KERLRLLVKA GLDVVILDSS QGNSIFQLNM IKWIKETFPD 300
  301 LEIIAGNVVT KEQAANLIAA GADGLRIGMG TGSICITQKV MACGRPQGTA VYNVCEFANQ 360
  361 FGVPCMADGG VQKHWSYYYQ SFGSWFFYCY DGWYVGRYYR ITR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1285.0
Match:	1b3oA_
Description:	Inosine monophosphate dehydrogenase (IMPDH)
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits