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View Structure Prediction Details

Protein: PRP45
Organism: Saccharomyces cerevisiae
Length: 379 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PRP45.

Description E-value Query
Range
Subject
Range
gi|207348024 - gi|207348024|gb|EDZ74005.1| YAL032Cp-like protein [Saccharomyces cerevisiae AWRI1631]
PRP45 - Protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing ...
PRP45_YEAST - Pre-mRNA-processing protein 45 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PRP45 PE=...
0.0 [1..379] [1..379]
gi|61357157, gi|... - gi|61357163|gb|AAX41344.1| SKI interacting protein [synthetic construct], gi|61357157|gb|AAX41343.1|...
SNW1 - SNW domain containing 1
gi|114654181 - gi|114654181|ref|XP_510097.2| PREDICTED: SKI-interacting protein isoform 3 [Pan troglodytes]
0.0 [3..368] [83..497]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [1..312] [1..312]
Bx42-PA, FBpp0305943 - The gene Bx42 is referred to in FlyBase by the symbol Dmel\Bx42 (CG8264, FBgn0004856). It is a prote...
gi|220954608, gi... - gi|220954608|gb|ACL89847.1| Bx42-PA [synthetic construct], gi|220944828|gb|ACL84957.1| CG8264-PA [sy...
0.0 [3..369] [86..509]
SKIP_ARATH - SNW/SKI-interacting protein OS=Arabidopsis thaliana GN=SKIP PE=1 SV=1
0.0 [5..372] [93..555]
prp45 - transcriptional regulator Prp45
PRP45_SCHPO - Pre-mRNA-processing protein 45 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=prp45 PE=1 ...
0.0 [4..371] [89..541]
gi|85101656 - gi|85101656|ref|XP_961188.1| pre-mRNA splicing factor prp45 [Neurospora crassa OR74A]
gi|32404974, gi|... - gi|32404974|ref|XP_323100.1| hypothetical protein ( (AL451018) probable puff-specific nuclear protei...
2.0E-99 [3..372] [92..526]
gi|12843873 - gi|12843873|dbj|BAB26144.1| unnamed protein product [Mus musculus]
5.0E-78 [119..368] [1..294]
gi|60474007, gi|... - gi|66825409|ref|XP_646059.1| nuclear receptor coactivator NC0A-62 [Dictyostelium discoideum AX4], gi...
SNWA_DICDI - Protein snwA OS=Dictyostelium discoideum GN=snwA PE=1 SV=1
3.0E-70 [7..255] [113..358]

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Predicted Domain #1
Region A:
Residues: [1-57]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFSNRLPPPK HSQGRVSTAL SSDRVEPAIL TDQIAKNVKL DDFIPKRQSN FELSVPL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.427 0.542 transcription activator activity a.4.1 Homeodomain-like
View Download 0.419 0.275 transcription activator activity a.4.5 "Winged helix" DNA-binding domain
View Download 0.469 0.028 positive regulation of transcription from RNA polymerase II promoter a.77.1 DEATH domain
View Download 0.322 0.001 positive regulation of transcription from RNA polymerase II promoter a.144.2 Ribosomal protein L20
View Download 0.469 N/A N/A a.77.1 DEATH domain
View Download 0.427 N/A N/A a.4.1 Homeodomain-like
View Download 0.419 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.377 N/A N/A a.4.1 Homeodomain-like
View Download 0.328 N/A N/A a.144.2 Ribosomal protein L20
View Download 0.295 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.273 N/A N/A a.5.2 UBA-like
View Download 0.271 N/A N/A a.60.2 RuvA domain 2-like
View Download 0.268 N/A N/A d.7.1 LysM domain
View Download 0.252 N/A N/A a.4.1 Homeodomain-like
View Download 0.244 N/A N/A a.4.2 Methylated DNA-protein cysteine methyltransferase, C-terminal domain
View Download 0.238 N/A N/A d.58.38 Urease metallochaperone UreE, C-terminal domain
View Download 0.222 N/A N/A a.60.1 SAM/Pointed domain
View Download 0.202 N/A N/A a.4.1 Homeodomain-like

Predicted Domain #2
Region A:
Residues: [58-312]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PTKAEIQECT ARTKSYIQRL VNAKLANSNN RASSRYVTET HQAPANLLLN NSHHIEVVSK  60
   61 QMDPLLPRFV GKKARKVVAP TENDEVVPVL HMDGSNDRGE ADPNEWKIPA AVSNWKNPNG 120
  121 YTVALERRVG KALDNENNTI NDGFMKLSEA LENADKKARQ EIRSKMELKR LAMEQEMLAK 180
  181 ESKLKELSQR ARYHNGTPQT GAIVKPKKQT STVARLKELA YSQGRDVSEK IILGAAKRSE 240
  241 QPDLQYDSRF FTRGA

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 109.853872
Match: PF02731
Description: SKIP/SNW domain

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [313-379]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NASAKRHEDQ VYDNPLFVQQ DIESIYKTNY EKLDEAVNVK SEGASGSHGP IQFTKAESDD  60
   61 KSDNYGA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.562 a.4.1 Homeodomain-like
View Download 0.492 a.3.1 Cytochrome c
View Download 0.473 a.60.3 C-terminal domain of RNA polymerase alpha subunit
View Download 0.455 a.37.1 A DNA-binding domain in eukaryotic transcription factors
View Download 0.440 a.4.1 Homeodomain-like
View Download 0.410 a.60.1 SAM/Pointed domain
View Download 0.406 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.396 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.384 a.65.1 Annexin
View Download 0.382 a.83.1 Guanido kinase N-terminal domain
View Download 0.382 a.4.5 "Winged helix" DNA-binding domain
View Download 0.368 a.60.11 Hypothetical protein YjbJ
View Download 0.363 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.358 a.4.11 RNA polymerase subunit RPB10
View Download 0.341 a.64.2 Bacteriocin AS-48
View Download 0.340 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.329 a.4.1 Homeodomain-like
View Download 0.322 a.36.1 Signal peptide-binding domain
View Download 0.317 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.317 a.164.1 C-terminal domain of DFF45/ICAD (DFF-C domain)
View Download 0.291 a.112.1 Description not found.
View Download 0.290 a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.288 a.60.5 Barrier-to-autointegration factor, BAF
View Download 0.280 a.108.1 Ribosomal protein L7/12, oligomerisation (N-terminal) domain
View Download 0.274 a.77.1 DEATH domain
View Download 0.272 f.14.1 Voltage-gated potassium channels
View Download 0.240 a.3.1 Cytochrome c
View Download 0.237 a.3.1 Cytochrome c
View Download 0.231 a.77.1 DEATH domain
View Download 0.212 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.208 a.76.1 Iron-dependent represor protein, dimerization domain

Predicted functions:

Term Confidence Notes
binding 2.59005615358803 bayes_pls_golite062009
protein binding 2.41769888237582 bayes_pls_golite062009
tubulin binding 0.684160753873506 bayes_pls_golite062009
cytoskeletal protein binding 0.538779930266561 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [298-379]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QPDLQYDSRF FTRGANASAK RHEDQVYDNP LFVQQDIESI YKTNYEKLDE AVNVKSEGAS  60
   61 GSHGPIQFTK AESDDKSDNY GA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.562 N/A N/A a.4.1 Homeodomain-like
View Download 0.492 N/A N/A a.3.1 Cytochrome c
View Download 0.476 N/A N/A a.4.1 Homeodomain-like
View Download 0.473 N/A N/A a.60.3 C-terminal domain of RNA polymerase alpha subunit
View Download 0.455 N/A N/A a.37.1 A DNA-binding domain in eukaryotic transcription factors


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle