YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|122889278, gi...
Organism:	Homo sapiens
Length:	687 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|122889278, gi....

Description	E-value	Query Range	Subject Range
gi\|109496527 - gi\|109496527\|ref\|XP_001068449.1\| PREDICTED: similar to PABP-dependent poly(A) nuclease 3 [Rattus nor...	8.0E-63	[1..685]	[143..827]
gi\|83286005 - gi\|83286005\|ref\|XP_729972.1\| hypothetical protein [Plasmodium yoelii yoelii str. 17XNL] gi\|23489282 - gi\|23489282\|gb\|EAA21537.1\| Plasmodium falciparum CDPK2 protein [Plasmodium yoelii yoelii]	9.0E-63	[298..687]	[124..510]
gi\|114649216 - gi\|114649216\|ref\|XP_001136697.1\| PREDICTED: PABP1-dependent poly A-specific ribonuclease subunit PAN...	1.0E-62	[1..687]	[1..687]
gi\|109120285 - gi\|109120285\|ref\|XP_001097417.1\| PREDICTED: similar to PABP1-dependent poly A-specific ribonuclease ...	1.0E-62	[1..687]	[1..687]
gi\|38453755 - gi\|38453755\|dbj\|BAD02262.1\| PABP1-DEPENDENT POLY(A)-SPECIFIC RIBONUCLEASE SUBUNIT PAN3 [Homo sapiens...	6.0E-62	[1..687]	[1..687]
PAN3_MOUSE - PAB-dependent poly(A)-specific ribonuclease subunit 3 OS=Mus musculus GN=Pan3 PE=2 SV=2	5.0E-61	[1..685]	[1..685]
gi\|71033905 - gi\|71033905\|ref\|XP_766594.1\| calmodulin-domain protein kinase [Theileria parva strain Muguga] gi\|68353551 - gi\|68353551\|gb\|EAN34311.1\| calmodulin-domain protein kinase, putative [Theileria parva]	8.0E-61	[288..687]	[46..456]
gi\|118378182 - gi\|118378182\|ref\|XP_001022267.1\| Protein kinase domain containing protein [Tetrahymena thermophila] gi\|118378182, gi... - gi\|89304034\|gb\|EAS02022.1\| Protein kinase domain containing protein [Tetrahymena thermophila SB210],...	1.0E-60	[263..685]	[22..444]
Akt1-PC - The gene Akt1 is referred to in FlyBase by the symbol Dmel\Akt1 (CG4006, FBgn0010379). It is a prote...	1.0E-60	[39..584]	[11..553]

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Predicted Domain #1

Region A:
Residues: [1-566]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDGGALTDTS LTDSYFSTSF IGVNGFGSPV ETKYPLMQRM TNSSSSPSLL NDSAKPYSAH  60
   61 DPLTSPASSL FNDFGALNIS QRRKTPNPTA SEFIPKGGST SRLSNVSQSN MSAFSQVFSH 120
  121 PSMGSPATAG LAPGMSLSAG SSPLHSPKIT PHTSPAPRRR SHTPNPASYM VPSSASTSVN 180
  181 NPVSQTPSSG QVIQKETVGG TTYFYTDTTP APLTGMVFPN YHIYPPTAPH VAYMQPKANA 240
  241 PSFFMADELR QELINRHLIT MAQIDQADMP AVPTEVDSYH SLFPLEPLPP PNRIQKSSNF 300
  301 GYITSCYKAV NSKDDLPYCL RRIHGFRLVN TKCMVLVDMW KKIQHSNIVT LREVFTTKAF 360
  361 AEPSLVFAYD FHAGGETMMS RHFNDPNADA YFTKRKWGQH EGPLPRQHAG LLPESLIWAY 420
  421 IVQLSSALRT IHTAGLACRV MDPTKILITG KTRLRVNCVG VFDVLTFDNS QNNNPLALMA 480
  481 QYQQADLISL GKVVLALACN SLAGIQRENL QKAMELVTIN YSSDLKNLIL YLLTDQNRMR 540
  541 SVNDIMPMIG ARFYTQLDAA QMRNDV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	52.30103
Match:	2h8hA
Description:	No description for 2h8hA was found.

Predicted functions:

Term	Confidence	Notes
protein kinase activity	0.992326239767221	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.952736015121484	bayes_pls_golite062009
kinase activity	0.887449738641687	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.826422905101088	bayes_pls_golite062009
transferase activity	0.592356370285824	bayes_pls_golite062009
binding	0.468768937960882	bayes_pls_golite062009
catalytic activity	0.450122697269263	bayes_pls_golite062009
protein serine/threonine kinase activity	0.372809552991468	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [567-687]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IEEDLAKEVQ NGRLFRLLAK LGTINERPEF QKDPTWSETG DRYLLKLFRD HLFHQVTEAG  60
   61 APWIDLSHII SCLNKLDAGV PEKISLISRD EKSVLVVTYS DLKRCFENTF QELIAAANGQ 120
  121 L

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	42.0
Match:	1omwA
Description:	G-protein coupled receptor kinase 2, N-terminal domain; G-protein coupled receptor kinase 2 (beta-adrenergic receptor kinase 1); G-protein coupled receptor kinase 2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein kinase activity	0.992326239767221	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.952736015121484	bayes_pls_golite062009
kinase activity	0.887449738641687	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.826422905101088	bayes_pls_golite062009
transferase activity	0.592356370285824	bayes_pls_golite062009
binding	0.468768937960882	bayes_pls_golite062009
catalytic activity	0.450122697269263	bayes_pls_golite062009
protein serine/threonine kinase activity	0.372809552991468	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: