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View Structure Prediction Details

Protein: gi|62484308, gi|...
Organism: Drosophila melanogaster
Length: 816 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|62484308, gi|....

Description E-value Query
Range
Subject
Range
gi|62484485, gi|... - gi|62484485|ref|NP_732499.2| CG5077-PB, isoform B [Drosophila melanogaster], gi|61679364|gb|AAN13825...
749.0 [0..1] [816..1]

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Predicted Domain #1
Region A:
Residues: [1-202]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNLLQRIANW ASDNRDGNVA DKATADAAKL NRKESYKAQR KNYRREKKRV ASELMNSLQD  60
   61 PAVIVLADWL KVRGTLKSWT KLWCVLKPGL LLIYKSQKTK SSHWVGTVML TSCQVIERPS 120
  121 KKDGFCFKLF HPLEQSIWAP RGPDKETIGA VVQPLPTAYL IFRAPSQAAG KCWMDALELS 180
  181 LRCSALLLRS NSSTGTAPTS SY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.522879
Match: 1v88A
Description: Solution Structure of the Pleckstrin Homology Domain of Oxysterol-Binding Protein-Related Protein 8 (KIAA1451 Protein)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.71153495886736 bayes_pls_golite062009
protein binding 1.18328783605179 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [203-272]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IGEPLPVSHE TQWSEADYEK HFNDHDLDAD SQNEAPNAVM SGLESESESD PAEPAQDDVV  60
   61 DQQCVETSYV 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [273-644]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PFTEEEFGEQ GEQVEELAEE NKSLIWCIVK QVRPGMDLSK VVLPTFILEP RSFLDKLSDS  60
   61 YYHADLLSKA VQEDDAFTRM KLVVQWYLSS FYKKPKGLKK PYNPILGERF RCYWQHPSGS 120
  121 RTFYIAEQVS HHPPVSAFYV TNREDGFSIT CSILAKSKFY GNSTSAVLEG AATMTLLPRG 180
  181 ECYTATTPYA HCKGILMGTL SMELGGKINI ECENTGYRTE LEFKLKPFLG GADATNVVVG 240
  241 KIKLGKETLA TINGHWDKEC RVKDSKTGEE TVLFKVDAET RSKRLTRYMV PLDLQEANES 300
  301 QRLWQRVSEA IANEDQVAAT EEKTVLEERQ RADAKERLSS DSVHMPDLFE LDSYGQWLYK 360
  361 YADLRPWDSR ND

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 74.0
Match: 1zhtA
Description: Structure of yeast oxysterol binding protein Osh4 in complex with 7-hydroxycholesterol
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
sterol binding 3.12877992228795 bayes_pls_golite062009
steroid binding 2.54679035876403 bayes_pls_golite062009
lipid binding 1.46539100663772 bayes_pls_golite062009
oxysterol binding 1.1738554488982 bayes_pls_golite062009
binding 0.958372296392311 bayes_pls_golite062009
0.35288515581255 bayes_pls_golite062009
phospholipid binding 0.0867097353003303 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [645-816]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VRQYECQFKV LTQTRHKSVP IVHGAEMIHP LRSSIETLSR TQRQSPAGQP LPPGGSAVPK  60
   61 AKNKSLVLAP RDTNSDSSQS PQGAVKRSSS SAIKQLALAV DQVNRVLEQH TRQLNEISQR 120
  121 LERMQYSPPP SSMSAHSLHM LGGGVSQSTV IKSLIYALIG LAFSLILRWL FK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle