YRC Public Data Repository - Protein Structure Prediction

Protein:	ISU1_SCHPO
Organism:	Schizosaccharomyces pombe 972h-
Length:	192 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ISU1_SCHPO.

Description	E-value	Query Range	Subject Range
ISU3_ARATH - Iron-sulfur cluster assembly protein 3 OS=Arabidopsis thaliana GN=ISU3 PE=2 SV=1	212.0	[0..32]	[190..1]
gi\|76573610 - gi\|76573610\|dbj\|BAE44694.1\| hypothetical protein [Candida albicans] gi\|68469194, gi\|... - gi\|77022706\|ref\|XP_888797.1\| hypothetical protein CaO19_6548 [Candida albicans SC5314], gi\|68470219\|...	212.0	[0..22]	[181..2]
gi\|117645092, gi... - gi\|157929172\|gb\|ABW03871.1\| iron-sulfur cluster scaffold homolog (E. coli) [synthetic construct], gi... ISCU - iron-sulfur cluster scaffold homolog (E. coli)	210.0	[0..17]	[184..1]
gi\|20381021 - gi\|20381021\|gb\|AAH28800.1\| Iscu protein [Mus musculus]	210.0	[0..18]	[182..1]
gi\|46100695, gi\|... - gi\|71023099\|ref\|XP_761779.1\| hypothetical protein UM05632.1 [Ustilago maydis 521], ref\|XP_403247.1\| ...	208.0	[0..9]	[191..12]
gi\|58387816, gi\|... - gi\|58387816\|ref\|XP_315834.2\| AGAP005813-PA [Anopheles gambiae str. PEST], gi\|55238630\|gb\|EAA10764.2\|... AGAP005813-PA - FeS cluster assembly scaffold IscU\|protein_coding\|2L:21632740:21633195:1\|gene:AGAP005813	208.0	[0..25]	[178..1]
gi\|109098615 - gi\|109098615\|ref\|XP_001103180.1\| PREDICTED: similar to iron-sulfur cluster assembly enzyme isoform I... gi\|149720512 - gi\|149720512\|ref\|XP_001501092.1\| PREDICTED: similar to ISCU2 [Equus caballus] gi\|114646776 - gi\|114646776\|ref\|XP_509343.2\| PREDICTED: similar to ISCU2 isoform 2 [Pan troglodytes] ENSCJAT00000029974 - null	208.0	[0..17]	[184..1]
gi\|109497403, gi... - gi\|27666566\|ref\|XP_213811.1\| PREDICTED: similar to nitrogen fixation cluster-like [Rattus norvegicus...	208.0	[0..17]	[182..1]
gi\|54261801, gi\|... - gi\|54261801\|ref\|NP_001003632.1\| iron-sulfur cluster assembly enzyme [Danio rerio], gi\|50418507\|gb\|AA...	208.0	[0..34]	[186..9]

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Predicted Domain #1

Region A:
Residues: [1-192]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVFRRSVQC VGVLPSILAQ RSSLLARPAN LQFLKTNSSK FVPQVTANVS RRMYHKNVLD  60
   61 HYNNPRNVGT LPKGDPDVGI GLVGAPACGD VMRLAIRVNK DGVIEDVKFK TFGCGSAIAS 120
  121 SSYVTTMVKG MTLEEASKIK NTQIAKELCL PPVKLHCSML AEDAIKSAVK HYRSKQLTPV 180
  181 GTTAGAIESA TA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	51.522879
Match:	1q48A
Description:	Solution NMR Structure of The Haemophilus Influenzae Iron-Sulfur Cluster Assembly Protein U (IscU) with Zinc Bound at the Active Site. Northeast Structural Genomics Consortium Target IR24. This protein is not apo, it is a model without zinc binding constr
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	1.25897597318598	bayes_pls_golite062009
iron ion binding	0.905595388647019	bayes_pls_golite062009
protein binding	0.257846679116775	bayes_pls_golite062009
catalytic activity	0.256292883613773	bayes_pls_golite062009
transition metal ion binding	0.192770514366253	bayes_pls_golite062009
2 iron, 2 sulfur cluster binding	0.0439466134407704	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: