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View Structure Prediction Details

Protein: TFB4_SCHPO
Organism: Schizosaccharomyces pombe 972h-
Length: 297 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TFB4_SCHPO.

Description E-value Query
Range
Subject
Range
gi|2257568 - gi|2257568|dbj|BAA21460.1| basic transcription factor 2.35KD subunit [Schizosaccharomyces pombe]
364.0 [0..1] [292..1]
gi|1039318 - gi|1039318|emb|CAA82909.1| basic transcription factor 2, 35 kD subunit [Homo sapiens]
325.0 [0..20] [290..5]
gi|114647703 - gi|114647703|ref|XP_001170519.1| PREDICTED: general transcription factor IIH, polypeptide 3, 34kDa i...
323.0 [0..20] [290..5]
gi|57105536 - gi|57105536|ref|XP_534644.1| PREDICTED: similar to general transcription factor IIH, polypeptide 3, ...
323.0 [0..20] [290..5]
TF2H3_RAT - General transcription factor IIH subunit 3 OS=Rattus norvegicus GN=Gtf2h3 PE=2 SV=1
322.0 [0..20] [290..5]
TF2H3_MOUSE - General transcription factor IIH subunit 3 OS=Mus musculus GN=Gtf2h3 PE=1 SV=1
319.0 [0..20] [290..5]

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Predicted Domain #1
Region A:
Residues: [1-297]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDEFQTLKQN ASWDISEDAN DTPSLLVVIL DANPASWYSL SKKVPVSKVL ADITVFLNAH  60
   61 LAFHHDNRVA VLASHSDKVE YLYPSIAPEQ KVAEVDPTKE ANTYRKFREV DDLVLSGMKR 120
  121 LMSSTDKVSR KTMISGALSR ALAYINQVQN KNTLRSRILI FSLTGDVALQ YIPTMNCIFC 180
  181 AQKKNIPINV CNIEGGTLFL EQAADATGGI YLKVDNPKGL LQYLMMSLFP DQNLRKHLNT 240
  241 PNQANVDFRA TCFCHKKVLD IGFVCSVCLS IFCEPRVHCS TCHTKFTVEP MSKKLHT

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.38
Match: 1q0pA
Description: A domain of Factor B
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.68315152218267 bayes_pls_golite062009
nucleic acid binding 2.10023916482665 bayes_pls_golite062009
DNA binding 1.9295508897092 bayes_pls_golite062009
protein complex binding 1.65763332955233 bayes_pls_golite062009
protein binding 1.42792331963866 bayes_pls_golite062009
hydrolase activity 0.589248272940562 bayes_pls_golite062009
structure-specific DNA binding 0.446181458443121 bayes_pls_golite062009
protein dimerization activity 0.244402438311177 bayes_pls_golite062009
protein heterodimerization activity 0.114607758890868 bayes_pls_golite062009
catalytic activity 0.0380261580236634 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle