YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|254235597, gi...
Organism:	Pseudomonas aeruginosa C3719
Length:	465 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|254235597, gi....

Description	E-value	Query Range	Subject Range
CYSG_NITEC - Siroheme synthase OS=Nitrosomonas eutropha (strain C91) GN=cysG PE=3 SV=1	0.0	[1..460]	[1..461]
gi\|30248547, gi\|... - gi\|30248547\|ref\|NP_840617.1\| cysG_2; uroporphyrinogen-III methylase [Nitrosomonas europaea ATCC 1971...	0.0	[1..460]	[27..487]
gi\|196158491, gi... - gi\|88794338\|ref\|ZP_01110047.1\| uroporphyrin-III C-methyltransferase [Alteromonas macleodii 'Deep eco...	0.0	[1..458]	[19..477]
gi\|89083226, gi\|... - gi\|89092714\|ref\|ZP_01165667.1\| siroheme synthase [Oceanospirillum sp. MED92], gi\|89083226\|gb\|EAR6244...	0.0	[1..458]	[1..458]
CYSG_PSEHT - Siroheme synthase OS=Pseudoalteromonas haloplanktis (strain TAC 125) GN=cysG PE=3 SV=1	0.0	[1..463]	[1..461]
gi\|77962694, gi\|... - gi\|77962694\|ref\|ZP_00826511.1\| COG0007: Uroporphyrinogen-III methylase [Yersinia mollaretii ATCC 439...	0.0	[1..463]	[1..459]
CYSG2_YERPS - Siroheme synthase 2 OS=Yersinia pseudotuberculosis GN=cysG2 PE=3 SV=1 CYSG2_YERPS - Siroheme synthase 2 OS=Yersinia pseudotuberculosis serotype I (strain IP32953) GN=cysG2 PE=3 SV=1 gi\|170022493, gi... - gi\|170022493\|ref\|YP_001718998.1\| siroheme synthase [Yersinia pseudotuberculosis YPIII], gi\|169749027... CYSG2_YERP3 - Siroheme synthase 2 OS=Yersinia pseudotuberculosis serotype O:1b (strain IP 31758) GN=cysG2 PE=3 SV=...	0.0	[1..464]	[1..460]
gi\|126194422, gi... - gi\|84326938\|ref\|ZP_00974962.1\| COG0007: Uroporphyrinogen-III methylase [Pseudomonas aeruginosa 2192]...	0.0	[1..465]	[1..465]
gi\|82703430, gi\|... - gi\|82703430\|ref\|YP_412996.1\| uroporphyrin-III C-methyltransferase [Nitrosospira multiformis ATCC 251...	0.0	[2..462]	[32..496]
CYSG_PSEAB - Siroheme synthase OS=Pseudomonas aeruginosa (strain UCBPP-PA14) GN=cysG PE=3 SV=1	0.0	[1..465]	[1..465]

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Predicted Domain #1

Region A:
Residues: [1-465]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDFLPLFHSL QGRLALVVGG GEVALRKARL LADAGARLRV VAPQIHIELR HLVEQGGGEL  60
   61 LERDYQDGDQ PGCALIIAAT DDEPLNAEVS RAANARGIPV NVVDAPALCS VIFPAIVDRS 120
  121 PLVVAVSSGG DAPVLARLIR AKLETWIPST YGQLAGLASR FRHRVKELLP DLQQRRVFWE 180
  181 NLFQGEIAER VLAGRPAEAE RLLEEHLAGG LAHIATGEVY LVGAGPGDPD LLTFRALRLM 240
  241 QQADVVLYDR LVAPSILELC RRDAERLYVG KRRAEHAVPQ DRINRLLVEL ASQGKRVLRL 300
  301 KGGDPFIFGR GGEEIDELAA HGIPFQVVPG ITAASGCAAY AGIPLTHRDH AQSVRFVTGH 360
  361 LKDGTTDLPW QDLVAPGQTL VFYMGLVGLP VICEQLVAHG RSAQTPAALI QQGTTAQQRV 420
  421 FTGTLENLPQ LVAEHEVHAP TLVIVGEVVQ LRDKLAWFEG AREDA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	126.0
Match:	1pjqA
Description:	Structure and function of CysG, the multifunctional methyltransferase/dehydrogenase/ferrochelatase for siroheme synthesis
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
uroporphyrin-III C-methyltransferase activity	3.573271502205	bayes_pls_golite062009
C-methyltransferase activity	3.35393353163232	bayes_pls_golite062009
precorrin-4 C11-methyltransferase activity	2.18371138649366	bayes_pls_golite062009
catalytic activity	1.48349578618275	bayes_pls_golite062009
transferase activity	0.912524944496351	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	0.431791521097299	bayes_pls_golite062009
methyltransferase activity	0.424918406685891	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	0.28351517300952	bayes_pls_golite062009
uroporphyrinogen-III synthase activity	0.00871858903098705	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: