YRC Public Data Repository - Protein Structure Prediction

Protein:	LPXH_SHIBS
Organism:	Shigella boydii Sb227
Length:	240 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LPXH_SHIBS.

Description	E-value	Query Range	Subject Range
LPXH_VIBVY - UDP-2,3-diacylglucosamine hydrolase OS=Vibrio vulnificus (strain YJ016) GN=lpxH PE=3 SV=1	255.0	[0..1]	[240..1]
LPXH_SHISS - UDP-2,3-diacylglucosamine hydrolase OS=Shigella sonnei (strain Ss046) GN=lpxH PE=3 SV=1	255.0	[0..1]	[240..1]
LPXH_VIBVU - UDP-2,3-diacylglucosamine hydrolase OS=Vibrio vulnificus GN=lpxH PE=3 SV=2 LPXH_VIBVU - UDP-2,3-diacylglucosamine hydrolase OS=Vibrio vulnificus (strain CMCP6) GN=lpxH PE=3 SV=2	254.0	[0..1]	[240..1]
gi\|194418966, gi... - gi\|83570234\|ref\|ZP_00921680.1\| COG2908: Uncharacterized protein conserved in bacteria [Shigella dyse...	254.0	[0..1]	[240..1]
gi\|188487603, gi... - gi\|75514642\|ref\|ZP_00736897.1\| COG2908: Uncharacterized protein conserved in bacteria [Escherichia c... LPXH_ECOSE - UDP-2,3-diacylglucosamine hydrolase OS=Escherichia coli (strain SE11) GN=lpxH PE=3 SV=1 LPXH_ECOSM - UDP-2,3-diacylglucosamine hydrolase OS=Escherichia coli (strain SMS-3-5 / SECEC) GN=lpxH PE=3 SV=1	253.0	[0..1]	[240..1]
gi\|89075762, gi\|... - gi\|89075762\|ref\|ZP_01162150.1\| UDP-2,3-diacylglucosamine hydrolase [Photobacterium sp. SKA34], gi\|89...	253.0	[0..1]	[240..1]
LPXH_SHIDS - UDP-2,3-diacylglucosamine hydrolase OS=Shigella dysenteriae serotype 1 (strain Sd197) GN=lpxH PE=3 S...	253.0	[0..1]	[240..1]
gi\|75257836, gi\|... - gi\|75257836\|ref\|ZP_00729314.1\| COG2908: Uncharacterized protein conserved in bacteria [Escherichia c... gi\|194412386, gi... - gi\|75209172\|ref\|ZP_00709423.1\| COG2908: Uncharacterized protein conserved in bacteria [Escherichia c...	253.0	[0..1]	[240..1]
gi\|15829840, gi\|... - gi\|15829840\|ref\|NP_308613.1\| UDP-2,3-diacylglucosamine hydrolase [Escherichia coli O157:H7 str. Saka... gi\|217322624, gi... - gi\|217326403\|ref\|ZP_03442487.1\| UDP-2,3-diacylglucosamine hydrolase [Escherichia coli O157:H7 str. T... gi\|195936091 - gi\|195936091\|ref\|ZP_03081473.1\| UDP-2,3-diacylglucosamine hydrolase [Escherichia coli O157:H7 str. E... gi\|168798098, gi... - gi\|189379238\|gb\|EDU97654.1\| UDP-2,3-diacylglucosamine hydrolase [Escherichia coli O157:H7 str. EC508... gi\|189373627, gi... - gi\|189373627\|gb\|EDU92043.1\| UDP-2,3-diacylglucosamine hydrolase [Escherichia coli O157:H7 str. EC869... gi\|189002801, gi... - gi\|189002801\|gb\|EDU71787.1\| UDP-2,3-diacylglucosamine hydrolase [Escherichia coli O157:H7 str. EC407... LPXH_ECO5E - UDP-2,3-diacylglucosamine hydrolase OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=lpxH PE=3 ... gi\|208737014, gi... - gi\|208822821\|ref\|ZP_03263139.1\| UDP-2,3-diacylglucosamine hydrolase [Escherichia coli O157:H7 str. E... gi\|208732462, gi... - gi\|208815814\|ref\|ZP_03256993.1\| UDP-2,3-diacylglucosamine hydrolase [Escherichia coli O157:H7 str. E... gi\|208729254, gi... - gi\|208809453\|ref\|ZP_03251790.1\| UDP-2,3-diacylglucosamine hydrolase [Escherichia coli O157:H7 str. E... gi\|188017692, gi... - gi\|188017692\|gb\|EDU55814.1\| UDP-2,3-diacylglucosamine hydrolase [Escherichia coli O157:H7 str. EC411... gi\|254591112, gi... - gi\|254791712\|ref\|YP_003076549.1\| UDP-2,3-diacylglucosamine pyrophosphatase [Escherichia coli O157:H7... gi\|209777906, gi... - pir\|\|E85552 hypothetical protein ybbF [imported] - Escherichia coli (strain O157:H7, substrain EDL9... gi\|168774600, gi... - gi\|187769794\|gb\|EDU33638.1\| UDP-2,3-diacylglucosamine hydrolase [Escherichia coli O157:H7 str. EC419... gi\|12513421, gi\|... - gi\|15800261\|ref\|NP_286273.1\| UDP-2,3-diacylglucosamine hydrolase [Escherichia coli O157:H7 EDL933], ... gi\|189362459, gi... - gi\|189362459\|gb\|EDU80878.1\| UDP-2,3-diacylglucosamine hydrolase [Escherichia coli O157:H7 str. EC448... gi\|168760312, gi... - gi\|189369052\|gb\|EDU87468.1\| UDP-2,3-diacylglucosamine hydrolase [Escherichia coli O157:H7 str. EC450... gi\|168754638, gi... - gi\|189358039\|gb\|EDU76458.1\| UDP-2,3-diacylglucosamine hydrolase [Escherichia coli O157:H7 str. EC440... LPXH_ECO57 - UDP-2,3-diacylglucosamine hydrolase OS=Escherichia coli O157:H7 GN=lpxH PE=3 SV=1	253.0	[0..1]	[240..1]
LPXH_ECOLC - UDP-2,3-diacylglucosamine hydrolase OS=Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks) GN=lp... EG12666 - UDP-2,3-diacylglucosamine pyrophosphohydrolase / Lipid A synthesis, UDP-2,3-diacylglucosamine pyroph... gi\|124499935, gi... - gi\|124529335\|ref\|ZP_01700369.1\| UDP-2,3-diacylglucosamine hydrolase [Escherichia coli B], gi\|1244999... LPXH_ECOLI - UDP-2,3-diacylglucosamine hydrolase (EC 3.6.1.-) - Escherichia coli LPXH_ECODH - UDP-2,3-diacylglucosamine hydrolase OS=Escherichia coli (strain K12 / DH10B) GN=lpxH PE=3 SV=1 gi\|89107391, gi\|... - gi\|89107391\|ref\|AP_001171.1\| UDP-2,3-diacylglucosamine pyrophosphatase [Escherichia coli str. K-12 s... LPXH_ECOBW - UDP-2,3-diacylglucosamine hydrolase OS=Escherichia coli (strain K12 / MC4100 / BW2952) GN=lpxH PE=3 ... EG12666 - UDP-2,3-diacylglucosamine pyrophosphohydrolase / Lipid A synthesis, UDP-2,3-diacylglucosamine pyroph... LPXH_ECOHS - UDP-2,3-diacylglucosamine hydrolase OS=Escherichia coli O9:H4 (strain HS) GN=lpxH PE=3 SV=1 gi\|73671342\|gb\|A... - LpxH [Escherichia coli]	252.0	[0..1]	[240..1]

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Predicted Domain #1

Region A:
Residues: [1-240]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATLFIADLH LCVEEPAITA GFLRFLAGEA RKADALYILG DLFEAWIGDD DPNPLHRQMA  60
   61 AAIKAVSDSG VPCYFIHGNR DFLLGKRFAR ESGMTLLPEE KVLELYGRRV LIMHGDTLCT 120
  121 DDAGYQAFRA KVHKPWLQML FLALPLFVRK RIAARMRANS KEANSSKSLA IMDVNQNAVV 180
  181 SAMEKHQVQW LIHGHTHRPA VHELIANQQP AFRVVLGAWH TEGSMVKVTA DDVELIHFPF 240
  241

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	18.154902
Match:	1ii7A
Description:	Mre11
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.39852585255405	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	1.08477762279171	bayes_pls_golite062009
phosphoprotein phosphatase activity	1.05109559862153	bayes_pls_golite062009
protein serine/threonine phosphatase activity	0.877022343553428	bayes_pls_golite062009
phosphoric ester hydrolase activity	0.762880369401283	bayes_pls_golite062009
phosphatase activity	0.638806808750323	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: