YRC Public Data Repository - Protein Structure Prediction

Protein:	THYX_CAMJR
Organism:	Campylobacter jejuni RM1221
Length:	207 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for THYX_CAMJR.

Description	E-value	Query Range	Subject Range
gi\|168214714, gi... - gi\|170713810\|gb\|EDT25992.1\| thymidylate synthase, flavin-dependent [Clostridium perfringens CPE str.... gi\|182380042, gi... - gi\|182380042\|gb\|EDT77521.1\| thymidylate synthase, flavin-dependent [Clostridium perfringens NCTC 823... gi\|169297747, gi... - gi\|169344136\|ref\|ZP_02865119.1\| thymidylate synthase, flavin-dependent [Clostridium perfringens C st... gi\|182626994, gi... - gi\|182626994\|ref\|ZP_02954724.1\| thymidylate synthase, flavin-dependent [Clostridium perfringens D st... THYX_CLOPE - Thymidylate synthase ThyX OS=Clostridium perfringens (strain 13 / Type A) GN=thyX PE=3 SV=1 gi\|170661745, gi... - gi\|170661745\|gb\|EDT14428.1\| thymidylate synthase, flavin-dependent [Clostridium perfringens E str. J... gi\|170710771, gi... - gi\|170710771\|gb\|EDT22953.1\| thymidylate synthase, flavin-dependent [Clostridium perfringens B str. A... gi\|110801337, gi... - gi\|110801337\|ref\|YP_697114.1\| FAD-dependent thymidylate synthase [Clostridium perfringens ATCC 13124... THYX_CLOPE - Thymidylate synthase thyX OS=Clostridium perfringens GN=thyX PE=3 SV=1	245.0	[0..1]	[201..2]
THYX_CLOTE - Thymidylate synthase ThyX OS=Clostridium tetani (strain Massachusetts / E88) GN=thyX PE=3 SV=1 THYX_CLOTE - Thymidylate synthase thyX OS=Clostridium tetani GN=thyX PE=3 SV=1	245.0	[0..1]	[205..8]
gi\|110803744, gi... - gi\|110803744\|ref\|YP_699683.1\| FAD-dependent thymidylate synthase [Clostridium perfringens SM101], gi...	243.0	[0..1]	[201..2]
gi\|153952167, gi... - gi\|153952167\|ref\|YP_001397296.1\| FAD-dependent thymidylate synthase [Campylobacter jejuni subsp. doy...	241.0	[0..1]	[207..1]
gi\|115249057, gi... - gi\|126697620\|ref\|YP_001086517.1\| FAD-dependent thymidylate synthase [Clostridium difficile 630], gi\|... gi\|255099213 - gi\|255099213\|ref\|ZP_05328190.1\| FAD-dependent thymidylate synthase [Clostridium difficile QCD-63q42] gi\|255304996 - gi\|255304996\|ref\|ZP_05349168.1\| FAD-dependent thymidylate synthase [Clostridium difficile ATCC 43255... gi\|255654142 - gi\|255654142\|ref\|ZP_05399551.1\| FAD-dependent thymidylate synthase [Clostridium difficile QCD-23m63]	238.0	[0..1]	[204..1]
gi\|57169018, gi\|... - gi\|57169018\|ref\|ZP_00368146.1\| Thymidylate synthase complementing protein superfamily [Campylobacter...	237.0	[0..1]	[206..1]
gi\|34558802 - gi\|34558802\|gb\|AAQ75147.1\| thymidylate synthase complementing protein superfamily [Alvinella pompeja...	234.0	[0..1]	[203..5]
THYX_WOLSU - Thymidylate synthase ThyX OS=Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC ... THYX_WOLSU - Thymidylate synthase thyX OS=Wolinella succinogenes GN=thyX PE=3 SV=1	234.0	[0..1]	[205..1]
gi\|222823057, gi... - gi\|57241673\|ref\|ZP_00369618.1\| Thymidylate synthase complementing protein superfamily [Campylobacter...	232.0	[0..1]	[205..1]
THYX_GEOSL - Thymidylate synthase ThyX OS=Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) GN=thyX ... THYX_GEOSL - Thymidylate synthase thyX OS=Geobacter sulfurreducens GN=thyX PE=3 SV=1	231.0	[0..1]	[201..1]

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Predicted Domain #1

Region A:
Residues: [1-207]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQITLLFHTP LSVCSHATRT CWQSFEKGDC GGEKDKELID RVGNKFKHAS TLEHLNYTFY  60
   61 IQGISRACLQ EVARHRHTSP SVKSTRYTLK ELRNEAEFKI GDFENASRYL VLCGNEEVDN 120
  121 ASIKALENLR TILQKSISLD IAKYCLPESY KTELTLTINA RSLQNFISLR SSKSALWEIR 180
  181 NLANALFEAL PQEHKFIFEH CLHKDIE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	59.045757
Match:	2af6A
Description:	Crystal structure of Mycobacterium tuberculosis Flavin dependent thymidylate synthase (Mtb ThyX) in the presence of co-factor FAD and substrate analog 5-Bromo-2'-Deoxyuridine-5'-Monophosphate (BrdUMP)
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits