YRC Public Data Repository - Protein Structure Prediction

Protein:	HIS6_CAMJR
Organism:	Campylobacter jejuni RM1221
Length:	255 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HIS6_CAMJR.

Description	E-value	Query Range	Subject Range
gi\|89083520, gi\|... - gi\|89092432\|ref\|ZP_01165386.1\| imidazole glycerol phosphate synthase subunit HisF [Oceanospirillum s...	209.0	[0..2]	[255..3]
HIS6_ALCBS - Imidazole glycerol phosphate synthase subunit HisF OS=Alcanivorax borkumensis (strain ATCC 700651 / ...	209.0	[0..2]	[255..3]
HIS6_CUPMC - Imidazole glycerol phosphate synthase subunit HisF OS=Cupriavidus metallidurans (strain ATCC 43123 /...	208.0	[0..1]	[255..1]
HIS6_NITEC - Imidazole glycerol phosphate synthase subunit HisF OS=Nitrosomonas eutropha (strain C91) GN=hisF PE=...	208.0	[0..2]	[255..3]
HIS6_GEODF - Imidazole glycerol phosphate synthase subunit HisF OS=Geobacter daltonii (strain DSM 22248 / JCM 158...	207.0	[0..1]	[255..1]
HIS6_GEOSL - Imidazole glycerol phosphate synthase subunit HisF OS=Geobacter sulfurreducens (strain ATCC 51573 / ... HIS6_GEOSL - Imidazole glycerol phosphate synthase subunit HisF OS=Geobacter sulfurreducens GN=hisF PE=3 SV=1	207.0	[0..1]	[255..1]
gi\|94499843, gi\|... - gi\|94499843\|ref\|ZP_01306379.1\| Imidazoleglycerol-phosphate synthase [Oceanobacter sp. RED65], gi\|944...	206.0	[0..2]	[255..3]
HIS6_NITEU - Imidazole glycerol phosphate synthase subunit HisF OS=Nitrosomonas europaea GN=hisF PE=3 SV=1 HIS6_NITEU - Imidazole glycerol phosphate synthase subunit HisF OS=Nitrosomonas europaea (strain ATCC 19718 / NBR...	206.0	[0..2]	[255..3]
gi\|118581458, gi... - gi\|71839788\|ref\|ZP_00679530.1\| Histidine biosynthesis protein HisF [Pelobacter propionicus DSM 2379]...	206.0	[0..1]	[255..1]
HIS6_CUPPJ - Imidazole glycerol phosphate synthase subunit HisF OS=Cupriavidus pinatubonensis (strain JMP 134 / L...	206.0	[0..1]	[255..1]

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Predicted Domain #1

Region A:
Residues: [1-255]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLTKRIIACL DVKDGRVVKG TQFKNHKDMG DIIELARYYS QNGIDELVFY DIAASARKER  60
   61 ISREWVSEVA KNINISFCVA GGIKSEEDAA ELLANGADKI SINSPALNDP SLITRLAKSF 120
  121 GVQCVVVGID SFKDENGNLK VFQYTGDEKT SKHSGKSTLE WVKKVQDLGA GEIVLNMMNQ 180
  181 DGVKNGYDLE QLEAVYKICK VPLIASGGAG KMEHFLEAFK LGIDGALAAS VFHQKLIDIK 240
  241 ELKIYLKNQG LSIRI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	42.09691
Match:	1thfD
Description:	Cyclase subunit (or domain) of imidazoleglycerolphosphate synthase HisF
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
imidazoleglycerol-phosphate synthase activity	8.63799159510181	bayes_pls_golite062009
catalytic activity	2.44231061702877	bayes_pls_golite062009
transferase activity, transferring pentosyl groups	1.13340776845419	bayes_pls_golite062009
indole-3-glycerol-phosphate synthase activity	0.549444136526559	bayes_pls_golite062009
tryptophan synthase activity	0.426391242491024	bayes_pls_golite062009
lyase activity	0.258652421339738	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: