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View Structure Prediction Details

Protein: twk-9
Organism: Caenorhabditis elegans
Length: 568 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for twk-9.

Description E-value Query
Range
Subject
Range
HGNC:16882|MIM:6... - activated cyclic nucleotide-gated potassium channel 4
HCN4 - hyperpolarization activated cyclic nucleotide-gated potassium channel 4
gi|225000856, gi... - gi|225000856|gb|AAI72471.1| Hyperpolarization activated cyclic nucleotide-gated potassium channel 4 ...
203.0 [0..142] [559..248]

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Predicted Domain #1
Region A:
Residues: [1-406]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKCSFHIPEK YQWASTLFVH VALIAGVAVY TVFGALSMQW LESPDRVRAL LKRELKPVES  60
   61 LPPPPSISGL PDRITRVYLG EELAILDPGV HECLERTILT LFHDTKCDPY SFEHLNIELI 120
  121 DRCYAEANVP IPEGYGGQPR KKIKNKEEEK DVIDETPAEK WSIGNSVIFA FTVITTIGYG 180
  181 HVAPETFEGR LFLIFYGVIG VPFTLLTIAD LGMFLTRFLK NLLTMARRFA HYLVKLYQKA 240
  241 KKQRNKSQKT SPVMPDSERS EVWNTGKEMK EMSMRTAREP GEGDEIEVIE NGNDENGKEE 300
  301 DEEEPENNEP RKTEESIALG ITFTCYLVAG AKILSVYEPE MDFFKALYFN FVTLTTIGLG 360
  361 DFVPKSFDYL LITLIYIGIG LALTTMAIEI AADLLKKLHY IGRKME

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 26.0
Match: 2a79B
Description: Mammalian Shaker Kv1.2 potassium channel- beta subunit complex
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [407-568]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NVGQAVVWFG GKKMTMKSLV KHLGDQFNIP EEELANFDMS AFVDNAIKVE KGEIATLRKP  60
   61 PTPPVVFRER AFSFSNVRNS SESALKYVDD NRFSKTTQPT IYTVIIHETT RTIDTLHNLA 120
  121 DAIRRDPSIP RLDLDVHYLT DMSAPTSFDE NYLRTYTNAR RK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.045757
Match: 2q0aA
Description: No description for 2q0aA was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle