YRC Public Data Repository - Protein Structure Prediction

Protein:	POLR3K
Organism:	Homo sapiens
Length:	108 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for POLR3K.

Description	E-value	Query Range	Subject Range
gi\|73959879 - gi\|73959879\|ref\|XP_854405.1\| PREDICTED: similar to DNA-directed RNA polymerases III 12.5 kDa polypep...	2.0E-33	[1..108]	[25..132]
gi\|12862220 - gi\|12862220\|dbj\|BAB32384.1\| unnamed protein product [Mus musculus]	2.0E-31	[1..108]	[1..108]
gi\|148237221, gi... - gi\|38511445\|gb\|AAH61683.1\| MGC68582 protein [Xenopus laevis], gi\|148237221\|ref\|NP_001083658.1\| DNA-d...	2.0E-31	[1..108]	[1..108]
gi\|21956651 - gi\|21956651\|gb\|AAM83406.1\| POLR3K [Sphoeroides nephelus]	3.0E-31	[1..108]	[1..108]
gi\|50540172, gi\|... - gi\|50540172\|ref\|NP_001002553.1\| polymerase (RNA) III (DNA directed) polypeptide K [Danio rerio], gi\|...	3.0E-31	[1..108]	[1..108]
POLR3K - polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa gi\|157929168, gi... - gi\|157929168\|gb\|ABW03869.1\| polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa [synthetic c... tr\|M3WAT9\|M3WAT9... - DNA-directed RNA polymerase subunit OS=Felis catus GN=POLR3K PE=3 SV=1	4.0E-31	[1..108]	[1..108]
gi\|47220062 - gi\|47220062\|emb\|CAG12210.1\| unnamed protein product [Tetraodon nigroviridis]	4.0E-31	[1..108]	[1..108]
gi\|62751522, gi\|... - gi\|89266864\|emb\|CAJ83854.1\| polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa [Xenopus tro...	1.0E-30	[1..108]	[1..108]
gi\|157118651, gi... - gi\|157118651\|ref\|XP_001659197.1\| DNA-directed RNA polymerases III 12.5 kDa polypeptide, putative [Ae...	1.0E-30	[1..108]	[1..108]

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Predicted Domain #1

Region A:
Residues: [1-108]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLLFCPGCGN GLIVEEGQRC HRFSCNTCPY VHNITRKVTN RKYPKLKEVD DVLGGAAAWE  60
   61 NVDSTAESCP KCEHPRAYFM QLQTRSADEP MTTFYKCCNA QCGHRWRD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	20.0
Match:	1i3qI
Description:	RBP9 subunit of RNA polymerase II
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
DNA-directed RNA polymerase activity	8.87472871386782	bayes_pls_golite062009
RNA polymerase activity	8.87472871386782	bayes_pls_golite062009
nucleotidyltransferase activity	6.30881681756207	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	5.23548851881217	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	4.66342402708121	bayes_pls_golite062009
transferase activity	3.6513313586587	bayes_pls_golite062009
transcription regulator activity	3.36253105801209	bayes_pls_golite062009
binding	2.58311326284197	bayes_pls_golite062009
transcription elongation regulator activity	2.03339710864117	bayes_pls_golite062009
nucleic acid binding	1.8086747972572	bayes_pls_golite062009
DNA binding	1.76634962183736	bayes_pls_golite062009
DNA primase activity	1.01743034310838	bayes_pls_golite062009
protein binding	0.764662055834369	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.672750759084994	bayes_pls_golite062009
catalytic activity	0.434839928397784	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: