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View Structure Prediction Details

Protein: gi|22136684, gi|...
Organism: Arabidopsis thaliana
Length: 596 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|22136684, gi|....

Description E-value Query
Range
Subject
Range
PUR9_ALTMD - Bifunctional purine biosynthesis protein PurH OS=Alteromonas macleodii (strain DSM 17117 / Deep ecot...
PUR9_ALTMD - Bifunctional purine biosynthesis protein PurH OS=Alteromonas mediterranea (strain DSM 17117 / CIP 11...
734.0 [0..65] [596..1]

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Predicted Domain #1
Region A:
Residues: [1-69]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSSAATATS VSARSGDILC GLFRKKSVAP FRFTQPVYRT SLCPSFVAVR AMAESQTAQR  60
   61 NQPQSSGSS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 45.045757
Match: 1bxrA
Description: Carbamoyl phosphate synthetase, large subunit connection domain; Carbamoyl phosphate synthetase, large subunit allosteric, C-terminal domain; Carbamoyl phosphate synthetase (CPS), large subunit PreATP-grasp domains; Carbamoyl phosphate synthetase (CPS), large subunit ATP-binding domains
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [70-596]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GEKQALISLS DKRDLASLGN GLQELGYTIV STGGTASTLE NAGVSVTKVE KLTHFPEMLD  60
   61 GRVKTLHPNI HGGILARRDV EHHMEALNEH GIGTFDVVVV NLYPFYEKVT APGGISFEDG 120
  121 IENIDIGGPA MIRAAAKNHK DVLIVVDSGD YQAVLEYLKG GQSDQQFRRK LAWKAFQHVA 180
  181 AYDSAVSEWL WKQTEGKEKF PPSFTVPLVL KSSLRYGENP HQKAAFYVDK SLAEVNAGGI 240
  241 ATAIQHHGKE MSYNNYLDAD AAWNCVSEFE NPTCVVVKHT NPCGVASRDD ILEAYRLAVK 300
  301 ADPVSAFGGI VAFNVEVDEV LAREIREFRS PTDGETRMFY EIVVAPKYTA KGLEVLKGKS 360
  361 KTLRILEAKK NDQGKLSLRQ VGGGWLAQDS DDLTPEDISF NSVSDKTPTE SELADAKFAW 420
  421 LCVKHVKSNA IVIAKNNCML GMGSGQPNRV ESLRIAFKKA GEEAKGAALA SDAFFPFAWK 480
  481 DAVEEACQMG IGVIAEPGGS IRDQDAIDCC KKYGVSLLFT NVRHFRH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 159.0
Match: 1p4rA
Description: Crystal Structure of Human ATIC in complex with folate-based inhibitor BW1540U88UD
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
IMP cyclohydrolase activity 2.44338227123463 bayes_pls_golite062009
phosphoribosylaminoimidazolecarboxamide formyltransferase activity 2.17104645465987 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 1.79965948308471 bayes_pls_golite062009
catalytic activity 1.70756445127105 bayes_pls_golite062009
hydroxymethyl-, formyl- and related transferase activity 1.51378035087272 bayes_pls_golite062009
glycine hydroxymethyltransferase activity 1.19388272840449 bayes_pls_golite062009
deaminase activity 1.16510523659661 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1.03324558866637 bayes_pls_golite062009
cytidine deaminase activity 0.870445440530128 bayes_pls_golite062009
binding 0.46651845554048 bayes_pls_golite062009
hydrolase activity 0.339145951258927 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle