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View Structure Prediction Details

Protein: gi|55624456
Organism: Pan troglodytes
Length: 211 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|55624456.

Description E-value Query
Range
Subject
Range
gi|1172123, gi|1... - gi|7110601|ref|NP_034405.1| glial cell line derived neurotrophic factor [Mus musculus], gi|1669571|d...
1.0E-81 [1..211] [30..240]
gi|50762337 - gi|50762337|ref|XP_425018.1| PREDICTED: similar to glial cell line-derived neurotrophic factor long ...
2.0E-81 [1..211] [1..218]
gi|114600517 - gi|114600517|ref|XP_001143054.1| PREDICTED: similar to neurotrophic factor isoform 3 [Pan troglodyte...
gi|119576368 - gi|119576368|gb|EAW55964.1| glial cell derived neurotrophic factor, isoform CRA_b [Homo sapiens]
1.0E-80 [1..211] [18..228]
gi|60826762 - gi|60826762|gb|AAX36770.1| glial cell derived neurotrophic factor [synthetic construct]
2.0E-80 [1..211] [1..211]
gi|109077030 - gi|109077030|ref|XP_001094714.1| PREDICTED: similar to glial cell line derived neurotrophic factor [...
3.0E-80 [1..211] [154..364]
gi|73954307 - gi|73954307|ref|XP_546342.2| PREDICTED: similar to glial cell derived neurotrophic factor isoform 1 ...
3.0E-79 [1..211] [55..265]
GDNF_RAT - Glial cell line-derived neurotrophic factor OS=Rattus norvegicus GN=Gdnf PE=1 SV=1
3.0E-79 [1..211] [1..211]
gi|912789 - gi|912789|gb|AAB33891.1| glial cell line-derived neurotrophic factor GDNF633 [Rattus sp.]
2.0E-78 [1..211] [1..211]

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Predicted Domain #1
Region A:
Residues: [1-63]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKLWDVVAVC LVLLHTASAF PLPAGKRPPE APAEDRSLGR RRAPFALSSD SNMPEDYPDQ  60
   61 FDD

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.375 N/A N/A a.60.9 lambda integrase-like, N-terminal domain
View Download 0.217 N/A N/A a.50.1 Anaphylotoxins (complement system)
View Download 0.205 N/A N/A d.58.49 YajQ-like

Predicted Domain #2
Region A:
Residues: [64-211]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VMDFIQATIK RLKRSPDKQM AVLPRRERNR QAAAANPENS RGKGRRGQRG KNRGCVLTAI  60
   61 HLNVTDLGLG YETKEELIFR YCSGSCDAAE TTYDKILKNL SRNRRLVSDK VGQACCRPIA 120
  121 FDDDLSFLDD NLVYHILRKH SAKRCGCI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 45.39794
Match: 1agqA
Description: Glial cell-derived neurotrophic factor, GDNF
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
vascular endothelial growth factor receptor 1 binding 4.88004110368356 bayes_pls_golite062009
receptor serine/threonine kinase binding 4.8369569327215 bayes_pls_golite062009
receptor binding 4.70889547404918 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase binding 4.69128752159226 bayes_pls_golite062009
transforming growth factor beta receptor binding 4.69128752159226 bayes_pls_golite062009
glial cell line-derived neurotrophic factor receptor binding 4.199474917569 bayes_pls_golite062009
growth factor activity 4.01406832911234 bayes_pls_golite062009
cytokine activity 3.61376517935324 bayes_pls_golite062009
vascular endothelial growth factor receptor binding 3.16494996397951 bayes_pls_golite062009
protein binding 3.16282476674164 bayes_pls_golite062009
vascular endothelial growth factor receptor 2 binding 3.0813162230094 bayes_pls_golite062009
type II transforming growth factor beta receptor binding 3.06631842262117 bayes_pls_golite062009
cell surface binding 2.9725198156666 bayes_pls_golite062009
glycosaminoglycan binding 2.49731836866959 bayes_pls_golite062009
growth factor binding 2.41942870726502 bayes_pls_golite062009
binding 2.37954321554411 bayes_pls_golite062009
heparin binding 2.11784489374422 bayes_pls_golite062009
hormone activity 2.10500409590202 bayes_pls_golite062009
platelet-derived growth factor receptor binding 1.78479767888975 bayes_pls_golite062009
protein dimerization activity 1.44846386076063 bayes_pls_golite062009
fibronectin binding 1.3732716084502 bayes_pls_golite062009
platelet-derived growth factor binding 1.18476084022243 bayes_pls_golite062009
polysaccharide binding 1.16191864095271 bayes_pls_golite062009
protein homodimerization activity 1.13743310822539 bayes_pls_golite062009
collagen binding 1.00551310632663 bayes_pls_golite062009
identical protein binding 1.0030262164995 bayes_pls_golite062009
morphogen activity 0.91146826241391 bayes_pls_golite062009
pattern binding 0.90497366619649 bayes_pls_golite062009
neurotrophin receptor binding 0.81172494974121 bayes_pls_golite062009
vascular endothelial growth factor receptor 3 binding 0.772832351269279 bayes_pls_golite062009
protein heterodimerization activity 0.408562885230686 bayes_pls_golite062009
transcription activator activity 0.290946570822357 bayes_pls_golite062009
catalytic activity 0.105223830172599 bayes_pls_golite062009
signal transducer activity 0.102347067903142 bayes_pls_golite062009
molecular transducer activity 0.102347067903142 bayes_pls_golite062009
transcription regulator activity 0.0706173408709216 bayes_pls_golite062009
carbohydrate binding 0.0235054088545197 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle