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View Structure Prediction Details

Protein: PNP
Organism: Homo sapiens
Length: 289 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PNP.

Description E-value Query
Range
Subject
Range
gi|109082685 - gi|109082685|ref|XP_001092508.1| PREDICTED: purine nucleoside phosphorylase [Macaca mulatta]
0.0 [1..289] [1..289]
PNP - purine nucleoside phosphorylase
0.0 [1..289] [1..289]
gi|114651772 - gi|114651772|ref|XP_001140576.1| PREDICTED: hypothetical protein isoform 2 [Pan troglodytes]
0.0 [1..289] [1..289]
gi|34809937, gi|... - gi|34809943|pdb|1LVU|F Chain F, Crystal Structure Of Calf Spleen Purine Nucleoside Phosphorylase In ...
0.0 [1..283] [1..283]

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Predicted Domain #1
Region A:
Residues: [1-289]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MENGYTYEDY KNTAEWLLSH TKHRPQVAII CGSGLGGLTD KLTQAQIFDY GEIPNFPRST  60
   61 VPGHAGRLVF GFLNGRACVM MQGRFHMYEG YPLWKVTFPV RVFHLLGVDT LVVTNAAGGL 120
  121 NPKFEVGDIM LIRDHINLPG FSGQNPLRGP NDERFGDRFP AMSDAYDRTM RQRALSTWKQ 180
  181 MGEQRELQEG TYVMVAGPSF ETVAECRVLQ KLGADAVGMS TVPEVIVARH CGLRVFGFSL 240
  241 ITNKVIMDYE SLEKANHEEV LAAGKQAAQK LEQFVSILMA SIPLPDKAS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 105.0
Match: 1pf7E
Description: CRYSTAL STRUCTURE OF HUMAN PNP COMPLEXED WITH IMMUCILLIN H
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
S-methyl-5-thioadenosine phosphorylase activity 3.89303327575747 bayes_pls_golite062009
purine-nucleoside phosphorylase activity 3.68206997938506 bayes_pls_golite062009
transferase activity, transferring glycosyl groups 3.66765825367784 bayes_pls_golite062009
hydrolase activity, hydrolyzing N-glycosyl compounds 2.28129906270728 bayes_pls_golite062009
catalytic activity 2.18268586151113 bayes_pls_golite062009
transferase activity, transferring pentosyl groups 2.01261001022129 bayes_pls_golite062009
binding 1.58090357201399 bayes_pls_golite062009
nicotinamide riboside hydrolase activity 1.38986205931368 bayes_pls_golite062009
hydrolase activity, acting on glycosyl bonds 1.38135070025071 bayes_pls_golite062009
protein binding 1.28444435808613 bayes_pls_golite062009
nucleoside binding 1.11256863177576 bayes_pls_golite062009
purine binding 1.00226077276304 bayes_pls_golite062009
nucleobase binding 0.914372836742171 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle