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View Structure Prediction Details

Protein: gi|78100079, gi|...
Organism: Homo sapiens
Length: 133 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|78100079, gi|....

Description E-value Query
Range
Subject
Range
gi|30025670 - gi|30025670|gb|AAP04419.1| interleukin-2 [Peromyscus maniculatus]
218.0 [0..1] [131..21]
gi|208188 - gi|208188|gb|AAA72358.1| fusion protein
218.0 [0..1] [133..329]

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Predicted Domain #1
Region A:
Residues: [1-133]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 APTSSSTKKT QLQLEHLLLD LQMILNGINN YKNPKLTRML TFKFYMPKKA TELKHLQCLE  60
   61 EELKPLEEVL NLAQSKNFHL RPRDLISNIN VIVLELKGSE TTFMCEYADE TATIVEFLNR 120
  121 WITFCQSIIS TLT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 50.154902
Match: 1m47A
Description: Interleukin-2 (IL-2)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cytokine receptor binding 6.47223189691244 bayes_pls_golite062009
receptor binding 5.3304255990112 bayes_pls_golite062009
cytokine activity 5.1883241815362 bayes_pls_golite062009
growth factor activity 4.92105782010612 bayes_pls_golite062009
interleukin-10 receptor binding 3.75864942466928 bayes_pls_golite062009
protein binding 3.26483713001551 bayes_pls_golite062009
growth hormone activity 2.71439518801599 bayes_pls_golite062009
hormone activity 2.52921243340076 bayes_pls_golite062009
binding 2.48265117231403 bayes_pls_golite062009
prolactin receptor binding 2.45721634350294 bayes_pls_golite062009
interleukin-6 receptor binding 2.37535614986843 bayes_pls_golite062009
interleukin-12 binding 2.17594406686308 bayes_pls_golite062009
interleukin-27 binding 1.83998174953013 bayes_pls_golite062009
ciliary neurotrophic factor receptor binding 1.79326213321183 bayes_pls_golite062009
interleukin-2 receptor binding 1.24568403220915 bayes_pls_golite062009
interleukin-12 beta subunit binding 1.10825259714222 bayes_pls_golite062009
erythropoietin receptor binding 0.77580300541347 bayes_pls_golite062009
interleukin-4 receptor binding 0.390049814001731 bayes_pls_golite062009
interleukin-3 receptor binding 0.264629367313661 bayes_pls_golite062009
catalytic activity 0.246169290135575 bayes_pls_golite062009
interleukin-12 receptor binding 0.218984052557791 bayes_pls_golite062009
transcription regulator activity 0.010318258615897 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle