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View Structure Prediction Details

Protein: gi|24935322, gi|...
Organism: Plasmodium falciparum
Length: 912 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|24935322, gi|....

Description E-value Query
Range
Subject
Range
gi|83033053 - gi|83033053|ref|XP_729309.1| DNA ligase 1 [Plasmodium yoelii yoelii str. 17XNL]
gi|23486709 - gi|23486709|gb|EAA20874.1| DNA ligase 1 [Plasmodium yoelii yoelii]
692.0 [0..83] [912..8]
gi|56497113 - gi|56497113|emb|CAH97995.1| DNA ligase 1, putative [Plasmodium berghei]
gi|68070421 - gi|68070421|ref|XP_677122.1| DNA ligase 1 [Plasmodium berghei strain ANKA]
686.0 [0..83] [912..80]
LIG1 - ligase I, DNA, ATP-dependent
594.0 [0..25] [911..2]
gi|114678168, gi... - gi|114678168|ref|XP_001170212.1| PREDICTED: DNA ligase I isoform 4 [Pan troglodytes], gi|114678166|r...
592.0 [0..25] [911..2]
gi|55235559, gi|... - gi|58393333|ref|XP_319999.2| ENSANGP00000010547 [Anopheles gambiae str. PEST], gi|55235559|gb|EAA150...
592.0 [0..300] [911..36]
gi|109125447 - gi|109125447|ref|XP_001111346.1| PREDICTED: DNA ligase I [Macaca mulatta]
589.0 [0..25] [911..2]
DNLI1_XENLA - DNA ligase 1 OS=Xenopus laevis GN=lig1 PE=2 SV=1
587.0 [0..11] [909..145]
gi|68356762 - gi|68356762|ref|XP_685406.1| PREDICTED: similar to ligase I [Danio rerio]
579.0 [0..297] [907..14]
gi|45185533, gi|... - gi|45185533|ref|NP_983249.1| ACL155Wp [Ashbya gossypii ATCC 10895], gi|44981251|gb|AAS51073.1| ACL15...
gi|44981251 - gi|44981251|gb|AAS51073.1| ACL155Wp [Ashbya gossypii ATCC 10895]
578.0 [0..270] [894..68]

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Predicted Domain #1
Region A:
Residues: [1-217]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNFLILVVLI KMVVCKIINY VRSDYNFMLS FLRTRKIFSH KKIYFNFKVS KNITKNSSSN  60
   61 SYSDILKCFS FPRKGTNDKT KENETFEKGE VKEEEEEKDK NVKRKIINES SKNKRAKVKN 120
  121 ENDVIKKGSL FNCVVREDEK VNDLSSPKFN PVHFNINDLY LSEKDKEKHK FKDSLLFTFL 180
  181 TNAFNQIEEL KGSGTGSKKN VSIILSNIFR VLIYYSP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [218-912]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDLIPAVYIT LNKVAPDYLN VEAGVGEALI LKTMSEAYSR TESSIKKDLQ QIEDLGIIAE  60
   61 NCSCKMRTIF PLPRLTIQSV FHELKSIPNL IGSNSQQKKR EVIKKLLVSA KTSEAKYIVR 120
  121 FLQQRLRIGV NSATVVQALS YAFILTRPSI PDDIIKRGKE INENLINGKL DGTNNLINKS 180
  181 NNKTEEWLTQ SGDRNCIKEE NLNDELLSKD DINKCENMDS LINEIRIRNE KINKPNIFYN 240
  241 LIEKVGDTRL LPLFFKELKN IYCEENNDID IFECMEKSVK SALCELPNIE IIIQNLLNGD 300
  301 DMNTLSKKCT VKTGIPVQPM LAKPTKGVQE VLDRFNNVTF TCEYKYDGER AQIHYIDKDN 360
  361 IKIFSRNLET MTEKYPDVIQ IIKDQIGENV KECIIDSEVV AYDIVNNKIL PFQVLTTRKR 420
  421 KDVDIENIKV KVCLFPFDLI CCNGIPVIKE PLAVRRKLLY SLLKSKDGVL SYATHSEMNN 480
  481 IEDIDMFLQD AIENNCEGLM VKTLVENASY EPSRRSLNWL KVKKDYVEGL SDSVDLVPIA 540
  541 GYYGKGKRSG VYGAFVLAAY NSETENFQTV CKAGTGFSDE ILSTLYETLS EKIIPNKKSY 600
  601 YEVSDKLNPD VWFDAHYVWE VKAADLSLSP VHTAAIGIYA DDKGIGLRFP RFLRLREDKN 660
  661 AEQATTTQQI VDFYEAQFSS NKNKNIDYND DTESE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 165.0
Match: 1x9nA
Description: Crystal Structure of Human DNA Ligase I bound to 5'-adenylated, nicked DNA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
catalytic activity 1.62364941193231 bayes_pls_golite062009
ligase activity 0.85267344624274 bayes_pls_golite062009
ligase activity, forming phosphoric ester bonds 0.81722565837488 bayes_pls_golite062009
DNA ligase activity 0.712397444123471 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle