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View Structure Prediction Details

Protein: feh-1
Organism: Caenorhabditis elegans
Length: 554 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for feh-1.

Description E-value Query
Range
Subject
Range
gi|18074055 - gi|18074055|emb|CAC87812.1| FEH-1 protein [Caenorhabditis elegans]
451.0 [0..1] [554..24]

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Predicted Domain #1
Region A:
Residues: [1-111]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVDYSSQDF RQSLAAIDQA SRDGAISRGE DGVRVRQIGD TTIMTEHRDP YSFYWQLDQA  60
   61 RREAESPPRR PPPTDYVIDE EEEVLETVYS PEADDVMFEN QYRRPVRHPL P

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [112-215]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPPPIMEEEP KDLPPGWEKH EDPQGYSYYW HVDSGTIQRQ PPPPVNRETQ ADAPPPQIIQ  60
   61 LPPQQPVIEE HAFKQTTTKR RIEQDEMSER EIEDVAMIEN GDTY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.69897
Match: 1tk7A
Description: NMR structure of WW domains (WW3-4) from Suppressor of Deltex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.839261228716609 bayes_pls_golite062009
protein binding 0.356989281623449 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [216-371]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HKPVRFAVRS LGWTDISEDE LTAEKSSRAV NRAIVDLTTR SDIDSIPKWG DGRELIMELD  60
   61 DNELALLDPD SMNVIHSERI QAIRVWGVGR DNGRDFAYVS RDRGTRRFMC HVFRCDTSAK 120
  121 TIANTLRDIC KRLMLHRRPS SLHAIESGEK RIVRSE

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.38
Match: 1m7eA
Description: Crystal structure of the phosphotyrosine binding domain(PTB) of mouse Disabled 2(Dab2):implications for Reeling signaling
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.37952825516509 bayes_pls_golite062009
protein binding 0.845590096724432 bayes_pls_golite062009
cytoskeletal protein binding 0.0992846891421419 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [372-554]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GLTAPIDEPR KVIRCHFLGV TQVPKATGIE ILNEAVDRLV SQVRSERWIL ADVSIAPSTI  60
   61 AIVEVNGQQI AECRVRYLSF LGIGRDVKHC AFIMQTSSES FMCYVFHVEP NAAAMAKMVE 120
  121 AACKLRYQKV LDAHSSSRHH SGMSIHGQHP PSTYHGKGWT ETFRDAFGSV TSRMVPSRSA 180
  181 QRL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.30103
Match: 1wguA
Description: Solution Structure of the C-terminal Phosphotyrosine Interaction Domain of APBB2 from Mouse
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.50787782811555 bayes_pls_golite062009
protein binding 1.00964194060904 bayes_pls_golite062009
cytoskeletal protein binding 0.22504145765203 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle