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View Structure Prediction Details

Protein: feh-1
Organism: Caenorhabditis elegans
Length: 554 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for feh-1.

Description E-value Query
Range
Subject
Range
gi|18074055 - gi|18074055|emb|CAC87812.1| FEH-1 protein [Caenorhabditis elegans]
451.0 [0..1] [554..24]

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Predicted Domain #1
Region A:
Residues: [1-111]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVDYSSQDF RQSLAAIDQA SRDGAISRGE DGVRVRQIGD TTIMTEHRDP YSFYWQLDQA  60
   61 RREAESPPRR PPPTDYVIDE EEEVLETVYS PEADDVMFEN QYRRPVRHPL P

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [112-215]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPPPIMEEEP KDLPPGWEKH EDPQGYSYYW HVDSGTIQRQ PPPPVNRETQ ADAPPPQIIQ  60
   61 LPPQQPVIEE HAFKQTTTKR RIEQDEMSER EIEDVAMIEN GDTY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.69897
Match: 1tk7A
Description: NMR structure of WW domains (WW3-4) from Suppressor of Deltex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.839261228716609 bayes_pls_golite062009
protein binding 0.356989281623449 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [216-371]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HKPVRFAVRS LGWTDISEDE LTAEKSSRAV NRAIVDLTTR SDIDSIPKWG DGRELIMELD  60
   61 DNELALLDPD SMNVIHSERI QAIRVWGVGR DNGRDFAYVS RDRGTRRFMC HVFRCDTSAK 120
  121 TIANTLRDIC KRLMLHRRPS SLHAIESGEK RIVRSE

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.38
Match: 1m7eA
Description: Crystal structure of the phosphotyrosine binding domain(PTB) of mouse Disabled 2(Dab2):implications for Reeling signaling
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.37952825516509 bayes_pls_golite062009
protein binding 0.845590096724432 bayes_pls_golite062009
cytoskeletal protein binding 0.0992846891421419 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [372-554]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GLTAPIDEPR KVIRCHFLGV TQVPKATGIE ILNEAVDRLV SQVRSERWIL ADVSIAPSTI  60
   61 AIVEVNGQQI AECRVRYLSF LGIGRDVKHC AFIMQTSSES FMCYVFHVEP NAAAMAKMVE 120
  121 AACKLRYQKV LDAHSSSRHH SGMSIHGQHP PSTYHGKGWT ETFRDAFGSV TSRMVPSRSA 180
  181 QRL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.30103
Match: 1wguA
Description: Solution Structure of the C-terminal Phosphotyrosine Interaction Domain of APBB2 from Mouse
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.50787782811555 bayes_pls_golite062009
protein binding 1.00964194060904 bayes_pls_golite062009
cytoskeletal protein binding 0.22504145765203 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle