YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|7494400
Organism:	Plasmodium falciparum
Length:	338 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|7494400.

Description	E-value	Query Range	Subject Range
gi\|91687424, gi\|... - gi\|91783470\|ref\|YP_558676.1\| ribosomal large subunit pseudouridine synthase D [Burkholderia xenovora...	221.0	[0..24]	[330..55]
gi\|229330881, gi... - gi\|229498191\|ref\|ZP_04391888.1\| pseudouridine synthase, RluA family [Geobacillus sp. Y412MC52], gi\|2... gi\|56379523, gi\|... - gi\|56419681\|ref\|YP_146999.1\| hypothetical protein GK1146 [Geobacillus kaustophilus HTA426], gi\|56379... gi\|221087579, gi... - gi\|221087579\|ref\|ZP_03557116.1\| pseudouridine synthase, RluA family [Geobacillus sp. Y412MC61], gi\|2...	220.0	[0..34]	[307..3]
gi\|20807974, gi\|... - gi\|20807974\|ref\|NP_623145.1\| pseudouridylate synthase, 23S RNA-specific [Thermoanaerobacter tengcong... gi\|20807974 - gi\|20807974\|ref\|NP_623145.1\| Pseudouridylate synthase, 23S RNA-specific [Thermoanaerobacter tengcong...	219.0	[0..40]	[308..12]
gi\|116093351, gi... - gi\|62516048\|ref\|ZP_00387416.1\| COG0564: Pseudouridylate synthases, 23S RNA-specific [Lactobacillus d...	219.0	[0..35]	[338..3]
gi\|104774018, gi... - gi\|104774018\|ref\|YP_618998.1\| pseudouridylate synthase [Lactobacillus delbrueckii subsp. bulgaricus ...	218.0	[0..35]	[338..3]
gi\|76587739, gi\|... - gi\|76796894\|ref\|ZP_00779243.1\| Pseudouridine synthase, RluD [Thermoanaerobacter ethanolicus ATCC 332...	217.0	[0..40]	[308..13]
gi\|15615105, gi\|... - gi\|15615105\|ref\|NP_243408.1\| hypothetical protein BH2542 [Bacillus halodurans C-125], gi\|10175162\|db... gi\|25322336 - pir\|\|F83967 hypothetical protein BH2542 [imported] - Bacillus halodurans (strain C-125)	216.0	[0..35]	[307..5]
gi\|24379309, gi\|... - gi\|24379309\|ref\|NP_721264.1\| putative pseudouridylate synthase [Streptococcus mutans UA159], gi\|2437...	214.0	[0..38]	[338..2]
gi\|47570307, gi\|... - gi\|47570307\|ref\|ZP_00240954.1\| ribosomal large subunit pseudouridine synthase D [Bacillus cereus G92...	214.0	[0..34]	[307..4]
gi\|55736588 - gb\|AAV60230.1\| ribosomal large subunit pseudouridine synthase D [Streptococcus thermophilus LMG 1831... gi\|55736588, gi\|... - gi\|55820603\|ref\|YP_139045.1\| ribosomal large subunit pseudouridine synthase D [Streptococcus thermop...	214.0	[0..38]	[338..2]

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Predicted Domain #1

Region A:
Residues: [1-338]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MICSNLSLLR YVHLVYYFII ISFCIHNNIS CFNVNLTKTN EDANIIRLNK LISMKRNISR  60
   61 RKSDEFIKDG KVKINNKIIT NPGTHVHIGK DSLRIYDKKI KLTNIINMIK QNENKLHKWI 120
  121 VLHKPKGLLC TSNDEKNRKS IYTLFPEEML QKYRLVTVGR LDRNTSGVLL LTNDYAWVNK 180
  181 LTHPKYQRIR TYRVHIEGPV KMNALKELAR GIYLEEDEKT QPKKIYNYKE SREKSNIDDK 240
  241 KKKKMSKMKK KTNPAFIEIL REEKIKIKED TKKITVLNIS IKEGRNRQIR KMFQQINQPV 300
  301 IKIKRTSFEN ITLKNIYFPK QYRELNQKEV NDLKLRNF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	40.30103
Match:	1vioA
Description:	Crystal structure of pseudouridylate synthase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
pseudouridine synthase activity	5.60483019625575	bayes_pls_golite062009
intramolecular transferase activity	4.62815459483632	bayes_pls_golite062009
isomerase activity	3.43067391737824	bayes_pls_golite062009
catalytic activity	2.39224964671205	bayes_pls_golite062009
structural constituent of ribosome	1.93805098366683	bayes_pls_golite062009
structural molecule activity	1.65902435754631	bayes_pls_golite062009
RNA binding	0.351909066993469	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: