YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|45434769, gi\|...
Organism:	Yersinia pestis biovar Microtus str. 91001
Length:	405 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|45434769, gi|....

Description	E-value	Query Range	Subject Range
gi\|77630874 - gi\|77630874\|ref\|ZP_00793460.1\| COG0452: Phosphopantothenoylcysteine synthetase/decarboxylase [Yersin...	0.0	[1..405]	[1..405]
gi\|22124013, gi\|... - gi\|22124013\|ref\|NP_667436.1\| phosphopantothenoylcysteine synthase/decarboxylase [Yersinia pestis KIM... gi\|145212793, gi... - gi\|145601097\|ref\|YP_001165173.1\| bifunctional phosphopantothenoylcysteine decarboxylase/phosphopanto... gi\|165926067, gi... - gi\|165926067\|ref\|ZP_02221899.1\| phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cyste... gi\|166213762, gi... - gi\|166213762\|ref\|ZP_02239797.1\| phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cyste... gi\|166011425, gi... - gi\|166011425\|ref\|ZP_02232323.1\| phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cyste... gi\|167418905, gi... - gi\|167418905\|ref\|ZP_02310658.1\| phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cyste... gi\|167402115, gi... - gi\|167402115\|ref\|ZP_02307592.1\| phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cyste... gi\|186893391, gi... - gi\|186893391\|ref\|YP_001870503.1\| phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cyst... gi\|89103898 - gi\|89103898\|ref\|ZP_01176458.1\| COG0452: Phosphopantothenoylcysteine synthetase/decarboxylase [Yersin... gi\|167426675, gi... - gi\|167426675\|ref\|ZP_02318428.1\| phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cyste... gi\|108809485, gi... - gi\|108809485\|ref\|YP_653401.1\| bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothe... gi\|77634073, gi\|... - gi\|77634073\|ref\|ZP_00796182.1\| COG0452: Phosphopantothenoylcysteine synthetase/decarboxylase [Yersin... gi\|108813962, gi... - gi\|108813962\|ref\|YP_649729.1\| bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothe...	0.0	[1..405]	[39..443]
gi\|77961978, gi\|... - gi\|77961978\|ref\|ZP_00825805.1\| COG0452: Phosphopantothenoylcysteine synthetase/decarboxylase [Yersin...	0.0	[1..405]	[1..405]
gi\|48868497, gi\|... - gi\|68249541\|ref\|YP_248653.1\| bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothen...	0.0	[4..401]	[2..398]
gi\|37528675, gi\|... - gi\|37528675\|ref\|NP_932020.1\| phosphopantothenoylcysteine synthase/decarboxylase [Photorhabdus lumine...	0.0	[1..404]	[1..404]
COABC_HAEIN - Coenzyme A biosynthesis bifunctional protein CoaBC OS=Haemophilus influenzae (strain ATCC 51907 / DS... DFP_HAEIN, COABC... - (P44953) Coenzyme A biosynthesis bifunctional protein coaBC (DNA/pantothenate metabolism flavoprotei...	0.0	[5..401]	[3..398]
gi\|238722309, gi... - gi\|77972442\|ref\|ZP_00828008.1\| COG0452: Phosphopantothenoylcysteine synthetase/decarboxylase [Yersin...	0.0	[1..405]	[1..405]
gi\|238783987, gi... - gi\|77958459\|ref\|ZP_00822492.1\| COG0452: Phosphopantothenoylcysteine synthetase/decarboxylase [Yersin...	0.0	[1..405]	[1..405]
gi\|170718971, gi... - gi\|32030564\|ref\|ZP_00133390.1\| COG0452: Phosphopantothenoylcysteine synthetase/decarboxylase [Haemop...	0.0	[2..402]	[1..403]
gi\|46129101 - gi\|46129101\|ref\|ZP_00155753.2\| COG0452: Phosphopantothenoylcysteine synthetase/decarboxylase [Haemop...	0.0	[4..401]	[2..398]

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Predicted Domain #1

Region A:
Residues: [1-190]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMTGLSGKHI VLGISGGIAA YKSPELVRRL RDKGADVRVV MTHAAKAFIA PLTLQAVSGY  60
   61 PVSDDLLDPA AEAAMGHIEL GKWADLVIIA PATADLLARM AAGMANDLLT TVCLATAAPI 120
  121 AAVPAMNQQM YRAPATQENL QTLSKWGVLL WGPDSGSQAC GDIGPGRMLD PQEIVALAYN 180
  181 HFSAKQDLQH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	48.045757
Match:	1qzuA
Description:	crystal structure of human phosphopantothenoylcysteine decarboxylase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphopantothenoylcysteine decarboxylase activity	3.86093811191169	bayes_pls_golite062009
phosphopantothenate--cysteine ligase activity	2.64345867885176	bayes_pls_golite062009
carboxy-lyase activity	1.79168084682693	bayes_pls_golite062009
catalytic activity	1.51672397362026	bayes_pls_golite062009
carbon-carbon lyase activity	1.03827559540394	bayes_pls_golite062009
binding	0.299141917010304	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [191-405]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSVMITAGPT REPLDPVRFI SNQSSGKMGF AIAQALAARG SNVTLIAGPV NLSTPEGVKR  60
   61 IDVITALEMQ QAVQKIAQQQ NIFISCAAVA DYRAEHVSDE KIKKQGDEIT LKLVKNPDIV 120
  121 AGVASMAKNR PFVVGFAAET QNVEEYARQK LARKNLDLIC ANDVSLAEHG FNSDTNALHL 180
  181 FWSTGEKRLP LSDKYLLSQR LIDEIVSRYD EKNRH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	71.522879
Match:	1u7uA
Description:	Phosphopantothenoylcysteine synthetase from E. coli
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphopantothenate--cysteine ligase activity	5.69075768451173	bayes_pls_golite062009
phosphopantothenoylcysteine decarboxylase activity	5.47152792211468	bayes_pls_golite062009
catalytic activity	1.32370671504792	bayes_pls_golite062009
carboxy-lyase activity	1.28899846789805	bayes_pls_golite062009
ligase activity	0.615843055306698	bayes_pls_golite062009
carbon-carbon lyase activity	0.53776941010038	bayes_pls_golite062009
acid-amino acid ligase activity	0.529888965129474	bayes_pls_golite062009
binding	0.396515598353762	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	0.133284065682966	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: