YRC Public Data Repository - Protein Structure Prediction

Protein:	DEF_MYCLE
Organism:	Mycobacterium leprae TN
Length:	197 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DEF_MYCLE.

Description	E-value	Query Range	Subject Range
gi\|90195355, gi\|... - gi\|90205918\|ref\|ZP_01208556.1\| Peptide deformylase [Mycobacterium vanbaalenii PYR-1], gi\|90195355\|gb...	265.0	[0..1]	[196..34]
DEF_MYCPA - Peptide deformylase OS=Mycobacterium paratuberculosis GN=def PE=3 SV=1 gi\|254777164 - gi\|254777164\|ref\|ZP_05218680.1\| peptide deformylase [Mycobacterium avium subsp. avium ATCC 25291] DEF_MYCPA - Peptide deformylase OS=Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10) GN=def PE=3 SV=1	262.0	[0..1]	[196..1]
gi\|253318856, gi... - gi\|253797353\|ref\|YP_003030354.1\| polypeptide deformylase def [Mycobacterium tuberculosis KZN 1435], ... gi\|254549376 - gi\|254549376\|ref\|ZP_05139823.1\| peptide deformylase [Mycobacterium tuberculosis '98-R604 INH-RIF-EM'... gi\|254817405 - gi\|254817405\|ref\|ZP_05222406.1\| peptide deformylase [Mycobacterium tuberculosis KZN 4207] gi\|134148907, gi... - gi\|254363393\|ref\|ZP_04979439.1\| polypeptide deformylase def (formylmethionine deformylase) [Mycobact... gi\|255098374 - gi\|255098374\|ref\|ZP_05327852.1\| peptide deformylase [Mycobacterium tuberculosis KZN 605] DEF_MYCTO - Peptide deformylase OS=Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) GN=def PE=3 SV=1 gi\|215429251 - gi\|215429251\|ref\|ZP_03427170.1\| peptide deformylase [Mycobacterium tuberculosis EAS054] gi\|215425650 - gi\|215425650\|ref\|ZP_03423569.1\| peptide deformylase [Mycobacterium tuberculosis T92] gi\|218752062 - gi\|218752062\|ref\|ZP_03530858.1\| peptide deformylase [Mycobacterium tuberculosis GM 1503] DEF_MYCTU - Peptide deformylase OS=Mycobacterium tuberculosis GN=def PE=1 SV=1 DEF_MYCBP - Peptide deformylase OS=Mycobacterium bovis (strain BCG / Pasteur 1173P2) GN=def PE=3 SV=1 gi\|215444525 - gi\|215444525\|ref\|ZP_03431277.1\| peptide deformylase [Mycobacterium tuberculosis T85] DEF_MYCBT - Peptide deformylase OS=Mycobacterium bovis (strain BCG / Tokyo 172 / ATCC 35737 / TMC 1019) GN=def P... gi\|219556250 - gi\|219556250\|ref\|ZP_03535326.1\| peptide deformylase [Mycobacterium tuberculosis T17] DEF_MYCTA - Peptide deformylase OS=Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra) GN=def PE=3 SV=1 gi\|254230779, gi... - gi\|81255735\|ref\|ZP_00880205.1\| COG0242: N-formylmethionyl-tRNA deformylase [Mycobacterium tuberculos... gi\|215409945 - gi\|215409945\|ref\|ZP_03418753.1\| peptide deformylase [Mycobacterium tuberculosis 94_M4241A] gi\|123213975, gi... - gi\|76785713\|ref\|ZP_00772877.1\| COG0242: N-formylmethionyl-tRNA deformylase [Mycobacterium tuberculos... gi\|215402181 - gi\|215402181\|ref\|ZP_03414362.1\| peptide deformylase [Mycobacterium tuberculosis 02_1987] DEF_MYCTU - Peptide deformylase OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) GN=def PE=1 SV=1	259.0	[0..1]	[196..1]
DEF_MYCBO - Peptide deformylase OS=Mycobacterium bovis GN=def PE=3 SV=1 DEF_MYCBO - Peptide deformylase OS=Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) GN=def PE=3 SV=1	258.0	[0..1]	[196..1]
DEF_MYCSJ - Peptide deformylase OS=Mycobacterium sp. (strain JLS) GN=def PE=3 SV=1 DEF_MYCSS - Peptide deformylase OS=Mycobacterium sp. (strain MCS) GN=def PE=3 SV=1 DEF_MYCSK - Peptide deformylase OS=Mycobacterium sp. (strain KMS) GN=def PE=3 SV=1	253.0	[0..1]	[196..1]
DEF_MYCGI - Peptide deformylase OS=Mycobacterium gilvum (strain PYR-GCK) GN=def PE=3 SV=1	252.0	[0..1]	[196..1]
DEF2_CORGL - Peptide deformylase 2 OS=Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG ... DEF2_CORGL - Peptide deformylase 2 OS=Corynebacterium glutamicum GN=def2 PE=3 SV=1	251.0	[0..1]	[196..1]
DEF2_COREF - Peptide deformylase 2 OS=Corynebacterium efficiens GN=def2 PE=3 SV=1 DEF2_COREF - Peptide deformylase 2 OS=Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189...	250.0	[0..1]	[196..1]
gi\|23469370, gi\|... - gi\|66043290\|ref\|YP_233131.1\| peptide deformylase [Pseudomonas syringae pv. syringae B728a], gi\|63253...	245.0	[0..1]	[178..1]
DEF1_PSEPK - Peptide deformylase 1 OS=Pseudomonas putida (strain KT2440) GN=def1 PE=3 SV=1 tr\|E4R9N8\|E4R9N8... - Peptide deformylase OS=Pseudomonas putida (strain BIRD-1) GN=def PE=3 SV=1 gi\|82737338, gi\|... - gi\|82737338\|ref\|ZP_00900188.1\| Formylmethionine deformylase [Pseudomonas putida F1], gi\|82715502\|gb\|... tr\|I7BRK4\|I7BRK4... - Peptide deformylase OS=Pseudomonas putida (strain DOT-T1E) GN=def PE=3 SV=1	244.0	[0..1]	[178..1]

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Predicted Domain #1

Region A:
Residues: [1-197]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAIAPIRIVG DPVLHTPTAP VQVAADGSLP ANLNGLISTM YDTMDAAHGV GLAANQIGYG  60
   61 LRVFVYDCAE DCRQTARRRG VVINPILETS EIPETMPDPD TDNEGCLSVP GESFPIGRAQ 120
  121 WARVTGLDAD GNPVTTEGTG LFARMLQHET GHLDGFLYLD YLIGRHARSA KRAIKSRHWG 180
  181 VPGLSWMPGE VPDPFGP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	65.0
Match:	1n5nA
Description:	Peptide deformylase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	2.58820956037645	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	2.29341894440799	bayes_pls_golite062009
peptide deformylase activity	2.09701270257336	bayes_pls_golite062009
hydrolase activity	1.74603757697733	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	1.59643176725105	bayes_pls_golite062009
formylmethionine deformylase activity	0.90550535791718	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: