YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|26110715, gi\|...
Organism:	Escherichia coli CFT073
Length:	430 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|26110715, gi|....

Description	E-value	Query Range	Subject Range
gi\|91213156, gi\|... - gi\|91213156\|ref\|YP_543142.1\| bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothen... gi\|115515035, gi... - gi\|117625911\|ref\|YP_859234.1\| bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothe... gi\|237703410, gi... - gi\|237703410\|ref\|ZP_04533891.1\| pantothenate metabolism flavoprotein Dfp [Escherichia sp. 3_2_53FAA]...	502.0	[0..1]	[430..1]
gi\|290489 - gi\|290489\|gb\|AAA61992.1\| dfp (CG Site No. 18430)	501.0	[0..1]	[430..1]
gi\|74314127, gi\|... - gi\|74314127\|ref\|YP_312546.1\| flavoprotein affecting synthesis of DNA and pantothenate metabolism [Sh...	501.0	[0..1]	[430..1]
gi\|15978163, gi\|... - gi\|16120401\|ref\|NP_403714.1\| phosphopantothenoylcysteine synthase/decarboxylase [Yersinia pestis CO9... gi\|150260888, gi... - gi\|150260888\|ref\|ZP_01917616.1\| DNA/pantothenate metabolism flavoprotein [Yersinia pestis CA88-4125]... gi\|51594403, gi\|... - gi\|51594403\|ref\|YP_068594.1\| phosphopantothenoylcysteine synthase/decarboxylase [Yersinia pseudotube... Q66GD7\|Q66GD7_YERPS - DNA/pantothenate metabolism flavoprotein - Yersinia pseudotuberculosis gi\|165936230, gi... - gi\|165936230\|ref\|ZP_02224799.1\| phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cyste... gi\|45434769, gi\|... - gi\|45439914\|ref\|NP_991453.1\| phosphopantothenoylcysteine synthase/decarboxylase [Yersinia pestis bio... gi\|25322282 - pir\|\|AI0006 DNA/pantothenate metabolism flavoprotein [imported] - Yersinia pestis (strain CO92)	500.0	[0..23]	[429..1]
gi\|81247413, gi\|... - gi\|82546002\|ref\|YP_409949.1\| Dfp [Shigella boydii Sb227], gi\|81247413\|gb\|ABB68121.1\| Dfp [Shigella b...	500.0	[0..1]	[430..1]
gi\|77630874 - gi\|77630874\|ref\|ZP_00793460.1\| COG0452: Phosphopantothenoylcysteine synthetase/decarboxylase [Yersin...	500.0	[0..23]	[429..1]
gi\|22124013, gi\|... - gi\|22124013\|ref\|NP_667436.1\| phosphopantothenoylcysteine synthase/decarboxylase [Yersinia pestis KIM... gi\|145212793, gi... - gi\|145601097\|ref\|YP_001165173.1\| bifunctional phosphopantothenoylcysteine decarboxylase/phosphopanto... gi\|165926067, gi... - gi\|165926067\|ref\|ZP_02221899.1\| phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cyste... gi\|166213762, gi... - gi\|166213762\|ref\|ZP_02239797.1\| phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cyste... gi\|166011425, gi... - gi\|166011425\|ref\|ZP_02232323.1\| phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cyste... gi\|167418905, gi... - gi\|167418905\|ref\|ZP_02310658.1\| phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cyste... gi\|167402115, gi... - gi\|167402115\|ref\|ZP_02307592.1\| phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cyste... gi\|186893391, gi... - gi\|186893391\|ref\|YP_001870503.1\| phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cyst... gi\|89103898 - gi\|89103898\|ref\|ZP_01176458.1\| COG0452: Phosphopantothenoylcysteine synthetase/decarboxylase [Yersin... gi\|167426675, gi... - gi\|167426675\|ref\|ZP_02318428.1\| phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cyste... gi\|108809485, gi... - gi\|108809485\|ref\|YP_653401.1\| bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothe... gi\|77634073, gi\|... - gi\|77634073\|ref\|ZP_00796182.1\| COG0452: Phosphopantothenoylcysteine synthetase/decarboxylase [Yersin... gi\|108813962, gi... - gi\|108813962\|ref\|YP_649729.1\| bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothe...	499.0	[0..23]	[429..39]
gi\|81243277, gi\|... - gi\|82779129\|ref\|YP_405478.1\| Dfp [Shigella dysenteriae Sd197], gi\|81243277\|gb\|ABB63987.1\| Dfp [Shige...	498.0	[0..1]	[430..1]
gi\|24114908, gi\|... - gi\|24114908\|ref\|NP_709418.1\| phosphopantothenoylcysteine synthase/decarboxylase [Shigella flexneri 2...	498.0	[0..1]	[430..1]
gi\|170718971, gi... - gi\|32030564\|ref\|ZP_00133390.1\| COG0452: Phosphopantothenoylcysteine synthetase/decarboxylase [Haemop...	490.0	[0..24]	[427..1]

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Predicted Domain #1

Region A:
Residues: [1-210]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKARQQKYCD KIANFWCHPT GKIIMSLAGK KIVLGVSGGI AAYKTPELVR RLRDRGADVR  60
   61 VAMTEAAKAF ITPLSLQAVS GYPVSDSLLD PAAEAAMGHI ELGKWADLVI LAPATADLIA 120
  121 RVAAGMANDL VSTICLATPA PVAVLPAMNQ QMYRAAATQH NLEVLASRGL LIWGPDSGSQ 180
  181 ACGDIGPGRM LDPLTIVDMA VAHFSPVNDL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	42.0
Match:	1qzuA
Description:	crystal structure of human phosphopantothenoylcysteine decarboxylase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphopantothenoylcysteine decarboxylase activity	4.02491392416271	bayes_pls_golite062009
phosphopantothenate--cysteine ligase activity	2.79577339932291	bayes_pls_golite062009
3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity	2.57411029854435	bayes_pls_golite062009
carboxy-lyase activity	2.27469953971238	bayes_pls_golite062009
catalytic activity	1.88716391063227	bayes_pls_golite062009
carbon-carbon lyase activity	1.67751595868044	bayes_pls_golite062009
lyase activity	0.646446561158526	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [211-430]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KHLNIMITAG PTREPLDPVR YISNHSSGKM GFAIAAAAAR RGANVTLVSG PVSLPTPPFV  60
   61 KRVDVMTALE MEAAVNASVQ QQNIFIGCAA VADYRAATVA PEKIKKQATQ GDELTIKMVK 120
  121 NPDIVAGVAA LKDHRPYVVG FAAETNNVEE YARQKRIRKN LDLICANDVS QPTQGFNSDN 180
  181 NALHLFWQDG DKVLPLERKE LLGQLLLDEI VTRYDEKNRR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	76.045757
Match:	1u7uA
Description:	Phosphopantothenoylcysteine synthetase from E. coli
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphopantothenate--cysteine ligase activity	5.84307240498288	bayes_pls_golite062009
phosphopantothenoylcysteine decarboxylase activity	5.6355037343657	bayes_pls_golite062009
carboxy-lyase activity	1.7720171607835	bayes_pls_golite062009
catalytic activity	1.69414665205993	bayes_pls_golite062009
carbon-carbon lyase activity	1.17700977337688	bayes_pls_golite062009
ligase activity	0.75488703247662	bayes_pls_golite062009
acid-amino acid ligase activity	0.507933091040939	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	0.357333622343651	bayes_pls_golite062009
lyase activity	0.155748822211036	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: