YRC Public Data Repository - Protein Structure Prediction

Protein:	DCUP_SALTI
Organism:	Salmonella enterica subsp. enterica serovar Typhi
Length:	354 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DCUP_SALTI.

Description	E-value	Query Range	Subject Range
DCUP_PSEA6 - Uroporphyrinogen decarboxylase OS=Pseudoalteromonas atlantica (strain T6c / ATCC BAA-1087) GN=hemE P...	0.0	[1..353]	[1..353]
DCUP_SALPB - Uroporphyrinogen decarboxylase OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=hemE PE=3 ... DCUP_SALCH - Uroporphyrinogen decarboxylase OS=Salmonella choleraesuis GN=hemE PE=3 SV=1 DCUP_SALCH - Uroporphyrinogen decarboxylase OS=Salmonella choleraesuis GN=hemE PE=3 SV=1 DCUP_SALPB - Uroporphyrinogen decarboxylase OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=hemE PE=3 ... DCUP_SALPC - Uroporphyrinogen decarboxylase OS=Salmonella paratyphi C (strain RKS4594) GN=hemE PE=3 SV=1 lcl\|NC_016856.1_... - [gene=hemE] [protein=uroporphyrinogen decarboxylase] [protein_id=YP_005240449.1] [location=4397726..... DCUP_SALCH - Uroporphyrinogen decarboxylase OS=Salmonella choleraesuis (strain SC-B67) GN=hemE PE=3 SV=1 gi\|168467901, gi... - gi\|195629023\|gb\|EDX48415.1\| uroporphyrinogen decarboxylase [Salmonella enterica subsp. enterica sero... gi\|167994968, gi... - gi\|205327252\|gb\|EDZ14016.1\| uroporphyrinogen decarboxylase [Salmonella enterica subsp. enterica sero... gi\|167553829, gi... - gi\|205321826\|gb\|EDZ09665.1\| uroporphyrinogen decarboxylase [Salmonella enterica subsp. enterica sero...	0.0	[1..354]	[1..354]
DCUP_ECOL6 - Uroporphyrinogen decarboxylase OS=Escherichia coli O6 GN=hemE PE=3 SV=1 DCUP_ECOL6 - Uroporphyrinogen decarboxylase OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=hem... gi\|227837547, gi... - gi\|227885473\|ref\|ZP_04003278.1\| uroporphyrinogen decarboxylase [Escherichia coli 83972], gi\|22783754... sp\|B7UPF2\|DCUP_ECO27 - Uroporphyrinogen decarboxylase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=hemE PE=3 SV=... DCUP_ECOK1 - Uroporphyrinogen decarboxylase OS=Escherichia coli O1:K1 / APEC GN=hemE PE=3 SV=1 gi\|226903077, gi... - gi\|237702764\|ref\|ZP_04533245.1\| uroporphyrinogen decarboxylase [Escherichia sp. 3_2_53FAA], gi\|22690... DCUP_ECO27 - Uroporphyrinogen decarboxylase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=hemE PE=3 SV=... DCUP_ECO45 - Uroporphyrinogen decarboxylase OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=hemE PE=3 SV=1 DCUP_ECOUT - Uroporphyrinogen decarboxylase OS=Escherichia coli (strain UTI89 / UPEC) GN=hemE PE=3 SV=1	0.0	[1..353]	[1..353]
EG11543 - uroporphyrinogen decarboxylase / Uroporphyrinogen decarboxylase DCUP_ECOBW - Uroporphyrinogen decarboxylase OS=Escherichia coli (strain K12 / MC4100 / BW2952) GN=hemE PE=3 SV=1 gi\|251787255, gi... - gi\|251787255\|ref\|YP_003001559.1\| hypothetical protein B21_03827 [Escherichia coli BL21], gi\|24237952... gi\|254290689, gi... - gi\|254290689\|ref\|YP_003056437.1\| uroporphyrinogen decarboxylase [Escherichia coli BL21(DE3)], gi\|253... DCUP_ECOSM - Uroporphyrinogen decarboxylase OS=Escherichia coli (strain SMS-3-5 / SECEC) GN=hemE PE=3 SV=1 gi\|254039254, gi... - gi\|254039254\|ref\|ZP_04873303.1\| uroporphyrinogen decarboxylase [Escherichia sp. 1_1_43], gi\|22683848... DCUP_ECODH - Uroporphyrinogen decarboxylase OS=Escherichia coli (strain K12 / DH10B) GN=hemE PE=3 SV=1 gi\|254163939, gi... - gi\|254163939\|ref\|YP_003047047.1\| uroporphyrinogen decarboxylase [Escherichia coli B str. REL606], gi... DCUP_ECOLC - Uroporphyrinogen decarboxylase OS=Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks) GN=hemE PE... gi\|83584827, gi\|... - gi\|83584827\|ref\|ZP_00923487.1\| COG0407: Uroporphyrinogen-III decarboxylase [Escherichia coli 101-1],... DCUP_SHISS - Uroporphyrinogen decarboxylase OS=Shigella sonnei (strain Ss046) GN=hemE PE=3 SV=1 gi\|85676072, gi\|... - gi\|89110041\|ref\|AP_003821.1\| uroporphyrinogen decarboxylase [Escherichia coli str. K-12 substr. W311... EG11543 - uroporphyrinogen decarboxylase / Uroporphyrinogen decarboxylase DCUP_ECOLI - Uroporphyrinogen decarboxylase (EC 4.1.1.37) (URO-D) (UPD) - Escherichia coli DCUP_ECOHS - Uroporphyrinogen decarboxylase OS=Escherichia coli O9:H4 (strain HS) GN=hemE PE=3 SV=1 DCUP_ECO8A - Uroporphyrinogen decarboxylase OS=Escherichia coli O8 (strain IAI1) GN=hemE PE=3 SV=1 gi\|194429956, gi... - gi\|75208795\|ref\|ZP_00709081.1\| COG0407: Uroporphyrinogen-III decarboxylase [Escherichia coli B171], ... DCUP_ECOSE - Uroporphyrinogen decarboxylase OS=Escherichia coli (strain SE11) GN=hemE PE=3 SV=1 DCUP_SHIB3 - Uroporphyrinogen decarboxylase OS=Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) GN=hemE P... DCUP_ECO24 - Uroporphyrinogen decarboxylase OS=Escherichia coli O139:H28 (strain E24377A / ETEC) GN=hemE PE=3 SV=... DCUP_ECOLU - Uroporphyrinogen decarboxylase OS=Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC) GN=hemE PE=3 ... gi\|192925942, gi... - gi\|75255494\|ref\|ZP_00727293.1\| COG0407: Uroporphyrinogen-III decarboxylase [Escherichia coli E22], g... gi\|188486933, gi... - gi\|75514764\|ref\|ZP_00736993.1\| COG0407: Uroporphyrinogen-III decarboxylase [Escherichia coli 53638],... gi\|75228132, gi\|... - gi\|75228132\|ref\|ZP_00714801.1\| COG0407: Uroporphyrinogen-III decarboxylase [Escherichia coli B7A], g... gi\|193067936, gi... - gi\|75238538\|ref\|ZP_00722527.1\| COG0407: Uroporphyrinogen-III decarboxylase [Escherichia coli E110019... gi\|124498597, gi... - gi\|124531383\|ref\|ZP_01701693.1\| uroporphyrinogen decarboxylase [Escherichia coli B], gi\|124498597\|gb...	0.0	[1..353]	[1..353]
gi\|189001799, gi... - gi\|189001799\|gb\|EDU70785.1\| uroporphyrinogen decarboxylase [Escherichia coli O157:H7 str. EC4076], g... DCUP_ECO57 - Uroporphyrinogen decarboxylase OS=Escherichia coli O157:H7 GN=hemE PE=3 SV=1 gi\|168777390, gi... - gi\|187767364\|gb\|EDU31208.1\| uroporphyrinogen decarboxylase [Escherichia coli O157:H7 str. EC4196], g... gi\|254595395, gi... - gi\|254795995\|ref\|YP_003080832.1\| uroporphyrinogen decarboxylase [Escherichia coli O157:H7 str. TW143... gi\|189379217, gi... - gi\|189379217\|gb\|EDU97633.1\| uroporphyrinogen decarboxylase [Escherichia coli O157:H7 str. EC508], gi... gi\|168790357, gi... - gi\|189370169\|gb\|EDU88585.1\| uroporphyrinogen decarboxylase [Escherichia coli O157:H7 str. EC869], gi... gi\|168758607, gi... - gi\|189354597\|gb\|EDU73016.1\| uroporphyrinogen decarboxylase [Escherichia coli O157:H7 str. EC4401], g... gi\|188014036, gi... - gi\|188014036\|gb\|EDU52158.1\| uroporphyrinogen decarboxylase [Escherichia coli O157:H7 str. EC4113], g... gi\|168771469, gi... - gi\|189359758\|gb\|EDU78177.1\| uroporphyrinogen decarboxylase [Escherichia coli O157:H7 str. EC4486], g... gi\|168764577, gi... - gi\|189365451\|gb\|EDU83867.1\| uroporphyrinogen decarboxylase [Escherichia coli O157:H7 str. EC4501], g... gi\|209751708, gi... - pir\|\|H91243 uroporphyrinogen decarboxylase [imported] - Escherichia coli (strain O157:H7, substrain ... gi\|217326346, gi... - gi\|217326346\|ref\|ZP_03442430.1\| uroporphyrinogen decarboxylase [Escherichia coli O157:H7 str. TW1458... DCUP_ECO5E - Uroporphyrinogen decarboxylase OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=hemE PE=3 SV=1 gi\|208728531, gi... - gi\|208808730\|ref\|ZP_03251067.1\| uroporphyrinogen decarboxylase [Escherichia coli O157:H7 str. EC4206... gi\|195939623 - gi\|195939623\|ref\|ZP_03085005.1\| uroporphyrinogen decarboxylase [Escherichia coli O157:H7 str. EC4024... gi\|15834174, gi\|... - gi\|15834174\|ref\|NP_312947.1\| uroporphyrinogen decarboxylase [Escherichia coli O157:H7 str. Sakai], g... gi\|208818935, gi... - gi\|208818935\|ref\|ZP_03259255.1\| uroporphyrinogen decarboxylase [Escherichia coli O157:H7 str. EC4042... gi\|208813578, gi... - gi\|208813578\|ref\|ZP_03254907.1\| uroporphyrinogen decarboxylase [Escherichia coli O157:H7 str. EC4045...	0.0	[1..353]	[1..353]
DCUP_VIBVY - Uroporphyrinogen decarboxylase OS=Vibrio vulnificus (strain YJ016) GN=hemE PE=3 SV=1 DCUP_VIBVU - Uroporphyrinogen decarboxylase OS=Vibrio vulnificus GN=hemE PE=3 SV=1 DCUP_VIBVU - Uroporphyrinogen decarboxylase OS=Vibrio vulnificus (strain CMCP6) GN=hemE PE=3 SV=1	0.0	[1..353]	[1..354]
DCUP_SALTY - Uroporphyrinogen decarboxylase OS=Salmonella typhimurium GN=hemE PE=3 SV=1 DCUP_SALTY - Uroporphyrinogen decarboxylase OS=Salmonella typhimurium GN=hemE PE=3 SV=1 DCUP_SALTY - Uroporphyrinogen decarboxylase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=he...	0.0	[1..354]	[1..354]
DCUP_SHIDS - Uroporphyrinogen decarboxylase OS=Shigella dysenteriae serotype 1 (strain Sd197) GN=hemE PE=3 SV=1	0.0	[1..353]	[1..353]
DCUP_SALPA - Uroporphyrinogen decarboxylase OS=Salmonella paratyphi A GN=hemE PE=3 SV=1 gi\|238913745 - gi\|238913745\|ref\|ZP_04657582.1\| uroporphyrinogen decarboxylase [Salmonella enterica subsp. enterica ... gi\|204931282, gi... - gi\|204931282\|ref\|ZP_03222042.1\| uroporphyrinogen decarboxylase [Salmonella enterica subsp. enterica ... DCUP_SALPA - Uroporphyrinogen decarboxylase OS=Salmonella paratyphi A (strain ATCC 9150 / SARB42) GN=hemE PE=3 SV... DCUP_SALPK - Uroporphyrinogen decarboxylase OS=Salmonella paratyphi A (strain AKU_12601) GN=hemE PE=3 SV=1	0.0	[1..354]	[1..354]
DCUP_SHIFL - Uroporphyrinogen decarboxylase OS=Shigella flexneri GN=hemE PE=1 SV=1 gi\|24115281, gi\|... - gi\|24115281\|ref\|NP_709791.1\| uroporphyrinogen decarboxylase [Shigella flexneri 2a str. 301], gi\|2405... gi\|30064721, gi\|... - gi\|30064721\|ref\|NP_838892.1\| uroporphyrinogen decarboxylase [Shigella flexneri 2a str. 2457T], gi\|30... DCUP_SHIF8 - Uroporphyrinogen decarboxylase OS=Shigella flexneri serotype 5b (strain 8401) GN=hemE PE=3 SV=1	0.0	[1..353]	[1..353]

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Predicted Domain #1

Region A:
Residues: [1-354]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTELKNDRYL RALLRQPVDV TPVWMMRQAG RYLPEYKATR AQAGDFMSLC KNAELACEVT  60
   61 LQPLRRYPLD AAILFSDILT IPDAMGLGLY FEAGEGPRFT APVTCKADVD KLPIPDPEDE 120
  121 LGYVMNAVRT IRRELKGEVP LIGFSGSPWT LATYMVEGGS SKAFTVIKKM MYADPQALHL 180
  181 LLDKLAKSVT LYLNAQIKAG AQSVMIFDTW GGVLTGRDYQ QFSLYYMHKI VDGLLRENDG 240
  241 RRVPVTLFTK GGGQWLEAMA ETGCDALGLD WTTDIADARR RVGHKVALQG NMDPSMLYAP 300
  301 PARIEDEVAT ILAGFGQGEG HVFNLGHGIH QDVPPEHAGA FVEAVHRLSA QYHN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	123.0
Match:	1r3qA
Description:	Uroporphyrinogen Decarboxylase in complex with coproporphyrinogen-I
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
uroporphyrinogen decarboxylase activity	4.48282084722609	bayes_pls_golite062009
catalytic activity	2.37862248560593	bayes_pls_golite062009
carboxy-lyase activity	1.67493268854029	bayes_pls_golite062009
carbon-carbon lyase activity	1.54242506764415	bayes_pls_golite062009
binding	1.19577203030346	bayes_pls_golite062009
transferase activity	1.11861612545715	bayes_pls_golite062009
protein binding	0.30230496242508	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: