YRC Public Data Repository - Protein Structure Prediction

Protein:	RPPH_SALTY
Organism:	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
Length:	176 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RPPH_SALTY.

Description	E-value	Query Range	Subject Range
gi\|189354947, gi... - gi\|189354947\|gb\|EDU73366.1\| (Di)nucleoside polyphosphate hydrolase [Escherichia coli O157:H7 str. EC... gi\|188014869, gi... - gi\|188014869\|gb\|EDU52991.1\| (Di)nucleoside polyphosphate hydrolase [Escherichia coli O157:H7 str. EC... gi\|168766802, gi... - gi\|189363828\|gb\|EDU82247.1\| (Di)nucleoside polyphosphate hydrolase [Escherichia coli O157:H7 str. EC... gi\|189365390, gi... - gi\|189365390\|gb\|EDU83806.1\| (Di)nucleoside polyphosphate hydrolase [Escherichia coli O157:H7 str. EC... gi\|189372212, gi... - gi\|189372212\|gb\|EDU90628.1\| (Di)nucleoside polyphosphate hydrolase [Escherichia coli O157:H7 str. EC... gi\|168778823, gi... - gi\|189003470\|gb\|EDU72456.1\| (Di)nucleoside polyphosphate hydrolase [Escherichia coli O157:H7 str. EC... RPPH_ECOSM - RNA pyrophosphohydrolase OS=Escherichia coli (strain SMS-3-5 / SECEC) GN=rppH PE=3 SV=1 RPPH_ECODH - RNA pyrophosphohydrolase OS=Escherichia coli (strain K12 / DH10B) GN=rppH PE=3 SV=1 RPPH_ECO8A - RNA pyrophosphohydrolase OS=Escherichia coli O8 (strain IAI1) GN=rppH PE=3 SV=1 gi\|217327128, gi... - gi\|217327128\|ref\|ZP_03443211.1\| (Di)nucleoside polyphosphate hydrolase [Escherichia coli O157:H7 str... RPPH_ECO81 - RNA pyrophosphohydrolase OS=Escherichia coli O81 (strain ED1a) GN=rppH PE=3 SV=1 RPPH_ECO45 - RNA pyrophosphohydrolase OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=rppH PE=3 SV=1 RPPH_ECO7I - RNA pyrophosphohydrolase OS=Escherichia coli O7:K1 (strain IAI39 / ExPEC) GN=rppH PE=3 SV=1 RPPH_ECO55 - RNA pyrophosphohydrolase OS=Escherichia coli (strain 55989 / EAEC) GN=rppH PE=3 SV=1 RPPH_ECOLU - RNA pyrophosphohydrolase OS=Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC) GN=rppH PE=3 SV=1 gi\|195936432 - gi\|195936432\|ref\|ZP_03081814.1\| dinucleoside polyphosphate hydrolase [Escherichia coli O157:H7 str. ... gi\|188488921, gi... - gi\|188493722\|ref\|ZP_03000992.1\| (Di)nucleoside polyphosphate hydrolase [Escherichia coli 53638], gi\|... gi\|208734601, gi... - gi\|208813324\|ref\|ZP_03254653.1\| (Di)nucleoside polyphosphate hydrolase [Escherichia coli O157:H7 str... gi\|208727099, gi... - gi\|208807298\|ref\|ZP_03249635.1\| (Di)nucleoside polyphosphate hydrolase [Escherichia coli O157:H7 str... RPPH_ECO5E - RNA pyrophosphohydrolase OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=rppH PE=3 SV=1 gi\|208741442, gi... - gi\|208821319\|ref\|ZP_03261639.1\| (Di)nucleoside polyphosphate hydrolase [Escherichia coli O157:H7 str... RPPH_ECO27 - RNA pyrophosphohydrolase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=rppH PE=3 SV=1 RPPH_ECOSE - RNA pyrophosphohydrolase OS=Escherichia coli (strain SE11) GN=rppH PE=3 SV=1 gi\|12517315, gi\|... - gi\|15803349\|ref\|NP_289382.1\| dinucleoside polyphosphate hydrolase [Escherichia coli O157:H7 EDL933],... gi\|253772316, gi... - gi\|254289517\|ref\|YP_003055265.1\| dinucleoside polyphosphate hydrolase [Escherichia coli BL21(DE3)], ... EG13091 - RNA pyrophosphohydrolase / RNA pyrophosphohydrolase, destabilizes primary transcripts gi\|226839505, gi... - gi\|254037881\|ref\|ZP_04871939.1\| dinucleoside polyphosphate hydrolase [Escherichia sp. 1_1_43], gi\|22... gi\|254162758, gi... - gi\|254162758\|ref\|YP_003045866.1\| dinucleoside polyphosphate hydrolase [Escherichia coli B str. REL60... gi\|254794768, gi... - gi\|254794768\|ref\|YP_003079605.1\| nucleotide hydrolase [Escherichia coli O157:H7 str. TW14359], gi\|25... NUDH_ECOL6, RPPH... - RNA pyrophosphohydrolase OS=Escherichia coli O6 GN=rppH PE=3 SV=1, (Di)nucleoside polyphosphate hydr... EG13091 - RNA pyrophosphohydrolase / RNA pyrophosphohydrolase, destabilizes primary transcripts NUDH_ECOLI - (Di)nucleoside polyphosphate hydrolase (EC 3.6.1.-) (Ap5A pyrophosphatase) - Escherichia coli sp\|B7UHP7\|RPPH_ECO27 - RNA pyrophosphohydrolase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=rppH PE=3 SV=1 RPPH_ECOLC - RNA pyrophosphohydrolase OS=Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks) GN=rppH PE=3 SV=... RPPH_SHIFL - RNA pyrophosphohydrolase OS=Shigella flexneri GN=rppH PE=3 SV=1 RPPH_ECOL6 - RNA pyrophosphohydrolase OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=rppH PE=3... gi\|24114109, gi\|... - gi\|24114109\|ref\|NP_708619.1\| dinucleoside polyphosphate hydrolase [Shigella flexneri 2a str. 301], g... RPPH_ECO57 - RNA pyrophosphohydrolase OS=Escherichia coli O157:H7 GN=rppH PE=3 SV=1 gi\|30064171, gi\|... - gi\|30064171\|ref\|NP_838342.1\| dinucleoside polyphosphate hydrolase [Shigella flexneri 2a str. 2457T],... RPPH_ECOUT - RNA pyrophosphohydrolase OS=Escherichia coli (strain UTI89 / UPEC) GN=rppH PE=3 SV=1 RPPH_SHIDS - RNA pyrophosphohydrolase OS=Shigella dysenteriae serotype 1 (strain Sd197) GN=rppH PE=3 SV=1 gi\|85675646, gi\|... - gi\|89109613\|ref\|AP_003393.1\| nucleotide hydrolase [Escherichia coli str. K-12 substr. W3110], gi\|856... gi\|13363159, gi\|... - gi\|15832941\|ref\|NP_311714.1\| dinucleoside polyphosphate hydrolase [Escherichia coli O157:H7 str. Sak... RPPH_ECOL5 - RNA pyrophosphohydrolase OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=rppH PE=3 SV=1 RPPH_SHIF8 - RNA pyrophosphohydrolase OS=Shigella flexneri serotype 5b (strain 8401) GN=rppH PE=3 SV=1 gi\|83584787 - gi\|83584787\|ref\|ZP_00923449.1\| COG0494: NTP pyrophosphohydrolases including oxidative damage repair ... RPPH_ECO24 - RNA pyrophosphohydrolase OS=Escherichia coli O139:H28 (strain E24377A / ETEC) GN=rppH PE=3 SV=1 RPPH_ECOHS - RNA pyrophosphohydrolase OS=Escherichia coli O9:H4 (strain HS) GN=rppH PE=3 SV=1 gi\|194426273, gi... - gi\|75212537\|ref\|ZP_00712561.1\| COG0494: NTP pyrophosphohydrolases including oxidative damage repair ... gi\|193071414, gi... - gi\|75215028\|ref\|ZP_00713488.1\| COG0494: NTP pyrophosphohydrolases including oxidative damage repair ... gi\|190901343, gi... - gi\|75228180\|ref\|ZP_00714842.1\| COG0494: NTP pyrophosphohydrolases including oxidative damage repair ... gi\|75241761, gi\|... - gi\|75241761\|ref\|ZP_00725580.1\| COG0494: NTP pyrophosphohydrolases including oxidative damage repair ... gi\|193065100, gi... - gi\|75256818\|ref\|ZP_00728412.1\| COG0494: NTP pyrophosphohydrolases including oxidative damage repair ... gi\|124500317, gi... - gi\|124528789\|ref\|ZP_01700013.1\| NUDIX hydrolase [Escherichia coli B], gi\|124500317\|gb\|EAY47792.1\| NU... gi\|227888394, gi... - gi\|227888394\|ref\|ZP_04006199.1\| dinucleoside polyphosphate hydrolase [Escherichia coli 83972], gi\|22... RPPH_ECOBW - RNA pyrophosphohydrolase OS=Escherichia coli (strain K12 / MC4100 / BW2952) GN=rppH PE=3 SV=1 gi\|83569176 - gi\|83569176\|ref\|ZP_00920634.1\| COG0494: NTP pyrophosphohydrolases including oxidative damage repair ... gi\|242378378, gi... - gi\|251786105\|ref\|YP_003000409.1\| hypothetical protein B21_02639 [Escherichia coli BL21], gi\|24237837...	8.0E-41	[1..176]	[1..176]
RPPH_SHISS - RNA pyrophosphohydrolase OS=Shigella sonnei (strain Ss046) GN=rppH PE=3 SV=1 RPPH_SHIB3 - RNA pyrophosphohydrolase OS=Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) GN=rppH PE=3 SV...	1.0E-40	[1..176]	[1..176]
RPPH_SHIBS - RNA pyrophosphohydrolase OS=Shigella boydii serotype 4 (strain Sb227) GN=rppH PE=3 SV=1	1.0E-39	[1..176]	[1..176]
RPPH_PHOLL - RNA pyrophosphohydrolase OS=Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105565... RPPH_PHOLL, NUDH... - RNA pyrophosphohydrolase OS=Photorhabdus luminescens subsp. laumondii GN=rppH PE=3 SV=1, Probable - ...	2.0E-38	[1..175]	[1..175]
gi\|46129134 - gi\|46129134\|ref\|ZP_00202010.1\| COG0494: NTP pyrophosphohydrolases including oxidative damage repair ... RPPH_HAEIE - RNA pyrophosphohydrolase OS=Haemophilus influenzae (strain PittEE) GN=rppH PE=3 SV=1 gi\|229845953, gi... - gi\|229845953\|ref\|ZP_04466065.1\| dinucleoside polyphosphate hydrolase [Haemophilus influenzae 7P49H1]...	3.0E-38	[1..173]	[1..179]
RPPH_HAEI8 - RNA pyrophosphohydrolase OS=Haemophilus influenzae (strain 86-028NP) GN=rppH PE=3 SV=1	4.0E-38	[1..158]	[1..158]
gi\|238787268, gi... - gi\|77974547\|ref\|ZP_00830087.1\| COG0494: NTP pyrophosphohydrolases including oxidative damage repair ...	4.0E-38	[1..176]	[1..175]
gi\|229813037, gi... - gi\|229844043\|ref\|ZP_04464184.1\| dinucleoside polyphosphate hydrolase [Haemophilus influenzae 6P18H1]... gi\|42631225 - gi\|42631225\|ref\|ZP_00156763.1\| COG0494: NTP pyrophosphohydrolases including oxidative damage repair ... gi\|145641911, gi... - gi\|145641911\|ref\|ZP_01797485.1\| dinucleoside polyphosphate hydrolase [Haemophilus influenzae R3021],... gi\|145641911 - gi\|145641911\|ref\|ZP_01797485.1\| dinucleoside polyphosphate hydrolase [Haemophilus influenzae R3021] gi\|145636968, gi... - gi\|145636968\|ref\|ZP_01792632.1\| dinucleoside polyphosphate hydrolase [Haemophilus influenzae PittHH]... gi\|145634069, gi... - gi\|145634069\|ref\|ZP_01789780.1\| dinucleoside polyphosphate hydrolase [Haemophilus influenzae PittAA]... gi\|145632279, gi... - gi\|145632279\|ref\|ZP_01788014.1\| dinucleoside polyphosphate hydrolase [Haemophilus influenzae 3655], ...	7.0E-38	[1..158]	[1..158]
gi\|238727894, gi... - gi\|77978949\|ref\|ZP_00834372.1\| COG0494: NTP pyrophosphohydrolases including oxidative damage repair ...	7.0E-38	[1..176]	[1..175]
RPPH_HAEIN - RNA pyrophosphohydrolase OS=Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) GN=rp... RPPH_HAEIN, NUDH... - RNA pyrophosphohydrolase OS=Haemophilus influenzae GN=rppH PE=3 SV=2, Probable - Haemophilus influen...	7.0E-38	[1..158]	[1..158]

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Predicted Domain #1

Region A:
Residues: [1-176]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIDDDGYRPN VGIVICNRQG QVMWARRFGQ HSWQFPQGGI NPGESAEQAM YRELFEEVGL  60
   61 SRKDVRILAS TRNWLRYKLP KRLVRWDTKP VCIGQKQKWF LLQLMSADAE INMQTSSTPE 120
  121 FDGWRWVSYW YPVRQVVSFK RDVYRRVMKE FASVVMALQD NPPKLQSAPA YRRKRG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	26.69897
Match:	1f3yA
Description:	Diadenosine tetraphosphate hydrolase (Ap4A hydrolase)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
hydrolase activity	1.86826130963189	bayes_pls_golite062009
catalytic activity	1.86119802438676	bayes_pls_golite062009
RNA pyrophosphohydrolase activity	0.681788425915311	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.544115189438	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.54377405132398	bayes_pls_golite062009
nucleic acid binding	0.468153646537656	bayes_pls_golite062009
binding	0.0581982566440131	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: