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View Structure Prediction Details

Protein: gi|16761135
Organism: Salmonella enterica subsp. enterica serovar Typhi str. CT18
Length: 222 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|16761135.

Description E-value Query
Range		 Subject
Range
gi|75702476, gi|... - gi|75908751|ref|YP_323047.1| GTP cyclohydrolase I [Anabaena variabilis ATCC 29413], gi|75702476|gb|A...
 9.0E-90 [1..222] [17..232]
GCH1_NOSP7 - GTP cyclohydrolase 1 OS=Nostoc punctiforme (strain ATCC 29133 / PCC 73102) GN=folE PE=3 SV=1
 2.0E-89 [1..222] [17..232]
gi|25290301 - pir||AG2466 GTP cyclohydrolase I [imported] - Nostoc sp. (strain PCC 7120)
GCH11_NOSS1 - GTP cyclohydrolase 1 1 OS=Nostoc sp. (strain PCC 7120 / UTEX 2576) GN=folE1 PE=3 SV=1
 5.0E-89 [1..222] [17..232]
gi|46118361, gi|... - gi|67925134|ref|ZP_00518508.1| GTP cyclohydrolase I [Crocosphaera watsonii WH 8501], gi|67853028|gb|...
 3.0E-88 [2..222] [22..238]
GCH1_SYNY3 - GTP cyclohydrolase 1 OS=Synechocystis sp. (strain ATCC 27184 / PCC 6803 / N-1) GN=folE PE=3 SV=1
GCH1_SYNY3 - GTP cyclohydrolase 1 OS=Synechocystis sp. (strain PCC 6803 / Kazusa) GN=folE PE=3 SV=1
gi|7435993 - pir||S76560 GTP cyclohydrolase I (EC 3.5.4.16) - Synechocystis sp. (strain PCC 6803)
 1.0E-87 [3..222] [17..231]
GCH1_SYNEL - GTP cyclohydrolase 1 OS=Synechococcus elongatus GN=folE PE=3 SV=1
GCH1_THEEB - GTP cyclohydrolase 1 OS=Thermosynechococcus elongatus (strain BP-1) GN=folE PE=3 SV=1
 1.0E-86 [3..222] [14..227]
GCH1_SYNE7 - GTP cyclohydrolase 1 OS=Synechococcus elongatus (strain PCC 7942) GN=folE PE=3 SV=2
GCH1_SYNP6 - GTP cyclohydrolase 1 OS=Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) GN=folE PE=3 ...
 2.0E-84 [21..222] [9..209]
gi|22002492 - gi|22002492|gb|AAM82644.1| Gch1 [Synechococcus sp. PCC 7942]
 2.0E-84 [21..222] [15..215]
GCH1_SALCH - GTP cyclohydrolase 1 OS=Salmonella choleraesuis (strain SC-B67) GN=folE PE=3 SV=1
GCH1_SALCH - GTP cyclohydrolase 1 OS=Salmonella choleraesuis GN=folE PE=3 SV=1
GCH1_SALCH - GTP cyclohydrolase 1 OS=Salmonella choleraesuis GN=folE PE=3 SV=1
 7.0E-84 [1..222] [1..222]

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Predicted Domain #1
Region A:
Residues: [1-222] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPSLSKEAAL VHDALVARGL ETPLRPPMDE LDNETRKSLI AGHMTEIMQL LNLDLSDDSL  60
   61 METPHRIAKM YVDEIFAGLD YANFPKITLI ENKMKVDEMV TVRDITLTST CEHHFVTIDG 120
  121 KATVAYIPKD SVIGLSKINR IVQFFAQRPQ VQERLTQQIL TALQTLLGTN NVAVSIDAVH 180
  181 YCVKARGIRD ATSATTTTSL GGLFKSSQNT RQEFLRAVRH HP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 82.39794
Match: 1fbxA
Description: GTP cyclohydrolase I
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
GTP cyclohydrolase I activity 4.1430878480831 bayes_pls_golite062009
cyclohydrolase activity 3.66553359909123 bayes_pls_golite062009
GTP cyclohydrolase activity 3.44912994722205 bayes_pls_golite062009
catalytic activity 2.20788162511962 bayes_pls_golite062009
dihydroneopterin aldolase activity 1.96466418682643 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 1.73101699306211 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.974891318710762 bayes_pls_golite062009
binding 0.392476729829125 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle