YRC Public Data Repository - Protein Structure Prediction

Protein:	HISX_ECOLI
Organism:	Escherichia coli
Length:	434 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HISX_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|190909565, gi... - gi\|191170049\|ref\|ZP_03031603.1\| histidinol dehydrogenase [Escherichia coli F11], gi\|190909565\|gb\|EDV... HISX_ECOL6 - Histidinol dehydrogenase OS=Escherichia coli O6 GN=hisD PE=3 SV=3 gi\|110642233, gi... - gi\|110642233\|ref\|YP_669963.1\| histidinol dehydrogenase [Escherichia coli 536], gi\|110343825\|gb\|ABG70... HISX_ECOL6 - Histidinol dehydrogenase OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=hisD PE=3...	651.0	[0..1]	[434..1]
HISX_SHISS - Histidinol dehydrogenase OS=Shigella sonnei (strain Ss046) GN=hisD PE=3 SV=1	650.0	[0..1]	[434..1]
HIS8_PHOLL - Putative histidine biosynthesis bifunctional protein HisCD OS=Photorhabdus luminescens subsp. laumon... HIS8_PHOLL - Putative histidine biosynthesis bifunctional protein hisCD OS=Photorhabdus luminescens subsp. laumon...	650.0	[0..3]	[431..5]
gi\|26248395, gi\|... - gi\|26248395\|ref\|NP_754435.1\| histidinol dehydrogenase [Escherichia coli CFT073], gi\|26108799\|gb\|AAN8... gi\|91211306, gi\|... - gi\|91211306\|ref\|YP_541292.1\| histidinol dehydrogenase [Escherichia coli UTI89], gi\|91072880\|gb\|ABE07... gi\|75242853 - gi\|75242853\|ref\|ZP_00726559.1\| COG0141: Histidinol dehydrogenase [Escherichia coli F11]	650.0	[0..1]	[434..4]
gi\|75229119 - gi\|75229119\|ref\|ZP_00715694.1\| COG0141: Histidinol dehydrogenase [Escherichia coli B7A]	650.0	[0..1]	[434..4]
gi\|75214866 - gi\|75214866\|ref\|ZP_00713347.1\| COG0141: Histidinol dehydrogenase [Escherichia coli E110019] gi\|75210036 - gi\|75210036\|ref\|ZP_00710219.1\| COG0141: Histidinol dehydrogenase [Escherichia coli B171]	649.0	[0..1]	[434..4]
gi\|90411638, gi\|... - gi\|90411638\|ref\|ZP_01219648.1\| histidinol dehydrogenase [Photobacterium profundum 3TCK], gi\|90327528...	648.0	[0..9]	[434..6]
gi\|75514061 - gi\|75514061\|ref\|ZP_00736391.1\| COG0141: Histidinol dehydrogenase [Escherichia coli 53638]	648.0	[0..1]	[434..4]
gi\|75177147 - gi\|75177147\|ref\|ZP_00697245.1\| COG0141: Histidinol dehydrogenase [Shigella boydii BS512]	647.0	[0..1]	[434..4]
gi\|83571266 - gi\|83571266\|ref\|ZP_00922707.1\| COG0141: Histidinol dehydrogenase [Shigella dysenteriae 1012]	647.0	[0..1]	[434..4]

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Predicted Domain #1

Region A:
Residues: [1-434]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFNTIIDWN SCTAEQQRQL LMRPAISASE SITRTVNDIL DNVKARGDEA LREYSAKFDK  60
   61 TTVTALKVSA EEIAAASERL SDELKQAMAV AVKNIETFHT AQKLPPVDVE TQPGVRCQQV 120
  121 TRPVASVGLY IPGGSAPLFS TVLMLATPAS IAGCKKVVLC SPPPIADEIL YAAQLCGVQD 180
  181 VFNVGGAQAI AALAFGTESV PKVDKIFGPG NAFVTEAKRQ VSQRLDGAAI DMPAGPSEVL 240
  241 VIADSGATPD FVASDLLSQA EHGPDSQVIL LTPAADMARR VAEAVERQLA ELPRAETARQ 300
  301 ALNASRLIVT KDLAQCVEIS NQYGPEHLII QTRNARELVD SITSAGSVFL GDWSPESAGD 360
  361 YASGTNHVLP TYGYTATCSS LGLADFQKRM TVQELSKEGF SALASTIETL AAAERLTAHK 420
  421 NAVTLRVNAL KEQA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1k75A
Description:	L-histidinol dehydrogenase HisD
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	2.80804701752928	bayes_pls_golite062009
histidinol dehydrogenase activity	2.32012109012499	bayes_pls_golite062009
oxidoreductase activity	2.31275077585879	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	2.24875477727877	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	2.22720948878196	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: