YRC Public Data Repository - Protein Structure Prediction

Protein:	HIS6_CLOAB
Organism:	Clostridium acetobutylicum ATCC 824
Length:	253 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HIS6_CLOAB.

Description	E-value	Query Range	Subject Range
HIS6_GEODF - Imidazole glycerol phosphate synthase subunit HisF OS=Geobacter daltonii (strain DSM 22248 / JCM 158...	228.0	[0..1]	[253..1]
HIS6_GEOUR - Imidazole glycerol phosphate synthase subunit HisF OS=Geobacter uraniireducens (strain Rf4) GN=hisF ...	228.0	[0..1]	[253..1]
HIS6_THETN - Imidazole glycerol phosphate synthase subunit hisF OS=Thermoanaerobacter tengcongensis GN=hisF PE=3 ... HIS6_CALS4 - Imidazole glycerol phosphate synthase subunit HisF OS=Caldanaerobacter subterraneus subsp. tengconge...	227.0	[0..1]	[253..1]
gi\|118581458, gi... - gi\|71839788\|ref\|ZP_00679530.1\| Histidine biosynthesis protein HisF [Pelobacter propionicus DSM 2379]...	226.0	[0..1]	[253..1]
HIS6_GEOSL - Imidazole glycerol phosphate synthase subunit HisF OS=Geobacter sulfurreducens (strain ATCC 51573 / ... HIS6_GEOSL - Imidazole glycerol phosphate synthase subunit HisF OS=Geobacter sulfurreducens GN=hisF PE=3 SV=1	225.0	[0..1]	[253..1]
HIS6_PELTS - Imidazole glycerol phosphate synthase subunit HisF OS=Pelotomaculum thermopropionicum (strain DSM 13...	221.0	[0..1]	[253..1]
HIS6_GEOMG - Imidazole glycerol phosphate synthase subunit HisF OS=Geobacter metallireducens (strain GS-15 / ATCC...	221.0	[0..1]	[253..1]
HIS6_NITEC - Imidazole glycerol phosphate synthase subunit HisF OS=Nitrosomonas eutropha (strain C91) GN=hisF PE=...	219.0	[0..2]	[253..3]
gi\|110604130, gi... - gi\|110604130\|ref\|ZP_01392203.1\| imidazoleglycerol phosphate synthase, cyclase subunit [Methanoculleu...	219.0	[0..2]	[253..121]
gi\|166855778, gi... - gi\|76795716\|ref\|ZP_00778088.1\| Histidine biosynthesis protein HisF [Thermoanaerobacter ethanolicus A... gi\|242231369, gi... - gi\|242257127\|ref\|ZP_04802002.1\| imidazoleglycerol phosphate synthase, cyclase subunit [Thermoanaerob... gi\|241904120, gi... - gi\|241904120\|ref\|ZP_04788829.1\| imidazoleglycerol phosphate synthase, cyclase subunit [Thermoanaerob... HIS6_THEPX - Imidazole glycerol phosphate synthase subunit HisF OS=Thermoanaerobacter sp. (strain X514) GN=hisF P... gi\|255254033, gi... - gi\|255254033\|ref\|ZP_05333596.1\| imidazoleglycerol phosphate synthase, cyclase subunit [Thermoanaerob...	219.0	[0..1]	[253..1]

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Predicted Domain #1

Region A:
Residues: [1-253]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLTKRIIPCL DVDMGRVVKG VNFVNLKDVG DPVEIADFYN REGADEIVFL DISATNEGRN  60
   61 TMIDVVRRTA EKVFIPLTVG GGIRDVDDFK NILRAGADKI SINSAAIRNP ELINEAAKKF 120
  121 GSQCVVVAVD ARRNIETGGF NVFINGGRVD TSLDAIEWVK KCESLGAGEI LLTSMDADGT 180
  181 KNGYDVELTG AVCDAVRIPV IASGGCGRLE DFDEIFKKTS ADAALVASLF HYKEYTVGEV 240
  241 KNYLRENSIQ VRL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	45.221849
Match:	1ka9F
Description:	Cyclase subunit (or domain) of imidazoleglycerolphosphate synthase HisF
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
imidazoleglycerol-phosphate synthase activity	8.63799159510181	bayes_pls_golite062009
catalytic activity	2.44231061702877	bayes_pls_golite062009
transferase activity, transferring pentosyl groups	1.13340776845419	bayes_pls_golite062009
indole-3-glycerol-phosphate synthase activity	0.549444136526559	bayes_pls_golite062009
tryptophan synthase activity	0.426391242491024	bayes_pls_golite062009
lyase activity	0.258652421339738	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: