YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|7436002
Organism:	Synechocystis sp.
Length:	230 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|7436002.

Description	E-value	Query Range	Subject Range
HIS2_SYNY3 - Histidine biosynthesis bifunctional protein HisIE OS=Synechocystis sp. (strain PCC 6803 / Kazusa) GN... HIS2_SYNY3 - Histidine biosynthesis bifunctional protein HisIE OS=Synechocystis sp. (strain ATCC 27184 / PCC 6803...	321.0	[0..16]	[230..1]
gi\|25290311 - pir\|\|AH2213 histidine biosynthesis bifunctional protein (phosphoribosyl-AMP cyclohydrolase/phosphor... HIS2_NOSS1 - Histidine biosynthesis bifunctional protein HisIE OS=Nostoc sp. (strain PCC 7120 / UTEX 2576) GN=his...	321.0	[0..19]	[230..5]
gi\|75704839, gi\|... - gi\|75911114\|ref\|YP_325410.1\| bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrop...	320.0	[0..19]	[230..5]
gi\|56752110, gi\|... - gi\|56752110\|ref\|YP_172811.1\| bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrop... gi\|81300804, gi\|... - gi\|81300804\|ref\|YP_401012.1\| bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrop...	317.0	[0..22]	[230..3]
gi\|67924291, gi\|... - gi\|67924291\|ref\|ZP_00517727.1\| Phosphoribosyl-AMP cyclohydrolase:Phosphoribosyl-ATP pyrophosphohydro...	312.0	[0..19]	[230..6]
gi\|23129941, gi\|... - gi\|23129941\|ref\|ZP_00111762.1\| COG0139: Phosphoribosyl-AMP cyclohydrolase [Nostoc punctiforme PCC 73...	310.0	[0..16]	[230..1]
gi\|71671765, gi\|... - gi\|71674789\|ref\|ZP_00672535.1\| Phosphoribosyl-AMP cyclohydrolase:Phosphoribosyl-ATP pyrophosphohydro...	308.0	[0..21]	[229..7]
HIS2_CALS4 - Histidine biosynthesis bifunctional protein HisIE OS=Caldanaerobacter subterraneus subsp. tengcongen... HIS2_THETN - Histidine biosynthesis bifunctional protein hisIE OS=Thermoanaerobacter tengcongensis GN=hisI PE=3 S...	306.0	[0..27]	[230..2]
gi\|86607659 - gi\|86607659\|ref\|YP_476421.1\| histidine biosynthesis bifunctional protein HisIE [Cyanobacteria bacter... gi\|86556201, gi\|... - gi\|86607659\|ref\|YP_476421.1\| bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrop...	302.0	[0..27]	[229..2]
HIS2_THEEB - Histidine biosynthesis bifunctional protein HisIE OS=Thermosynechococcus elongatus (strain BP-1) GN=... HIS2_SYNEL - Histidine biosynthesis bifunctional protein hisIE OS=Synechococcus elongatus GN=hisI PE=3 SV=1	300.0	[0..26]	[230..7]

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Predicted Domain #1

Region A:
Residues: [1-138]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSRSAGRNS PILPLMSHSD LPLANAVPLD KIRYNDQGLV PAIAQDYLDG TVLMLAWMNE  60
   61 AALAKTLATG QVWYWSRSRQ ELWHKGATSG HFQKLLGIRY DCDSDALLLT IEQKGDIACH 120
  121 TGERSCFHQL DGHKSPPP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	43.30103
Match:	1zpsA
Description:	Crystal structure of Methanobacterium thermoautotrophicum phosphoribosyl-AMP cyclohydrolase HisI
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphoribosyl-AMP cyclohydrolase activity	4.150200144507	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	2.23740731288751	bayes_pls_golite062009
catalytic activity	1.39985329737364	bayes_pls_golite062009
cyclohydrolase activity	0.79104127517031	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	0.54834173729282	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [139-230]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ADMLTELARV IGDRRDHPTP ESYTCKLLAG GDNKILKKIG EESAEVVMAC KDDDPEAIAG  60
   61 EVADLFYHTL VALAHHNVDL RAVYRKLGDR RR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	27.0
Match:	1yvwA
Description:	Crystal structure of Phosphoribosyl-ATP pyrophosphohydrolase from Bacillus cereus. NESGC target BcR13.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphoribosyl-ATP diphosphatase activity	3.7001994388833	bayes_pls_golite062009
phosphoribosyl-AMP cyclohydrolase activity	2.61820126109961	bayes_pls_golite062009
catalytic activity	1.00486703080234	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	0.72725441841528	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: