YRC Public Data Repository - Protein Structure Prediction

Protein:	Y1029_STRPN
Organism:	Streptococcus pneumoniae TIGR4
Length:	543 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Y1029_STRPN.

Description	E-value	Query Range	Subject Range
gi\|147931000, gi... - gi\|149019625\|ref\|ZP_01834944.1\| 23S rRNA (uracil-5-)-methyltransferase RumA [Streptococcus pneumonia... gi\|25508684 - gi\|25508684\|pir\|\|D97988 conserved hypothetical protein spr0932 [imported] - Streptococcus pneumoniae... Y932_STRR6 - Uncharacterized RNA methyltransferase spr0932 OS=Streptococcus pneumoniae (strain ATCC BAA-255 / R6)... gi\|116515807, gi... - gi\|116515807\|ref\|YP_816392.1\| 23S rRNA (uracil-5-)-methyltransferase RumA [Streptococcus pneumoniae ... gi\|168483100, gi... - gi\|172043444\|gb\|EDT51490.1\| 23S rRNA (uracil-5-)-methyltransferase RumA [Streptococcus pneumoniae CD...	497.0	[0..1]	[543..1]
gi\|71903755, gi\|... - gi\|71903755\|ref\|YP_280558.1\| tRNA (uracil-5-)-methyltransferase [Streptococcus pyogenes MGAS6180], g...	495.0	[0..1]	[543..12]
gi\|255651934 - gi\|255651934\|ref\|ZP_05398836.1\| putative RNA methyltransferase [Clostridium difficile QCD-37x79] gi\|119633842, gi... - gi\|90572914\|ref\|ZP_01229435.1\| hypothetical protein CdifQ_02003735 [Clostridium difficile QCD-32g58]... gi\|254977015 - gi\|254977015\|ref\|ZP_05273487.1\| putative RNA methyltransferase [Clostridium difficile QCD-66c26]	485.0	[0..1]	[543..1]
gi\|33355823 - gi\|33355823\|gb\|AAQ16244.1\| RNA methyl transferase-like [Enterococcus faecalis]	464.0	[0..2]	[543..17]
gi\|42629793 - gi\|42629793\|ref\|ZP_00155338.1\| COG2265: SAM-dependent methyltransferases related to tRNA (uracil-5-)... gi\|229810512, gi... - gi\|229846419\|ref\|ZP_04466527.1\| 23S rRNA 5-methyluridine methyltransferase [Haemophilus influenzae 7...	433.0	[0..6]	[543..15]
Y687_BACHD - Uncharacterized RNA methyltransferase BH0687 OS=Bacillus halodurans GN=BH0687 PE=3 SV=1 Y687_BACHD - Uncharacterized RNA methyltransferase BH0687 OS=Bacillus halodurans (strain ATCC BAA-125 / DSM 18197...	401.0	[0..2]	[452..8]
gi\|56909112, gi\|... - gi\|56962873\|ref\|YP_174600.1\| S-adenosylmethionine (SAM)-dependent methyltransferase [Bacillus clausi...	400.0	[0..2]	[449..8]
Y363_BACC1 - Uncharacterized RNA methyltransferase BCE_0363 OS=Bacillus cereus (strain ATCC 10987 / NRS 248) GN=B...	397.0	[0..2]	[452..9]
gi\|51893956, gi\|... - gi\|51893956\|ref\|YP_076647.1\| RNA methyltransferase [Symbiobacterium thermophilum IAM 14863], gi\|5185...	396.0	[0..2]	[450..9]
Y364_BACCR - Uncharacterized RNA methyltransferase BC_0364 OS=Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2...	396.0	[0..2]	[448..9]

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Predicted Domain #1

Region A:
Residues: [1-441]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLKKNDIVEV EIVDLTHEGA GVAKVDGLVF FVENALPSEK ILMRVLKVNK KIGFGKVEKY  60
   61 LVQSPHRNQD LDLAYLRSGI ADLGHLSYPE QLKFKTKQVK DSLYKIAGIA DVEVAETLGM 120
  121 EHPVKYRNKA QVPVRRVNGV LETGFFRKNS HNLMPLEDFF IQDPVIDQVV VALRDLLRRF 180
  181 DLKPYDEKEQ SGLIRNLVVR RGHYSGQIMV VLVTTRPKVF RVDQLIEQVI KQFPEIVSVM 240
  241 QNINDQNTNA IFGKEWRTLY GQDYITDQML GNDFQIAGPA FYQVNTEMAE KLYQTAIDFA 300
  301 ELKKDDVIID AYSGIGTIGL SVAKHVKEVY GVELIPEAVE NSQKNASLNK ITNAHYVCDT 360
  361 AENAMKKWLK EGIQPTVILV DPPRKGLTES FIKASAQTGA DRIAYISCNV ATMARDIKLY 420
  421 QELGYELKKV QPVDLFPQTH H

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	78.522879
Match:	1uwvA
Description:	Crystal Structure of RumA, the iron-sulfur cluster containing E. coli 23S Ribosomal RNA 5-Methyluridine Methyltransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
methyltransferase activity	4.15445027778357	bayes_pls_golite062009
rRNA methyltransferase activity	4.09362182773099	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	4.07153733729662	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	3.39429041855776	bayes_pls_golite062009
RNA methyltransferase activity	3.07428840534971	bayes_pls_golite062009
N-methyltransferase activity	3.0539218951403	bayes_pls_golite062009
protein methyltransferase activity	3.01384869242051	bayes_pls_golite062009
transferase activity	2.22303238506686	bayes_pls_golite062009
tRNA methyltransferase activity	1.95598912777096	bayes_pls_golite062009
histone methyltransferase activity	1.90505369820945	bayes_pls_golite062009
rRNA (adenine) methyltransferase activity	1.83964463328968	bayes_pls_golite062009
rRNA (adenine-N6,N6-)-dimethyltransferase activity	1.75675289134467	bayes_pls_golite062009
DNA-methyltransferase activity	1.63765148226572	bayes_pls_golite062009
arginine N-methyltransferase activity	1.6030970825293	bayes_pls_golite062009
protein-arginine N-methyltransferase activity	1.6030970825293	bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds	1.33037840597912	bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds	1.33037840597912	bayes_pls_golite062009
aminoacyl-tRNA ligase activity	1.32901977260571	bayes_pls_golite062009
catalytic activity	1.25333584501255	bayes_pls_golite062009
rRNA (guanine) methyltransferase activity	1.10713374933008	bayes_pls_golite062009
histone-arginine N-methyltransferase activity	1.05897361334523	bayes_pls_golite062009
site-specific DNA-methyltransferase (adenine-specific) activity	0.703178429468566	bayes_pls_golite062009
protein-arginine omega-N monomethyltransferase activity	0.639377525568296	bayes_pls_golite062009
ligase activity	0.477367693545833	bayes_pls_golite062009
O-methyltransferase activity	0.250946859465502	bayes_pls_golite062009
tRNA (guanine) methyltransferase activity	0.203168546434167	bayes_pls_golite062009
protein-arginine omega-N asymmetric methyltransferase activity	0.130104080746388	bayes_pls_golite062009
histone methyltransferase activity (H4-R3 specific)	0.130042730841119	bayes_pls_golite062009
structure-specific DNA binding	0.00505175337890207	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [442-543]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VETVALLSKL DVDKHISVEI ELDEMDLTSA ESKATYAQIK EYVWNKFELK VSTLYIAQIK  60
   61 KKCGIELREH YNKSKKDKQI IPQCTPEKEE AIMDALRHFK MI

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.577	b.1.2	Fibronectin type III
View	Download	0.587	d.15.4	2Fe-2S ferredoxin-like
View	Download	0.547	a.74.1	Cyclin-like
View	Download	0.521	d.184.1	Non-globular alpha+beta subunits of globular proteins
View	Download	0.554	d.15.4	2Fe-2S ferredoxin-like

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: