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View Structure Prediction Details

Protein: SIGE_MYCTU
Organism: Mycobacterium tuberculosis H37Rv
Length: 257 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SIGE_MYCTU.

Description E-value Query
Range
Subject
Range
gi|196253313, gi... - gi|196253313|ref|ZP_03151946.1| RNA polymerase, sigma-24 subunit, ECF subfamily [Clostridium thermoc...
gi|67849833, gi|... - gi|67916230|ref|ZP_00509948.1| Sigma-70 region 2:Sigma-70 region 4 [Clostridium thermocellum ATCC 27...
177.0 [0..67] [245..3]
gi|25323335, gi|... - pir||F87043 ECF subfamily sigma subunit [imported] - Mycobacterium leprae, gi|13093076|emb|CAC31457....
gi|15827526 - gi|15827526|ref|NP_301789.1| RNA polymerase sigma factor SigE [Mycobacterium leprae TN]
gi|221230003, gi... - gi|221230003|ref|YP_002503419.1| ECF subfamily sigma subunit [Mycobacterium leprae Br4923], gi|21993...
175.0 [0..5] [257..10]
gi|221312309 - gi|221312309|ref|ZP_03594114.1| RNA polymerase sigma factor SigW [Bacillus subtilis subsp. subtilis ...
gi|221317242 - gi|221317242|ref|ZP_03598536.1| RNA polymerase sigma factor SigW [Bacillus subtilis subsp. subtilis ...
gi|221321505 - gi|221321505|ref|ZP_03602799.1| RNA polymerase sigma factor SigW [Bacillus subtilis subsp. subtilis ...
SIGW_BACSU - RNA polymerase sigma factor sigW OS=Bacillus subtilis GN=sigW PE=2 SV=1
SIGW_BACSU - ECF RNA polymerase sigma factor SigW OS=Bacillus subtilis (strain 168) GN=sigW PE=1 SV=1
169.0 [0..73] [242..9]
gi|89160528, gi|... - gi|89209876|ref|ZP_01188270.1| Sigma-70 region 2:Sigma-70 region 4 [Halothermothrix orenii H 168], g...
167.0 [0..64] [247..1]
gi|150390876, gi... - gi|77685958|ref|ZP_00801335.1| Sigma-70 region 2:Sigma-70 region 4 [Alkaliphilus metalliredigenes QY...
167.0 [0..67] [243..6]
gi|158140438, gi... - gi|158320239|ref|YP_001512746.1| ECF subfamily RNA polymerase sigma-24 factor [Alkaliphilus oremland...
166.0 [0..69] [246..5]
gi|2062634 - gi|2062634|gb|AAC45219.1| extracytoplasmic function alternative sigma factor [Mycobacterium avium]
gi|41408655, gi|... - gi|41408655|ref|NP_961491.1| RNA polymerase sigma factor SigE [Mycobacterium avium subsp. paratuberc...
165.0 [0..5] [254..4]
gi|92431764, gi|... - gi|92910591|ref|ZP_01279366.1| Sigma-70 region 2:Sigma-70 region 4 [Mycobacterium sp. JLS], gi|92431...
165.0 [0..1] [251..1]
gi|89085777, gi|... - gi|89099391|ref|ZP_01172267.1| RNA polymerase sigma-70 factor [Bacillus sp. NRRL B-14911], gi|890857...
165.0 [0..73] [241..9]
gi|88923028, gi|... - gi|88947512|ref|ZP_01150491.1| RNA polymerase ECF-type sigma factor [Desulfotomaculum reducens MI-1]...
162.0 [0..66] [254..2]

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Predicted Domain #1
Region A:
Residues: [1-257]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MELLGGPRVG NTESQLCVAD GDDLPTYCSA NSEDLNITTI TTLSPTSMSH PQQVRDDQWV  60
   61 EPSDQLQGTA VFDATGDKAT MPSWDELVRQ HADRVYRLAY RLSGNQHDAE DLTQETFIRV 120
  121 FRSVQNYQPG TFEGWLHRIT TNLFLDMVRR RARIRMEALP EDYDRVPADE PNPEQIYHDA 180
  181 RLGPDLQAAL ASLPPEFRAA VVLCDIEGLS YEEIGATLGV KLGTVRSRIH RGRQALRDYL 240
  241 AAHPEHGECA VHVNPVR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 34.69897
Match: 1or7A
Description: SigmaE factor (RpoE)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription initiation factor activity 5.71806750193815 bayes_pls_golite062009
sigma factor activity 5.58029806879061 bayes_pls_golite062009
transcription regulator activity 3.67872017549582 bayes_pls_golite062009
binding 1.02634976114785 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle