YRC Public Data Repository - Protein Structure Prediction

Protein:	HIS6_PSEAB
Organism:	Pseudomonas aeruginosa UCBPP-PA14
Length:	256 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HIS6_PSEAB.

Description	E-value	Query Range	Subject Range
gi\|67154753, gi\|... - gi\|67154753\|ref\|ZP_00416498.1\| Histidine biosynthesis protein HisF [Azotobacter vinelandii AvOP], re... HIS6_AZOVD - Imidazole glycerol phosphate synthase subunit HisF OS=Azotobacter vinelandii (strain DJ / ATCC BAA-1...	1.0E-59	[1..256]	[1..256]
HIS6_PSEA7 - Imidazole glycerol phosphate synthase subunit HisF OS=Pseudomonas aeruginosa (strain PA7) GN=hisF PE...	2.0E-59	[1..256]	[1..256]
gi\|94499843, gi\|... - gi\|94499843\|ref\|ZP_01306379.1\| Imidazoleglycerol-phosphate synthase [Oceanobacter sp. RED65], gi\|944...	3.0E-59	[1..256]	[1..256]
HIS6_ALCBS - Imidazole glycerol phosphate synthase subunit HisF OS=Alcanivorax borkumensis (strain ATCC 700651 / ...	6.0E-59	[1..256]	[1..256]
gi\|89083520, gi\|... - gi\|89092432\|ref\|ZP_01165386.1\| imidazole glycerol phosphate synthase subunit HisF [Oceanospirillum s...	6.0E-59	[1..256]	[1..256]
HIS6_PSEPF - Imidazole glycerol phosphate synthase subunit HisF OS=Pseudomonas fluorescens (strain Pf0-1) GN=hisF...	8.0E-59	[1..256]	[1..256]
HIS6_SACD2 - Imidazole glycerol phosphate synthase subunit HisF OS=Saccharophagus degradans (strain 2-40 / ATCC 4...	9.0E-59	[1..256]	[1..256]
gi\|95113090 - gi\|95113090\|emb\|CAK17818.1\| imidazole glycerol phosphate synthase, cyclase subunit [Pseudomonas] HIS6_PSEE4 - Imidazole glycerol phosphate synthase subunit HisF OS=Pseudomonas entomophila (strain L48) GN=hisF P...	1.0E-58	[1..256]	[1..256]
HIS6_PSEF5 - Imidazole glycerol phosphate synthase subunit HisF OS=Pseudomonas fluorescens (strain Pf-5 / ATCC BA...	2.0E-58	[1..256]	[1..256]
HIS6_PSEP1 - Imidazole glycerol phosphate synthase subunit HisF OS=Pseudomonas putida (strain F1 / ATCC 700007) G... tr\|I7B059\|I7B059... - Imidazole glycerol phosphate synthase subunit HisF OS=Pseudomonas putida (strain DOT-T1E) GN=hisF PE... HIS6_PSEPK - Imidazole glycerol phosphate synthase subunit HisF OS=Pseudomonas putida (strain KT2440) GN=hisF PE=...	2.0E-58	[1..256]	[1..256]

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Predicted Domain #1

Region A:
Residues: [1-256]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALAKRIIPC LDVDNGRVVK GVKFENIRDA GDPVEIARRY DEQGADEITF LDITASVDGR  60
   61 DTTLHTVERM ASQVFIPLTV GGGVRSVQDI RNLLNAGADK VSINTAAVFN PEFVGEAADR 120
  121 FGSQCIVVAI DAKKVSAPGE APRWEIFTHG GRKPTGLDAV LWAKKMEDLG AGEILLTSMD 180
  181 QDGVKSGYDL GVTRAISEAV NVPVIASGGV GNLEHLAAGI LEGKADAVLA ASIFHFGEYT 240
  241 VPEAKAYLAS RGIVVR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	47.69897
Match:	1ka9F
Description:	Cyclase subunit (or domain) of imidazoleglycerolphosphate synthase HisF
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
imidazoleglycerol-phosphate synthase activity	8.63799159510181	bayes_pls_golite062009
catalytic activity	2.44231061702877	bayes_pls_golite062009
transferase activity, transferring pentosyl groups	1.13340776845419	bayes_pls_golite062009
indole-3-glycerol-phosphate synthase activity	0.549444136526559	bayes_pls_golite062009
tryptophan synthase activity	0.426391242491024	bayes_pls_golite062009
lyase activity	0.258652421339738	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: