YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|15606301, gi\|...
Organism:	Aquifex aeolicus VF5
Length:	198 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|15606301, gi|....

Description	E-value	Query Range	Subject Range
gi\|5458403, gi\|7... - pir\|\|F75073 pyrazinamidase/nicotinamidase PAB1720 - Pyrococcus abyssi (strain Orsay), gi\|5458403\|em... gi\|5458403, gi\|1... - gi\|5458403\|emb\|CAB49891.1\| Amidase related to nicotinamidase [Pyrococcus abyssi GE5], gi\|14521185\|re...	202.0	[0..5]	[189..1]
gi\|57159909, gi\|... - gi\|57641585\|ref\|YP_184063.1\| nicotinamidase [Thermococcus kodakarensis KOD1], gi\|57159909\|dbj\|BAD858...	200.0	[0..7]	[188..2]
gi\|14590841, gi\|... - gi\|3257413\|dbj\|BAA30096.1\| 180aa long hypothetical pyrazinamidase/nicotinamidase [Pyrococcus horikos... gi\|17943390, gi\|... - pir\|\|B71092 probable pyrazinamidase/nicotinamidase - Pyrococcus horikoshii, gi\|17943390\|pdb\|1ILW\|A ...	199.0	[0..10]	[188..5]
gi\|18977477, gi\|... - gi\|18977477\|ref\|NP_578834.1\| pyrazinamidase/nicotinamidase pxnc [Pyrococcus furiosus DSM 3638], gi\|1...	195.0	[0..5]	[188..1]
gi\|82702035, gi\|... - gi\|82702035\|ref\|YP_411601.1\| isochorismatase hydrolase [Nitrosospira multiformis ATCC 25196], gi\|824...	193.0	[0..1]	[194..1]
gi\|53803102, gi\|... - gi\|53803102\|ref\|YP_115158.1\| pyrazinamidase/nicotinamidase, putative [Methylococcus capsulatus str. ...	189.0	[0..10]	[189..15]
gi\|39997388, gi\|... - gi\|39997388\|ref\|NP_953339.1\| pyrazinamidase/nicotinamidase, putative [Geobacter sulfurreducens PCA],...	183.0	[0..5]	[198..1]
gi\|238794512, gi... - gi\|77977679\|ref\|ZP_00833121.1\| COG1335: Amidases related to nicotinamidase [Yersinia intermedia ATCC...	180.0	[0..7]	[194..1]
gi\|161485914 - gi\|161485914\|ref\|NP_707345.2\| nicotinamidase/pyrazinamidase [Shigella flexneri 2a str. 301] gi\|161486495 - gi\|161486495\|ref\|NP_837140.2\| nicotinamidase/pyrazinamidase [Shigella flexneri 2a str. 2457T] gi\|110805425, gi... - gi\|110805425\|ref\|YP_688945.1\| nicotinamidase/pyrazinamidase [Shigella flexneri 5 str. 8401], gi\|1106...	179.0	[0..5]	[197..1]
gi\|24051771, gi\|... - gi\|24112835\|ref\|NP_707345.1\| hypothetical protein SF1455 [Shigella flexneri 2a str. 301], gi\|2405177... gi\|30062969, gi\|... - gi\|30062969\|ref\|NP_837140.1\| hypothetical protein S1570 [Shigella flexneri 2a str. 2457T], gi\|300412...	179.0	[0..5]	[197..7]

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Predicted Domain #1

Region A:
Residues: [1-198]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKVKLTDRDA LIVVDMQKDF MPGGALPVPE GDKIIPRINE YVKLFEKKGL PVFYTRDWHP  60
   61 ENHISFKGHG GIWPPHCVQG TEGAKFHEDL YIPADNKFII SKGTSQEFDA YSGFQGTILN 120
  121 DLLKERGVRR IFVCGVATDY CVKNTTIGGI NLGYQAFVLE DAIKGVDVNP GDVERAINEM 180
  181 MERGAAFIKI EDIVDYKK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	51.30103
Match:	1ilwA
Description:	Pyrazinamidase/nicotinamidase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
nicotinamidase activity	2.590271821288	bayes_pls_golite062009
binding	1.80707112356899	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	1.33901087189475	bayes_pls_golite062009
catalytic activity	0.992051062697807	bayes_pls_golite062009
protein binding	0.343971697425971	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: