YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|30258971, gi\|...
Organism:	Bacillus anthracis str. Ames
Length:	1132 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|30258971, gi|....

Description	E-value	Query Range	Subject Range
METH_VIBPA - Methionine synthase OS=Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) GN=metH PE=3 SV=... gi\|153840028, gi... - gi\|153840028\|ref\|ZP_01992695.1\| methionine synthase [Vibrio parahaemolyticus AQ3810], gi\|149746415\|g... METH_VIBPA - Methionine synthase OS=Vibrio parahaemolyticus GN=metH PE=3 SV=1	0.0	[2..1131]	[7..1194]
gi\|91189767, gi\|... - gi\|91225647\|ref\|ZP_01260721.1\| B12-dependent methionine synthase [Vibrio alginolyticus 12G01], gi\|91...	0.0	[2..1131]	[7..1194]
METH_ALIFS - Methionine synthase OS=Aliivibrio fischeri GN=metH PE=3 SV=1	0.0	[2..1131]	[8..1195]
METH_VIBF1 - Methionine synthase OS=Vibrio fischeri (strain ATCC 700601 / ES114) GN=metH PE=3 SV=1	0.0	[2..1131]	[8..1195]
gi\|121630369, gi... - gi\|75816808\|ref\|ZP_00747268.1\| COG1410: Methionine synthase I, cobalamin-binding domain [Vibrio chol... gi\|121548155, gi... - gi\|121587582\|ref\|ZP_01677347.1\| 5-methyltetrahydrofolate--homocysteine methyltransferase [Vibrio cho... gi\|124118339, gi... - gi\|153223242\|ref\|ZP_01953739.1\| 5-methyltetrahydrofolate--homocysteine methyltransferase [Vibrio cho... gi\|126520229, gi... - gi\|229508815\|ref\|ZP_04398307.1\| 5-methyltetrahydrofolate--homocysteine methyltransferase [Vibrio cho... METH_VIBCH - Methionine synthase OS=Vibrio cholerae GN=metH PE=3 SV=1 gi\|227080601, gi... - gi\|227080601\|ref\|YP_002809152.1\| 5-methyltetrahydrofolate--homocysteine methyltransferase [Vibrio ch... gi\|229344492, gi... - gi\|229519803\|ref\|ZP_04409246.1\| 5-methyltetrahydrofolate--homocysteine methyltransferase [Vibrio cho... gi\|229368983, gi... - gi\|229606328\|ref\|YP_002876976.1\| 5-methyltetrahydrofolate--homocysteine methyltransferase [Vibrio ch... gi\|254850622, gi... - gi\|75829069\|ref\|ZP_00758388.1\| COG1410: Methionine synthase I, cobalamin-binding domain [Vibrio chol... METH_VIBCH - Methionine synthase OS=Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) GN=metH... gi\|75828368, gi\|... - gi\|75828368\|ref\|ZP_00757803.1\| COG1410: Methionine synthase I, cobalamin-binding domain [Vibrio chol...	0.0	[2..1131]	[7..1194]
gi\|75855204, gi\|... - gi\|75855204\|ref\|ZP_00762863.1\| COG1410: Methionine synthase I, cobalamin-binding domain [Vibrio sp. ...	0.0	[2..1131]	[7..1194]
gi\|125621484, gi... - gi\|75819730\|ref\|ZP_00749797.1\| COG1410: Methionine synthase I, cobalamin-binding domain [Vibrio chol...	0.0	[2..1131]	[7..1194]
gi\|54310381, gi\|... - gi\|54310381\|ref\|YP_131401.1\| B12-dependent methionine synthase [Photobacterium profundum SS9], gi\|46...	0.0	[4..1131]	[9..1193]
gi\|254223014, gi... - gi\|254223014\|ref\|ZP_04916876.1\| 5-methyltetrahydrofolate--homocysteine methyltransferase [Vibrio cho... tr\|D7HD92\|D7HD92... - 5-methyltetrahydrofolate-homocysteine methyltransferase OS=Vibrio cholerae RC385 GN=VCRC385_00259 PE...	0.0	[2..1131]	[7..1194]
gi\|90412960, gi\|... - gi\|90412960\|ref\|ZP_01220958.1\| putative cobalamin-dependent methionine synthase [Photobacterium prof...	0.0	[4..1131]	[9..1193]

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Predicted Domain #1

Region A:
Residues: [1-601]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYCIEEKLQN NILLLDGAMG TMIQQEDLTA EDFGGEEYEG CNEYLVETRP DVILKIHKAY  60
   61 IEAGADIIET NTFGATNIVL SDYELSHLDE ELNEKAARLA KQAVKESGKE VYVAGAMGPT 120
  121 TKAISVTGGV TFEELIEAYT RQARGLLKGE VDVLLVETSQ DMRNMKAAYI GIQAAFDELK 180
  181 KIVPIMISGT IEPMGTTLAG QTIEAFYLSV EHMKPLSVGL NCATGPEFMR DHIRSLSDLS 240
  241 ECYISCYPNA GLPDEDGHYH ESPSSLAEKV KRFAEEGWVN IIGGCCGTTP EHIKAMKEAL 300
  301 ASLKPREHHE REGHGVSGLE ALQYDDSMRP LFVGERTNVI GSRKFKRLVA EGKFEEAAEV 360
  361 ARAQVKKNAH IIDICMADPD RDEIEDMENF LAEVTKVLKV PIMIDSTDEH VMERALTYIQ 420
  421 GKAVINSINL EDGEERFIKV TPLLQKYGAA IVVGTIDEDG MAVSAERKLE IAKRSYELLT 480
  481 TKYGIRPSDI IFDALVFPVG TGDEEYIGSA AATIEGIRLI KEALPECLTI LGVSNISFGL 540
  541 PPAGREVLNS VFLYHATKAG LDYAIVNTEK LERYASIPDE EKRLADALLF ETTQETLEEF 600
  601 T

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	117.0
Match:	1q7mA
Description:	Cobalamin-dependent methionine synthase (MetH) from Thermotoga maritima (Oxidized, Monoclinic)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
dihydropteroate synthase activity	5.55484533231129	bayes_pls_golite062009
S-methyltransferase activity	3.53817178180686	bayes_pls_golite062009
methyltransferase activity	3.47355858135695	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	3.39246539615995	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	3.30536381024187	bayes_pls_golite062009
transferase activity	2.35234138809715	bayes_pls_golite062009
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity	1.59882258515727	bayes_pls_golite062009
catalytic activity	1.41033217274476	bayes_pls_golite062009
transferase activity, transferring alkyl or aryl (other than methyl) groups	1.09502814971491	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.775834109629976	bayes_pls_golite062009
binding	0.660910809839792	bayes_pls_golite062009
dihydroneopterin aldolase activity	0.570043482286316	bayes_pls_golite062009
protein binding	0.422094211438801	bayes_pls_golite062009
diphosphotransferase activity	0.246882532482481	bayes_pls_golite062009
methionine synthase activity	0.191040886553873	bayes_pls_golite062009
5-methyltetrahydrofolate-dependent methyltransferase activity	0.191040886553873	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [602-1132]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NFYRVAKKKD VVVQETLTLD ERLANYIVEG TKQGLHEDLS LALTEGRKPL DIINGPLMTG  60
   61 MDEVGRLFNN NELIVAEVLQ SAESMKAAVS YLEPHMESSD SAKKGKVLLA TVKGDVHDIG 120
  121 KNLVEIILAN NGYEIINLGI NVRSDRIVQE VQEKKPDIIG LSGLLVKSAQ QMVTTAEDLK 180
  181 AADIDIPIVV GGAALTRKFT DNRISPSYKG LVCYASDAMT GLDIINKLQK EEEREKMKQD 240
  241 KKERHLHIVT KEEKKIEIPA VIEPLPKSEV MVPDSTKRIV LRDVPALHLA PFLNRQMLLG 300
  301 HHLGLKGSVK KLLKEGDKRA HELNDLIDEL LQEGQSWLKP KAVYQFFPAQ SDGQNIVIYD 360
  361 PEDHTRVIER FTFPRQGRAP YRTLGDYLRP IGDEMDYVAF LSVTVGEGVR GIAEEWKAKG 420
  421 DYLRSHAIQS LALELAEGLA EKTHMLIRDR WGIPDSPELT MEERFRTKYR GIRVSFGYPA 480
  481 CPELADQEKL FRLIHPEEIG ISLTEGFMME PEASVTAMVF SHPEARYFSV L

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	180.0
Match:	1k7yA
Description:	Methionine synthase domain; Methionine synthase, C-terminal domain; Methionine synthase SAM-binding domain
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: