YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|30262986, gi\|...
Organism:	Bacillus anthracis str. Ames
Length:	584 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|30262986, gi|....

Description	E-value	Query Range	Subject Range
Y3012_BACCR - Putative adenine deaminase BC_3012 OS=Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC ...	0.0	[1..584]	[6..589]
gi\|49480044, gi\|... - gi\|49480044\|ref\|YP_037090.1\| adenine deaminase [Bacillus thuringiensis serovar konkukian str. 97-27]...	0.0	[1..584]	[1..584]
gi\|51975958, gi\|... - gi\|52142489\|ref\|YP_084340.1\| adenine deaminase [Bacillus cereus E33L], gi\|51975958\|gb\|AAU17508.1\| ad...	0.0	[6..584]	[11..589]
gi\|47568608, gi\|... - gi\|47568608\|ref\|ZP_00239306.1\| adenine deaminase, putative [Bacillus cereus G9241], gi\|47554704\|gb\|E...	0.0	[6..584]	[11..589]
gi\|75763267, gi\|... - gi\|75763267\|ref\|ZP_00743019.1\| Adenine deaminase [Bacillus thuringiensis serovar israelensis ATCC 35...	0.0	[1..584]	[6..589]
ADEC_MOOTA - Adenine deaminase OS=Moorella thermoacetica (strain ATCC 39073) GN=ade PE=3 SV=1	0.0	[5..576]	[4..593]
gi\|163940762, gi... - gi\|89207142\|ref\|ZP_01185689.1\| Adenine deaminase [Bacillus weihenstephanensis KBAB4], gi\|89154927\|gb...	0.0	[1..578]	[1..578]
ADEC_LISMO - Adenine deaminase OS=Listeria monocytogenes GN=ade PE=3 SV=1 ADEC_LISMO - Adenine deaminase OS=Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) GN=ade PE=3 S...	0.0	[11..579]	[6..580]
ADEC_LISIN - Adenine deaminase OS=Listeria innocua GN=ade PE=3 SV=1 ADEC_LISIN - Adenine deaminase OS=Listeria innocua serovar 6a (strain CLIP 11262) GN=ade PE=3 SV=1	0.0	[11..579]	[5..579]
gi\|47015953, gi\|... - gi\|47095668\|ref\|ZP_00233275.1\| adenine deaminase [Listeria monocytogenes str. 1/2a F6854], gi\|470159... gi\|254900753, gi... - gi\|254900753\|ref\|ZP_05260677.1\| hypothetical protein LmonJ_13094 [Listeria monocytogenes J0161], gi\|... gi\|133732606, gi... - gi\|254938149\|ref\|ZP_05269846.1\| hypothetical protein LmonF6_13514 [Listeria monocytogenes F6900], gi... gi\|153191213, gi... - gi\|254913762\|ref\|ZP_05263774.1\| hypothetical protein LmonJ2_13234 [Listeria monocytogenes J2818], gi...	0.0	[11..579]	[5..579]

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Predicted Domain #1

Region A:
Residues: [1-423]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGQNQFRWSN EQLREHVEII DGTRSPHKLL KNATYLNSYI REWMQANIWI YDDRIIYVGE  60
   61 KLPEQLHECE VIDCDGKYVV PSYIEPHAHP YQLYNPETLA NHAMQFGTTT FINDNLTLFF 120
  121 TLKREESFHL LDEFTKIPAS MYWWCRFDGQ TELQNGESLF NSEEIIKWLQ HEAVLQGGEL 180
  181 TAWPKLLHGD DEMLTWVQET KRLQKKVEGH FPGASEATLA KLKLLGTDCD HEAMTGQEAL 240
  241 ARLMQGYTVS LRNSSIRPDL EVLLKELLEL GVKQFDRFIF TTDGSHPSFY ENGMTNIMIA 300
  301 TAIKKGIPVI DAYQMASYNI ARYYNMEHIH GAIATGRIAN INILESKENP VPTSVIAKGQ 360
  361 WVKRDGVNTH EALHIDWSKC KVTPLSLEWS IEKEDMLFSN KTGIHLLNNV ITKPYTSEIN 420
  421 IDC

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	47.69897
Match:	1e9zB
Description:	alpha-Subunit of urease; alpha-subunit of urease, catalytic domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	2.09478447332528	bayes_pls_golite062009
catalytic activity	2.072432847481	bayes_pls_golite062009
hydrolase activity	2.06578679075873	bayes_pls_golite062009
deaminase activity	2.00485136695944	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	1.2382202418205	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	0.97576964967771	bayes_pls_golite062009
adenine deaminase activity	0.56372605168514	bayes_pls_golite062009
dihydroorotase activity	0.44266757158292	bayes_pls_golite062009
guanine deaminase activity	0.22133469174284	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [424-584]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DELSIDYDEC FLMMIARDGT WRVNTVVKGF AKEIGGLASS YSGTGDIILV GKRKEDMLTA  60
   61 FHRIKELGGG MVIAEKNEVL HEIALPLLGI MSELKMSELI QKEKKMVNLL QERGYVYNDP 120
  121 AFTILFFSAT HLPFIRVTFI GLYDVKSGKV VASPVNLIKQ Y

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.587	0.812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	c.2.1	NAD(P)-binding Rossmann-fold domains
View	Download	0.556	0.812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	c.55.3	Ribonuclease H-like
View	Download	0.487	0.812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	c.3.1	FAD/NAD(P)-binding domain
View	Download	0.512	0.812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	c.57.1	Molybdenum cofactor biosynthesis proteins
View	Download	0.563	0.812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	c.2.1	NAD(P)-binding Rossmann-fold domains

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: