YRC Public Data Repository - Protein Structure Prediction

Protein:	HIS4_GEOSL
Organism:	Geobacter sulfurreducens PCA
Length:	244 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HIS4_GEOSL.

Description	E-value	Query Range	Subject Range
HIS4_PROM4 - 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase O...	205.0	[0..1]	[239..1]
gi\|7437379 - pir\|\|S76756 1-(5-phosphoribosyl)-5-[ (5-phosphoribosylamino)methylideneamino)imidazole-4-carboxam id... HIS4_SYNY3 - 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase O... HIS4_SYNY3 - 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase O...	203.0	[0..1]	[243..1]
gi\|83747543, gi\|... - gi\|83747543\|ref\|ZP_00944581.1\| Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomera...	202.0	[0..1]	[244..1]
HIS4_RALSO - 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase O... HIS4_RALSO - 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase O...	202.0	[0..1]	[244..1]
HIS4_BURVG - 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase O... gi\|229424439 - gi\|229424439\|gb\|ACQ65656.1\| phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase ...	202.0	[0..1]	[241..1]
gi\|45528492, gi\|... - gi\|67920558\|ref\|ZP_00514078.1\| Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomera...	202.0	[0..1]	[243..1]
HIS4_BURCA - 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase O... HIS4_BURCC - 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase O... gi\|158343902, gi... - gi\|158343982\|gb\|ABW35777.1\| phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase ... gi\|124871300, gi... - gi\|254246524\|ref\|ZP_04939845.1\| Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomer... HIS4_BURCJ - 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase O...	201.0	[0..1]	[241..1]
HIS4_PROM9 - 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase O...	201.0	[0..1]	[243..1]
HIS4_BURCH - 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase O...	201.0	[0..1]	[241..1]
gi\|91204079 - gi\|91204079\|emb\|CAJ71732.1\| strongly similar to 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methy...	200.0	[0..1]	[238..1]

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Predicted Domain #1

Region A:
Residues: [1-244]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIVIPAIDLK EGKCVRLEQG LMEKDTVFCD NPADQAREWE RQGAELLHIV DLDGAFAGEP  60
   61 KNRASIEAIV KAIAIPTQLG GGIRDIPTIE AYLSLGIGRV ILGTAAQRNP ELVEEACRLF 120
  121 PGRIVVGIDA KNGMVAVQGW AEVTGVTAVD LAKRFEGYGV AAIIYTDIAR DGMMQGPNIE 180
  181 ATRALAEAIS IPVIASGGVS SLKDIENLMA IETSGIAGAI TGKAVYTGAI NLAEAVALTK 240
  241 RGGA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	42.221849
Match:	1vzwA
Description:	Crystal structure of the bifunctional protein Pria
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
imidazoleglycerol-phosphate synthase activity	8.63799159510181	bayes_pls_golite062009
catalytic activity	2.44231061702877	bayes_pls_golite062009
transferase activity, transferring pentosyl groups	1.13340776845419	bayes_pls_golite062009
indole-3-glycerol-phosphate synthase activity	0.549444136526559	bayes_pls_golite062009
tryptophan synthase activity	0.426391242491024	bayes_pls_golite062009
lyase activity	0.258652421339738	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: