YRC Public Data Repository - Protein Structure Prediction

Protein:	HIS2_GEOSL
Organism:	Geobacter sulfurreducens PCA
Length:	108 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HIS2_GEOSL.

Description	E-value	Query Range	Subject Range
HIS2_GEOMG - Phosphoribosyl-ATP pyrophosphatase OS=Geobacter metallireducens (strain GS-15 / ATCC 53774 / DSM 721...	150.0	[0..1]	[108..1]
HIS2_HELHP - Histidine biosynthesis bifunctional protein HisIE OS=Helicobacter hepaticus (strain ATCC 51449 / 3B1... HIS2_HELHP - Histidine biosynthesis bifunctional protein HisIE OS=Helicobacter hepaticus GN=hisI PE=3 SV=1	148.0	[0..7]	[107..130]
gi\|77920274, gi\|... - gi\|77920274\|ref\|YP_358089.1\| phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphatase [...	148.0	[0..3]	[107..108]
gi\|23015841 - gi\|23015841\|ref\|ZP_00055607.1\| COG0140: Phosphoribosyl-ATP pyrophosphohydrolase [Magnetospirillum ma...	147.0	[0..1]	[108..1]
gi\|95134905, gi\|... - gi\|95929004\|ref\|ZP_01311749.1\| phosphoribosyl-AMP cyclohydrolase [Desulfuromonas acetoxidans DSM 684...	146.0	[0..6]	[108..128]
HIS2_MAGSA - Phosphoribosyl-ATP pyrophosphatase OS=Magnetospirillum magneticum (strain AMB-1 / ATCC 700264) GN=hi...	146.0	[0..1]	[108..1]
gi\|83653991, gi\|... - gi\|83720166\|ref\|YP_443489.1\| phosphoribosyl-ATP pyrophosphohydrolase [Burkholderia thailandensis E26...	146.0	[0..5]	[108..80]
gi\|88936602, gi\|... - gi\|88936602\|ref\|ZP_01142207.1\| phosphoribosyl-ATP pyrophosphohydrolase [Geobacter uraniumreducens Rf...	145.0	[0..3]	[108..2]
gi\|71671765, gi\|... - gi\|71674789\|ref\|ZP_00672535.1\| Phosphoribosyl-AMP cyclohydrolase:Phosphoribosyl-ATP pyrophosphohydro...	144.0	[0..6]	[97..126]
gi\|110547958, gi... - gi\|110601325\|ref\|ZP_01389517.1\| Phosphoribosyl-ATP pyrophosphohydrolase [Geobacter sp. FRC-32], gi\|1...	143.0	[0..1]	[106..1]

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Predicted Domain #1

Region A:
Residues: [1-108]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNERDDILQA VYEVILDRKG ALPESSYTAS LFHKGIDKIL KKVGEEATEV IIAGKGGKRE  60
   61 EIVYETADLL FHTLVLLGHY DIAPADVYNE LRRRFGTSGH AEKASRNE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	32.221849
Match:	2a7wA
Description:	Crystal Structure of Phosphoribosyl-ATP Pyrophosphatase from Chromobacterium violaceum (ATCC 12472). NESG TARGET CVR7
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphoribosyl-ATP diphosphatase activity	3.7001994388833	bayes_pls_golite062009
phosphoribosyl-AMP cyclohydrolase activity	2.61820126109961	bayes_pls_golite062009
catalytic activity	1.00486703080234	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	0.72725441841528	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: