YRC Public Data Repository - Protein Structure Prediction

Protein:	FOLD2_GEOSL
Organism:	Geobacter sulfurreducens PCA
Length:	285 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FOLD2_GEOSL.

Description	E-value	Query Range	Subject Range
FOLD_MAGMM - Bifunctional protein FolD OS=Magnetococcus marinus (strain ATCC BAA-1437 / JCM 17883 / MC-1) GN=folD... sp\|A0LE04\|FOLD_MAGMM - Bifunctional protein FolD OS=Magnetococcus marinus (strain ATCC BAA-1437 / JCM 17883 / MC-1) GN=folD...	420.0	[0..1]	[282..1]
FOLD_MOOTA - Bifunctional protein FolD OS=Moorella thermoacetica (strain ATCC 39073) GN=folD PE=3 SV=1	419.0	[0..2]	[279..3]
gi\|114550889, gi... - gi\|114778854\|ref\|ZP_01453653.1\| 5,10-methylene-tetrahydrofolate dehydrogenase/cyclohydrolase [Maripr...	406.0	[0..2]	[283..6]
gi\|67153449 - gi\|67153449\|ref\|ZP_00415194.1\| Methenyltetrahydrofolate cyclohydrolase [Azotobacter vinelandii AvOP] FOLD_AZOVD - Bifunctional protein FolD OS=Azotobacter vinelandii (strain DJ / ATCC BAA-1303) GN=folD PE=3 SV=1	405.0	[0..2]	[281..3]
FOLD_GEODF - Bifunctional protein FolD OS=Geobacter daltonii (strain DSM 22248 / JCM 15807 / FRC-32) GN=folD PE=3...	404.0	[0..1]	[280..1]
FOLD_BACSU - Bifunctional protein FolD OS=Bacillus subtilis (strain 168) GN=folD PE=3 SV=1 FOLD_BACSU - Bifunctional protein FolD OS=Bacillus subtilis GN=folD PE=3 SV=1 gi\|221323877 - gi\|221323877\|ref\|ZP_03605171.1\| methenyltetrahydrofolate cyclohydrolase [Bacillus subtilis subsp. su... gi\|221319601 - gi\|221319601\|ref\|ZP_03600895.1\| methenyltetrahydrofolate cyclohydrolase [Bacillus subtilis subsp. su... gi\|221314678 - gi\|221314678\|ref\|ZP_03596483.1\| methenyltetrahydrofolate cyclohydrolase [Bacillus subtilis subsp. su...	404.0	[0..2]	[279..3]
FOLD_CUPNH - Bifunctional protein FolD OS=Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) G...	404.0	[0..2]	[282..3]
SO1792 - methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase FOLD_SHEON - Bifunctional protein FolD OS=Shewanella oneidensis (strain MR-1) GN=folD PE=3 SV=1	404.0	[0..2]	[281..3]
gi\|116107329, gi... - gi\|116511675\|ref\|YP_808891.1\| methenyltetrahydrofolate cyclohydrolase [Lactococcus lactis subsp. cre...	404.0	[0..4]	[284..13]
gi\|229546825, gi... - gi\|229546825\|ref\|ZP_04435550.1\| methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyc... gi\|227175756, gi... - gi\|227555088\|ref\|ZP_03985135.1\| methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyc... gi\|227074655, gi... - gi\|227517901\|ref\|ZP_03947950.1\| methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyc... FOLD_ENTFA - Bifunctional protein FolD OS=Enterococcus faecalis (strain ATCC 700802 / V583) GN=folD PE=3 SV=1 FOLD_ENTFA - Bifunctional protein FolD OS=Enterococcus faecalis GN=folD PE=3 SV=1 gi\|238829896, gi... - gi\|238857535\|ref\|ZP_04647771.1\| bifunctional protein FolD [Enterococcus faecalis TUSoD Ef11], gi\|238... gi\|229305940, gi... - gi\|229548919\|ref\|ZP_04437644.1\| methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyc...	404.0	[0..1]	[280..1]

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Predicted Domain #1

Region A:
Residues: [1-285]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATIIDGKAI AEKIRADLAA QVKELQSRGI TPGLATVLVG SDPASEVYVR MKGDACNKLG  60
   61 MHSVKITRPA ETTEEELLAL INELNNDPAI HGILVQLPLP PQINADRVLE AISPAKDVDG 120
  121 FHPYNVGRLV TGKPTFQPCT PYGVMVMLQE AGVDLAGKEV VVVGRSNIVG KPVALMCLQR 180
  181 NATVTICHSK TRDLPGRVRA ADVVIAAVGV PEMIKGDWIK EGAVVIDVGV NRVGEKKLVG 240
  241 DVEFAAAAER ASAITPVPGG VGPMTITMLL HNTLEAAKMA GSGNR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	111.0
Match:	1b0aA
Description:	Methylenetetrahydrofolate dehydrogenase/cyclohydrolase; Tetrahydrofolate dehydrogenase/cyclohydrolase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity	3.54983447672782	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	2.66605122152932	bayes_pls_golite062009
malate dehydrogenase activity	2.43636049081724	bayes_pls_golite062009
catalytic activity	2.0643953589843	bayes_pls_golite062009
methenyltetrahydrofolate cyclohydrolase activity	1.95551536198286	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.54527841865655	bayes_pls_golite062009
malic enzyme activity	1.39067036188188	bayes_pls_golite062009
binding	1.14588824263074	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	0.66392365734856	bayes_pls_golite062009
cyclohydrolase activity	0.129148522173579	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: