YRC Public Data Repository - Protein Structure Prediction

Protein:	DEF2_COXBU
Organism:	Coxiella burnetii RSA 493
Length:	209 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DEF2_COXBU.

Description	E-value	Query Range	Subject Range
gi\|95928185, gi\|... - gi\|95928185\|ref\|ZP_01310935.1\| hypothetical protein CburR_01000110 [Coxiella burnetii RSA 331], gi\|1...	236.0	[0..1]	[209..1]
gi\|165919286, gi... - gi\|165919286\|ref\|ZP_02219372.1\| peptide deformylase [Coxiella burnetii RSA 334], gi\|165917009\|gb\|EDR... gi\|153206215, gi... - gi\|153206215\|ref\|ZP_01945478.1\| peptide deformylase [Coxiella burnetii 'MSU Goat Q177'], gi\|12057734... gi\|154705784, gi... - gi\|94492754\|ref\|ZP_01299961.1\| hypothetical protein CburD_01000340 [Coxiella burnetii Dugway 7E9-12]...	235.0	[0..1]	[209..1]
gi\|49081366 - gi\|49081366\|gb\|AAT50122.1\| PA0019 [synthetic construct]	219.0	[0..1]	[188..4]
gi\|33357406, gi\|... - gi\|47168959\|pdb\|1S17\|B Chain B, Identification Of Novel Potent Bicyclic Peptide Deformylase Inhibito...	219.0	[0..1]	[183..16]
gi\|116053739, gi... - gi\|53726911\|ref\|ZP_00140421.2\| COG0242: N-formylmethionyl-tRNA deformylase [Pseudomonas aeruginosa U...	219.0	[0..1]	[183..4]
gi\|70733535, gi\|... - gi\|70733535\|ref\|YP_257174.1\| peptide deformylase [Pseudomonas fluorescens Pf-5], gi\|68347834\|gb\|AAY9...	219.0	[0..1]	[183..49]
gi\|126196509, gi... - gi\|84324767\|ref\|ZP_00972822.1\| COG0242: N-formylmethionyl-tRNA deformylase [Pseudomonas aeruginosa 2... DEF_PSEAE - Peptide deformylase OS=Pseudomonas aeruginosa GN=def PE=1 SV=1 DEF_PSEAE - Peptide deformylase OS=Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) ... gi\|218888765, gi... - gi\|218888765\|ref\|YP_002437629.1\| peptide deformylase [Pseudomonas aeruginosa LESB58], gi\|218768988\|e... gi\|107099012 - gi\|107099012\|ref\|ZP_01362930.1\| hypothetical protein PaerPA_01000019 [Pseudomonas aeruginosa PACS2] gi\|194548724, gi... - gi\|84318294\|ref\|ZP_00966720.1\| COG0242: N-formylmethionyl-tRNA deformylase [Pseudomonas aeruginosa C...	219.0	[0..1]	[183..4]
gi\|213968425, gi... - gi\|213968425\|ref\|ZP_03396568.1\| polypeptide deformylase [Pseudomonas syringae pv. tomato T1], gi\|213... DEF1_PSESM - Peptide deformylase 1 OS=Pseudomonas syringae pv. tomato GN=def1 PE=3 SV=1 DEF1_PSESM - Peptide deformylase 1 OS=Pseudomonas syringae pv. tomato (strain DC3000) GN=def1 PE=3 SV=1	218.0	[0..1]	[180..4]

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Predicted Domain #1

Region A:
Residues: [1-209]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKIVTTDSEN KAVLYKVASE VEIPLTKTTK EKIEAMRIFY KSFQGKAGFA VPQVGLSERI  60
   61 ILVEQHLFDT TMAEETDEPT ILVNPSWRPI SDKKEWDIEG CLSVPGKVGV VERYVHVELT 120
  121 AWLYHSDTEA LSKIKREYHR EYSSVLWQHE IDHLEGKIYV DKAKLLLNEK DFYSFRQQLI 180
  181 ESGKIQSGMA LFDLGPLIYD IVVKGEIPS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	57.39794
Match:	1n5nA
Description:	Peptide deformylase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	2.58820956037645	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	2.29341894440799	bayes_pls_golite062009
peptide deformylase activity	2.09701270257336	bayes_pls_golite062009
hydrolase activity	1.74603757697733	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	1.59643176725105	bayes_pls_golite062009
formylmethionine deformylase activity	0.90550535791718	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: