YRC Public Data Repository - Protein Structure Prediction

Protein:	LPXH_COXBU
Organism:	Coxiella burnetii RSA 493
Length:	243 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LPXH_COXBU.

Description	E-value	Query Range	Subject Range
LPXH_VIBVY - UDP-2,3-diacylglucosamine hydrolase OS=Vibrio vulnificus (strain YJ016) GN=lpxH PE=3 SV=1	226.0	[0..2]	[241..1]
LPXH_VIBVU - UDP-2,3-diacylglucosamine hydrolase OS=Vibrio vulnificus GN=lpxH PE=3 SV=2 LPXH_VIBVU - UDP-2,3-diacylglucosamine hydrolase OS=Vibrio vulnificus (strain CMCP6) GN=lpxH PE=3 SV=2	225.0	[0..2]	[241..1]
LPXH_VIBPA - UDP-2,3-diacylglucosamine hydrolase OS=Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) ... LPXH_VIBPA - UDP-2,3-diacylglucosamine hydrolase OS=Vibrio parahaemolyticus GN=lpxH PE=3 SV=1	221.0	[0..2]	[242..1]
gi\|194538739, gi... - gi\|75853448\|ref\|ZP_00761304.1\| COG2908: Uncharacterized protein conserved in bacteria [Vibrio sp. Ex...	220.0	[0..2]	[241..1]
gi\|89075762, gi\|... - gi\|89075762\|ref\|ZP_01162150.1\| UDP-2,3-diacylglucosamine hydrolase [Photobacterium sp. SKA34], gi\|89...	219.0	[0..2]	[232..1]
gi\|107101223 - gi\|107101223\|ref\|ZP_01365141.1\| hypothetical protein PaerPA_01002255 [Pseudomonas aeruginosa PACS2] gi\|126166817, gi... - gi\|84321253\|ref\|ZP_00969611.1\| COG2908: Uncharacterized protein conserved in bacteria [Pseudomonas a...	218.0	[0..2]	[241..1]
LPXH_XANCP - UDP-2,3-diacylglucosamine hydrolase OS=Xanthomonas campestris pv. campestris GN=lpxH PE=3 SV=1 LPXH_XANC8 - UDP-2,3-diacylglucosamine hydrolase OS=Xanthomonas campestris pv. campestris (strain 8004) GN=lpxH P... LPXH_XANCP - UDP-2,3-diacylglucosamine hydrolase OS=Xanthomonas campestris pv. campestris (strain ATCC 33913 / DS...	218.0	[0..2]	[232..1]
gi\|90580097, gi\|... - gi\|90580097\|ref\|ZP_01235905.1\| UDP-2,3-diacylglucosamine hydrolase [Vibrio angustum S14], gi\|9043898...	218.0	[0..2]	[232..1]
gi\|49082126 - gi\|49082126\|gb\|AAT50463.1\| PA1792 [synthetic construct]	217.0	[0..2]	[241..1]
LPXH_PSEAE - UDP-2,3-diacylglucosamine hydrolase OS=Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 1... LPXH_PSEAE - UDP-2,3-diacylglucosamine hydrolase OS=Pseudomonas aeruginosa GN=lpxH PE=3 SV=1 LPXH_PSEAB - UDP-2,3-diacylglucosamine hydrolase OS=Pseudomonas aeruginosa (strain UCBPP-PA14) GN=lpxH PE=3 SV=1 gi\|84328114, gi\|... - gi\|84328114\|ref\|ZP_00976125.1\| COG2908: Uncharacterized protein conserved in bacteria [Pseudomonas a... LPXH_PSEA8 - UDP-2,3-diacylglucosamine hydrolase OS=Pseudomonas aeruginosa (strain LESB58) GN=lpxH PE=3 SV=1	217.0	[0..2]	[241..1]

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Predicted Domain #1

Region A:
Residues: [1-243]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRHTLFISDL HLEEKTPSIT AHFLYFLKHQ APKADAIYIL GDFFEAWIGD DNQTPFNRKI  60
   61 IESLQTLART KPTYFMRGNR DFLIGQRFAA MTGVSLLEDP SVIQLYNKPV LLMHGDSLCT 120
  121 LDHKHQAYRR KIMKPWVQKL MLSLPLSLRR KLAKKFREQS RRHNRTLSYE IKDVTPEEVN 180
  181 RVMKEQNVEL LIHGHTHRPA IHDLTINGNP TKRIVLGAWH HGGSVLRYAQ DGSFELQAFK 240
  241 IDL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	16.69897
Match:	1ii7A
Description:	Mre11
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.39852585255405	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	1.08477762279171	bayes_pls_golite062009
phosphoprotein phosphatase activity	1.05109559862153	bayes_pls_golite062009
protein serine/threonine phosphatase activity	0.877022343553428	bayes_pls_golite062009
phosphoric ester hydrolase activity	0.762880369401283	bayes_pls_golite062009
phosphatase activity	0.638806808750323	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: