YRC Public Data Repository - Protein Structure Prediction

Protein:	RNH_COXBU
Organism:	Coxiella burnetii RSA 493
Length:	154 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RNH_COXBU.

Description	E-value	Query Range	Subject Range
gi\|238721803, gi... - gi\|77973125\|ref\|ZP_00828677.1\| COG0328: Ribonuclease HI [Yersinia frederiksenii ATCC 33641], gi\|2387...	188.0	[0..3]	[149..4]
gi\|26246158, gi\|... - gi\|26246158\|ref\|NP_752197.1\| ribonuclease H [Escherichia coli CFT073], gi\|26106555\|gb\|AAN78741.1\|AE0...	186.0	[0..3]	[145..36]
gi\|24111645, gi\|... - gi\|24111645\|ref\|NP_706155.1\| ribonuclease H [Shigella flexneri 2a str. 301], gi\|24050418\|gb\|AAN41862...	186.0	[0..3]	[145..36]
gi\|91070856, gi\|... - gi\|91209282\|ref\|YP_539268.1\| ribonuclease H [Escherichia coli UTI89], gi\|91070856\|gb\|ABE05737.1\| RNa... gi\|117622496, gi... - gi\|117622496\|ref\|YP_851409.1\| ribonuclease H [Escherichia coli APEC O1], gi\|115511620\|gb\|ABI99694.1\|... gi\|226899001, gi... - gi\|237707791\|ref\|ZP_04538272.1\| ribonuclease H [Escherichia sp. 3_2_53FAA], gi\|226899001\|gb\|EEH85260... gi\|194419057, gi... - gi\|194432795\|ref\|ZP_03065080.1\| ribonuclease H [Shigella dysenteriae 1012], gi\|194419057\|gb\|EDX35141...	185.0	[0..3]	[145..36]
gi\|110613810, gi... - gi\|110804262\|ref\|YP_687781.1\| ribonuclease H [Shigella flexneri 5 str. 8401], gi\|110613810\|gb\|ABF024...	185.0	[0..3]	[145..36]
RNH_YERPS - Ribonuclease H OS=Yersinia pseudotuberculosis GN=rnhA PE=3 SV=1 gi\|165924761, gi... - gi\|165924761\|ref\|ZP_02220593.1\| RNase H [Yersinia pestis biovar Orientalis str. F1991016], gi\|165923... gi\|166011974, gi... - gi\|166011974\|ref\|ZP_02232872.1\| RNase H [Yersinia pestis biovar Antiqua str. E1979001], gi\|165989141... gi\|166211295, gi... - gi\|166211295\|ref\|ZP_02237330.1\| RNase H [Yersinia pestis biovar Antiqua str. B42003004], gi\|16620706... gi\|167399933, gi... - gi\|167399933\|ref\|ZP_02305451.1\| RNase H [Yersinia pestis biovar Antiqua str. UG05-0454], gi\|16705064... gi\|167419598, gi... - gi\|167419598\|ref\|ZP_02311351.1\| RNase H [Yersinia pestis biovar Orientalis str. MG05-1020], gi\|16696... gi\|167056769, gi... - gi\|167423920\|ref\|ZP_02315673.1\| RNase H [Yersinia pestis biovar Mediaevalis str. K1973002], gi\|16705... RNH_YERPY - Ribonuclease H OS=Yersinia pseudotuberculosis serotype O:3 (strain YPIII) GN=rnhA PE=3 SV=1 RNH_YERPB - Ribonuclease H OS=Yersinia pseudotuberculosis serotype IB (strain PB1/+) GN=rnhA PE=3 SV=1 gi\|21960014, gi\|... - gi\|22126971\|ref\|NP_670394.1\| ribonuclease H [Yersinia pestis KIM], gi\|21960014\|gb\|AAM86645.1\|AE01391... RNH_YERPS - Ribonuclease H OS=Yersinia pseudotuberculosis serotype I (strain IP32953) GN=rnhA PE=3 SV=1 gi\|45442536, gi\|... - gi\|45442536\|ref\|NP_994075.1\| ribonuclease H [Yersinia pestis biovar Microtus str. 91001], gi\|4543740... RNH_YERPG - Ribonuclease H OS=Yersinia pestis bv. Antiqua (strain Angola) GN=rnhA PE=3 SV=1 RNH_YERP3 - Ribonuclease H OS=Yersinia pseudotuberculosis serotype O:1b (strain IP 31758) GN=rnhA PE=3 SV=1 gi\|218928250, gi... - gi\|218928250\|ref\|YP_002346125.1\| ribonuclease H [Yersinia pestis CO92], gi\|16121382\|ref\|NP_404695.1\|... RNH_YERPE - Ribonuclease HI OS=Yersinia pestis GN=rnhA PE=3 SV=1 RNH_YERPA - Ribonuclease H OS=Yersinia pestis bv. Antiqua (strain Antiqua) GN=rnhA PE=3 SV=1 RNH_YERPN - Ribonuclease H OS=Yersinia pestis bv. Antiqua (strain Nepal516) GN=rnhA PE=3 SV=1 gi\|229841012, gi... - gi\|229841012\|ref\|ZP_04461171.1\| ribonuclease HI, degrades RNA of DNA-RNA hybrids [Yersinia pestis bi... gi\|149291290, gi... - gi\|149366916\|ref\|ZP_01888950.1\| ribonuclease HI [Yersinia pestis CA88-4125], gi\|149291290\|gb\|EDM4136... gi\|229689464, gi... - gi\|229843117\|ref\|ZP_04463263.1\| ribonuclease HI, degrades RNA of DNA-RNA hybrids [Yersinia pestis bi... gi\|165913674, gi... - gi\|89102980\|ref\|ZP_01175579.1\| COG0328: Ribonuclease HI [Yersinia pestis biovar Orientalis str. IP27... RNH_YERPP - Ribonuclease H OS=Yersinia pestis (strain Pestoides F) GN=rnhA PE=3 SV=1 gi\|229701620, gi... - gi\|229895465\|ref\|ZP_04510637.1\| ribonuclease HI, degrades RNA of DNA-RNA hybrids [Yersinia pestis Pe...	183.0	[0..5]	[149..1]
gi\|62126462, gi\|... - gi\|62178829\|ref\|YP_215246.1\| ribonuclease H [Salmonella enterica subsp. enterica serovar Choleraesui...	183.0	[0..3]	[150..118]
gi\|77957727, gi\|... - gi\|77957727\|ref\|ZP_00821775.1\| COG0328: Ribonuclease HI [Yersinia bercovieri ATCC 43970], gi\|2387848...	183.0	[0..5]	[149..1]
gi\|89075026, gi\|... - gi\|89075026\|ref\|ZP_01161471.1\| putative ribonuclease HI [Photobacterium sp. SKA34], gi\|89049265\|gb\|E...	183.0	[0..5]	[149..1]
RNH_RHIEC - Ribonuclease H OS=Rhizobium etli (strain CFN 42 / ATCC 51251) GN=rnhA PE=3 SV=1	183.0	[0..6]	[150..1]

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Predicted Domain #1

Region A:
Residues: [1-154]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKQEQNIVY LYCDGACRGN PGPGGWGVLL RYNQHERQLH GGVANTTNNQ MELTAAIEGL  60
   61 KSLKKPCQVV VTTDSQYLRR GITEWLPVWK RRGWRTSNKK PVKNQPLWET LEREVERHTI 120
  121 VWHWVKGHSG HAENEIADEL ANRGIDEVLK RGVQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	46.522879
Match:	1rbrA
Description:	STRUCTURAL STUDY OF MUTANTS OF ESCHERICHIA COLI RIBONUCLEASE HI WITH ENHANCED THERMOSTABILITY
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ribonuclease activity	3.91517707500372	bayes_pls_golite062009
endoribonuclease activity	3.00008907756136	bayes_pls_golite062009
ribonuclease H activity	2.37346218921366	bayes_pls_golite062009
hydrolase activity	2.30893115816458	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	2.26022264830742	bayes_pls_golite062009
nuclease activity	1.81796593394339	bayes_pls_golite062009
endonuclease activity	1.79009816048707	bayes_pls_golite062009
catalytic activity	1.62277843225829	bayes_pls_golite062009
exoribonuclease activity	1.48827607538468	bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters	1.34153791988846	bayes_pls_golite062009
3'-5'-exoribonuclease activity	0.8085201347205	bayes_pls_golite062009
exonuclease activity	0.39213900591465	bayes_pls_golite062009
endoribonuclease activity, producing 5'-phosphomonoesters	0.13187450705887	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: