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View Structure Prediction Details

Protein: HGNC:4281|MIM:60...
Organism: SPECIES UNKNOWN
Length: 433 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HGNC:4281|MIM:60....

Description E-value Query
Range
Subject
Range
gi|55588088 - gi|55588088|ref|XP_524857.1| PREDICTED: gap junction protein, alpha 8, 50kDa (connexin 50) [Pan trog...
0.0 [1..433] [1..433]
gi|4885275, gi|1... - gi|7441351|pir||I39176 intrinsic membrane protein MP70 - human, ref|NP_005258.1| gap junction protei...
0.0 [1..433] [1..432]
CXA8_RAT - Gap junction alpha-8 protein OS=Rattus norvegicus GN=Gja8 PE=1 SV=1
0.0 [1..433] [1..440]
gi|109015264 - gi|109015264|ref|XP_001095298.1| PREDICTED: gap junction protein, alpha 8, 50kDa (connexin 50) [Maca...
0.0 [1..433] [1..435]
CXA8_MOUSE - Gap junction alpha-8 protein OS=Mus musculus GN=Gja8 PE=1 SV=2
0.0 [1..433] [1..440]
gi|57098899 - gi|57098899|ref|XP_540274.1| PREDICTED: similar to gap junction membrane channel protein alpha 8 iso...
0.0 [1..433] [1..439]

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Predicted Domain #1
Region A:
Residues: [1-137]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGDWSFLGNI LEEVNEHSTV IGRVWLTVLF IFRILILGTA AEFVWGDEQS DFVCNTQQPG  60
   61 CENVCYDEAF PISHIRLWVL QIIFVSTPSL MYVGHAVHYV RMEEKRKSRE AEELGQQAGT 120
  121 NGGPDQGSVK KSSGSKG

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 89.823909
Match: PF00029.10
Description: No description for PF00029.10 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [138-243]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TKKFRLEGTL LRTYICHIIF KTLFEVGFIV GHYFLYGFRI LPLYRCSRWP CPNVVDCFVS  60
   61 RPTEKTIFIL FMLSVASVSL FLNVMELGHL GLKGIRSALK RPVEQP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [244-433]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LGEIPEKSLH SIAVSSIQKA KGYQLLEEEK IVSHYFPLTE VGMVETSPLP AKPFNQFEEK  60
   61 ISTGPLGDLS RGYQETLPSY AQVGAQEVEG EGPPAEEGAE PEVGEKKEEA ERLTTEEQEK 120
  121 VAVPEGEKVE TPGVDKEGEK EEPQSEKVSK QGLPAEKTPS LCPELTTDDA RPLSRLSKAS 180
  181 SRARSDDLTV 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.30103
Match: 1r5sA
Description: Connexin 43 Carboxyl Terminal Domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
gap junction channel activity 8.7394469748353 bayes_pls_golite062009
gap junction hemi-channel activity 6.07792310007804 bayes_pls_golite062009
channel activity 3.3317557399613 bayes_pls_golite062009
passive transmembrane transporter activity 3.3317557399613 bayes_pls_golite062009
transporter activity 2.93091397928047 bayes_pls_golite062009
transmembrane transporter activity 2.82224868778929 bayes_pls_golite062009
gated channel activity 2.71019001063999 bayes_pls_golite062009
molecular transducer activity 2.13986461397239 bayes_pls_golite062009
signal transducer activity 2.13986461397239 bayes_pls_golite062009
voltage-gated channel activity 2.0179028116167 bayes_pls_golite062009
substrate-specific transporter activity 1.72732246293743 bayes_pls_golite062009
PDZ domain binding 1.67572965812401 bayes_pls_golite062009
binding 1.64221234725269 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.59907041714577 bayes_pls_golite062009
ion transmembrane transporter activity 1.48329840603397 bayes_pls_golite062009
wide pore channel activity 1.20772405672681 bayes_pls_golite062009
receptor binding 0.64895976014223 bayes_pls_golite062009
protein binding 0.634982583867058 bayes_pls_golite062009
protein domain specific binding 0.49888190331002 bayes_pls_golite062009
SH3 domain binding 0.0507592042406799 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle