YRC Public Data Repository - Protein Structure Prediction

Protein:	HGNC:7330\|MIM:60...
Organism:	SPECIES UNKNOWN
Length:	362 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HGNC:7330|MIM:60....

Description	E-value	Query Range	Subject Range
MSI1H_RAT - RNA-binding protein Musashi homolog 1 OS=Rattus norvegicus GN=Msi1 PE=2 SV=1	3.0E-60	[1..362]	[1..362]
MSI1H_MOUSE - RNA-binding protein Musashi homolog 1 OS=Mus musculus GN=Msi1 PE=1 SV=1 gi\|148921876, gi... - gi\|148921876\|gb\|AAI46539.1\| Musashi homolog 1(Drosophila) [synthetic construct], gi\|147897761\|gb\|AAI...	3.0E-60	[1..362]	[1..362]
gi\|73995305 - gi\|73995305\|ref\|XP_854252.1\| PREDICTED: similar to musashi 1 [Canis familiaris]	4.0E-57	[1..362]	[1..351]
gi\|76610797 - gi\|76610797\|ref\|XP_605827.2\| PREDICTED: similar to musashi 1 [Bos taurus]	6.0E-57	[22..362]	[1..341]
gi\|148233348, gi... - gi\|214630\|gb\|AAA49919.1\| pot. RNA-binding protein (nrp-1B); putative, pir\|\|I51546 probable RNA-bindi...	7.0E-54	[1..362]	[1..347]
gi\|56970642, gi\|... - gi\|58332792\|ref\|NP_001011470.1\| musashi homolog 1 [Xenopus (Silurana) tropicalis], gi\|56970642\|gb\|AA... gi\|52221204, gi\|... - gi\|52221204\|gb\|AAH82667.1\| LOC397764 protein [Xenopus laevis], gi\|214632\|gb\|AAA49920.1\| pot. RNA-bin...	7.0E-52	[1..362]	[1..340]
gi\|60688517, gi\|... - gi\|61806598\|ref\|NP_001013534.1\| musashi homolog 1 [Danio rerio], gi\|60688517\|gb\|AAH90916.1\| Musashi ...	1.0E-48	[1..362]	[1..330]

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Predicted Domain #1

Region A:
Residues: [1-183]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 METDAPQPGL ASPDSPHDPC KMFIGGLSWQ TTQEGLREYF GQFGEVKECL VMRDPLTKRS  60
   61 RGFGFVTFMD QAGVDKVLAQ SRHELDSKTI DPKVAFPRRA QPKMVTRTKK IFVGGLSVNT 120
  121 TVEDVKQYFE QFGKVDDAML MFDKTTNRHR GFGFVTFESE DIVEKVCEIH FHEINNKMVE 180
  181 CKK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	38.69897
Match:	1pgzA
Description:	Crystal Structure of UP1 Complexed With d(TTAGGGTTAG(6-MI)G); A Human Telomeric Repeat Containing 6-methyl-8-(2-deoxy-beta-ribofuranosyl)isoxanthopteridine (6-MI)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
RNA binding	6.73097473547076	bayes_pls_golite062009
	6.62953239642182	bayes_pls_golite062009
mRNA binding	5.29759606920196	bayes_pls_golite062009
poly(U) RNA binding	4.76054718156645	bayes_pls_golite062009
nucleic acid binding	3.81920018903278	bayes_pls_golite062009
snRNA binding	3.28448936696877	bayes_pls_golite062009
poly-pyrimidine tract binding	3.11990160533699	bayes_pls_golite062009
binding	3.05116833253954	bayes_pls_golite062009
single-stranded RNA binding	2.93798024346416	bayes_pls_golite062009
U1 snRNA binding	2.26303528058407	bayes_pls_golite062009
structural molecule activity	1.29928829870122	bayes_pls_golite062009
protein binding	1.14508556628804	bayes_pls_golite062009
transcription regulator activity	1.07788694919471	bayes_pls_golite062009
DNA binding	0.978604858165557	bayes_pls_golite062009
mRNA 3'-UTR binding	0.591700155096213	bayes_pls_golite062009
transcription factor activity	0.234742017105535	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [184-362]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AQPKEVMSPT GSARGRSRVM PYGMDAFMLG IGMLGYPGFQ ATTYASRSYT GLAPGYTYQF  60
   61 PEFRVERTPL PSAPVLPELT AIPLTAYGPM AAAAAAAAVV RGTGSHPWTM APPPGSTPSR 120
  121 TGGFLGTTSP GPMAELYGAA NQDSGVSSYI SAASPAPSTG FGHSLGGPLI ATAFTNGYH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	4.154902
Match:	1m2vB
Description:	Sec24
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: