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View Structure Prediction Details

Protein: HGNC:9804|MIM:60...
Organism: SPECIES UNKNOWN
Length: 632 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HGNC:9804|MIM:60....

Description E-value Query
Range
Subject
Range
gi|76618326 - gi|76618326|ref|XP_592496.2| PREDICTED: similar to Rac GTPase activating protein 1 isoform 1 [Bos ta...
0.0 [1..632] [1..632]
gi|114644843, gi... - gi|114644863|ref|XP_001156519.1| PREDICTED: hypothetical protein isoform 8 [Pan troglodytes], gi|114...
0.0 [1..632] [1..632]
gi|109096581, gi... - gi|109096581|ref|XP_001110640.1| PREDICTED: similar to Rac GTPase activating protein 1 isoform 1 [Ma...
0.0 [1..632] [1..632]
gi|7021004 - gi|7021004|dbj|BAA91347.1| unnamed protein product [Homo sapiens]
0.0 [1..632] [1..632]
gi|73996453 - gi|73996453|ref|XP_543675.2| PREDICTED: similar to Rac GTPase activating protein 1 isoform 1 [Canis ...
0.0 [1..632] [1..632]
RGAP1_MOUSE - Rac GTPase-activating protein 1 OS=Mus musculus GN=Racgap1 PE=1 SV=1
0.0 [1..632] [1..628]

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Predicted Domain #1
Region A:
Residues: [1-159]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDTMMLNVRN LFEQLVRRVE ILSEGNEVQF IQLAKDFEDF RKKWQRTDHE LGKYKDLLMK  60
   61 AETERSALDV KLKHARNQVD VEIKRRQRAE ADCEKLERQI QLIREMLMCD TSGSIQLSEE 120
  121 QKSALAFLNR GQPSSSNAGN KRLSTIDESG SILSDISFD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.69897
Match: 1i84S
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [160-249]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KTDESLDWDS SLVKTFKLKK REKRRSTSRQ FVDGPPGPVK KTRSIGSAVD QGNESIVAKT  60
   61 TVTVPNDGGP IEAVSTIETV PYWTRSRRKT 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [250-345]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GTLQPWNSDS TLNSRQLEPR TETDSVGTPQ SNGGMRLHDF VSKTVIKPES CVPCGKRIKF  60
   61 GKLSLKCRDC RVVSHPECRD RCPLPCIPTL IGTPVK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.69897
Match: 1tbnA
Description: NMR STRUCTURE OF A PROTEIN KINASE C-G PHORBOL-BINDING DOMAIN, MINIMIZED AVERAGE STRUCTURE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.79128751898373 bayes_pls_golite062009
GTPase regulator activity 2.70614727793157 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 2.68579854252375 bayes_pls_golite062009
guanyl-nucleotide exchange factor activity 2.06038764955701 bayes_pls_golite062009
enzyme regulator activity 1.9750017471254 bayes_pls_golite062009
small GTPase regulator activity 1.95738547986197 bayes_pls_golite062009
protein binding 1.29100556128076 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.27693544428588 bayes_pls_golite062009
Ras GTPase activator activity 1.09070479183477 bayes_pls_golite062009
transcription regulator activity 1.08577758274384 bayes_pls_golite062009
Ras guanyl-nucleotide exchange factor activity 0.958295643211986 bayes_pls_golite062009
GTPase activator activity 0.717730683557543 bayes_pls_golite062009
nucleic acid binding 0.480348726111787 bayes_pls_golite062009
DNA binding 0.418154636457321 bayes_pls_golite062009
enzyme activator activity 0.298334474872045 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [346-548]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IGEGMLADFV SQTSPMIPSI VVHCVNEIEQ RGLTETGLYR ISGCDRTVKE LKEKFLRVKT  60
   61 VPLLSKVDDI HAICSLLKDF LRNLKEPLLT FRLNRAFMEA AEITDEDNSI AAMYQAVGEL 120
  121 PQANRDTLAF LMIHLQRVAQ SPHTKMDVAN LAKVFGPTIV AHAVPNPDPV TMLQDIKRQP 180
  181 KVVERLLSLP LEYWSQFMMV EQE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 42.09691
Match: 2ovjA
Description: No description for 2ovjA was found.

Predicted Domain #5
Region A:
Residues: [549-632]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NIDPLHVIEN SNAFSTPQTP DIKVSLLGPV TTPEHQLLKT PSSSSLSQRV RSTLTKNTPR  60
   61 FGSKSKSATN LGRQGNFFAS PMLK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle