YRC Public Data Repository - Protein Structure Prediction

Protein:	GCH1_SHEON
Organism:	Shewanella oneidensis MR-1
Length:	216 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GCH1_SHEON.

Description	E-value	Query Range	Subject Range
gi\|73963003 - gi\|73963003\|ref\|XP_851883.1\| PREDICTED: similar to GTP cyclohydrolase I (GTP-CH-I) isoform 1 [Canis ...	320.0	[0..2]	[216..38]
gi\|75702476, gi\|... - gi\|75908751\|ref\|YP_323047.1\| GTP cyclohydrolase I [Anabaena variabilis ATCC 29413], gi\|75702476\|gb\|A...	319.0	[0..2]	[216..15]
gi\|255061 - gi\|255061\|gb\|AAB23164.1\| GTP cyclohydrolase I [Homo sapiens]	318.0	[0..2]	[216..30]
gi\|25290301 - pir\|\|AG2466 GTP cyclohydrolase I [imported] - Nostoc sp. (strain PCC 7120) GCH11_NOSS1 - GTP cyclohydrolase 1 1 OS=Nostoc sp. (strain PCC 7120 / UTEX 2576) GN=folE1 PE=3 SV=1	316.0	[0..2]	[216..15]
GCH1_NOSP7 - GTP cyclohydrolase 1 OS=Nostoc punctiforme (strain ATCC 29133 / PCC 73102) GN=folE PE=3 SV=1	316.0	[0..2]	[216..15]
gi\|109083691 - gi\|109083691\|ref\|XP_001087365.1\| PREDICTED: GTP cyclohydrolase 1 (dopa-responsive dystonia) isoform ...	315.0	[0..2]	[216..39]
gi\|13272331 - gi\|13272331\|gb\|AAK17098.1\|AF288421_1 N-terminal truncated GTP cyclohydrolase I [synthetic construct]	311.0	[0..5]	[216..2]
gi\|46118361, gi\|... - gi\|67925134\|ref\|ZP_00518508.1\| GTP cyclohydrolase I [Crocosphaera watsonii WH 8501], gi\|67853028\|gb\|...	310.0	[0..17]	[216..39]

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Predicted Domain #1

Region A:
Residues: [1-216]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPLSEAAVKV QAALQERGLE TPMLPSVFTP EERKDKIEHH MKEILTLMSL DLSDDSLADT  60
   61 PRRIAKMYVD EIFSGLDYAN FPKITVIDNK MGFDEMVRVQ DISLTSTCEH HLVTIDGTAT 120
  121 IAYLPRKKII GLSKINRIVR FFAQRPQVQE RLTQQVLVAL QTLLETKDVA VKMDAVHYCV 180
  181 KSRGVMDSTS STTTTALGGI FKSNPATRAE FLHQSK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	74.045757
Match:	1fbxA
Description:	GTP cyclohydrolase I
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
GTP cyclohydrolase I activity	4.1430878480831	bayes_pls_golite062009
cyclohydrolase activity	3.66553359909123	bayes_pls_golite062009
GTP cyclohydrolase activity	3.44912994722205	bayes_pls_golite062009
catalytic activity	2.20788162511962	bayes_pls_golite062009
dihydroneopterin aldolase activity	1.96466418682643	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	1.73101699306211	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	0.974891318710762	bayes_pls_golite062009
binding	0.392476729829125	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: