YRC Public Data Repository - Protein Structure Prediction

Protein:	GUAA_SHEON
Organism:	Shewanella oneidensis MR-1
Length:	525 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GUAA_SHEON.

Description	E-value	Query Range	Subject Range
GUAA_SALTY - GMP synthase [glutamine-hydrolyzing] OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)... GUAA_SALTY - GMP synthase [glutamine-hydrolyzing] OS=Salmonella typhimurium GN=guaA PE=3 SV=1 GUAA_SALTY - GMP synthase [glutamine-hydrolyzing] OS=Salmonella typhimurium GN=guaA PE=3 SV=1	571.0	[0..1]	[525..1]
GUAA_SALPA - GMP synthase [glutamine-hydrolyzing] OS=Salmonella paratyphi A (strain ATCC 9150 / SARB42) GN=guaA P... GUAA_SALCH - GMP synthase [glutamine-hydrolyzing] OS=Salmonella choleraesuis (strain SC-B67) GN=guaA PE=3 SV=1 GUAA_SALCH - GMP synthase [glutamine-hydrolyzing] OS=Salmonella choleraesuis GN=guaA PE=3 SV=1 GUAA_SALPA - GMP synthase [glutamine-hydrolyzing] OS=Salmonella paratyphi A GN=guaA PE=3 SV=1 GUAA_SALPC - GMP synthase [glutamine-hydrolyzing] OS=Salmonella paratyphi C (strain RKS4594) GN=guaA PE=3 SV=1 gi\|204929457, gi... - gi\|204929457\|ref\|ZP_03220531.1\| gmp synthase (glutamine-hydrolyzing) [Salmonella enterica subsp. ent... GUAA_SALCH - GMP synthase [glutamine-hydrolyzing] OS=Salmonella choleraesuis GN=guaA PE=3 SV=1 GUAA_SALPK - GMP synthase [glutamine-hydrolyzing] OS=Salmonella paratyphi A (strain AKU_12601) GN=guaA PE=3 SV=1 gi\|197243850, gi... - gi\|197265595\|ref\|ZP_03165669.1\| gmp synthase (glutamine-hydrolyzing) [Salmonella enterica subsp. ent... gi\|168466744, gi... - gi\|195630797\|gb\|EDX49389.1\| gmp synthase (glutamine-hydrolyzing) [Salmonella enterica subsp. enteric... gi\|205329878, gi... - gi\|205329878\|gb\|EDZ16642.1\| gmp synthase (glutamine-hydrolyzing) [Salmonella enterica subsp. enteric... GUAA_SALPB - GMP synthase [glutamine-hydrolyzing] OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=guaA... GUAA_SALPB - GMP synthase [glutamine-hydrolyzing] OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=guaA... lcl\|NC_016856.1_... - [gene=guaA] [protein=bifunctional GMP synthase/glutamine amidotransferase protein] [protein_id=YP_00...	570.0	[0..1]	[525..1]
gi\|213425340 - gi\|213425340\|ref\|ZP_03358090.1\| bifunctional GMP synthase/glutamine amidotransferase protein [Salmon... gi\|213622893 - gi\|213622893\|ref\|ZP_03375676.1\| bifunctional GMP synthase/glutamine amidotransferase protein [Salmon... gi\|213852551 - gi\|213852551\|ref\|ZP_03382083.1\| bifunctional GMP synthase/glutamine amidotransferase protein [Salmon... gi\|238913647 - gi\|238913647\|ref\|ZP_04657484.1\| GMP synthase [Salmonella enterica subsp. enterica serovar Tennessee ... gi\|214000302 - gi\|214000302\|ref\|ZP_03411037.1\| bifunctional GMP synthase/glutamine amidotransferase protein [Salmon... GUAA_SALDC - GMP synthase [glutamine-hydrolyzing] OS=Salmonella dublin (strain CT_02021853) GN=guaA PE=3 SV=1 GUAA_SALG2 - GMP synthase [glutamine-hydrolyzing] OS=Salmonella gallinarum (strain 287/91 / NCTC 13346) GN=guaA P... GUAA_SALEP - GMP synthase [glutamine-hydrolyzing] OS=Salmonella enteritidis PT4 (strain P125109) GN=guaA PE=3 SV=... gi\|213160878 - gi\|213160878\|ref\|ZP_03346588.1\| bifunctional GMP synthase/glutamine amidotransferase protein [Salmon... GUAA_SALTI - GMP synthase [glutamine-hydrolyzing] OS=Salmonella typhi GN=guaA PE=3 SV=1 gi\|205344986, gi... - gi\|205344986\|gb\|EDZ31750.1\| gmp synthase (glutamine-hydrolyzing) [Salmonella enterica subsp. enteric... GUAA_SALHS - GMP synthase [glutamine-hydrolyzing] OS=Salmonella heidelberg (strain SL476) GN=guaA PE=3 SV=1 gi\|194470386, gi... - gi\|194470386\|ref\|ZP_03076370.1\| gmp synthase (glutamine-hydrolyzing) [Salmonella enterica subsp. ent... GUAA_SALA4 - GMP synthase [glutamine-hydrolyzing] OS=Salmonella agona (strain SL483) GN=guaA PE=3 SV=1 gi\|205325488, gi... - gi\|205325488\|gb\|EDZ13327.1\| gmp synthase (glutamine-hydrolyzing) [Salmonella enterica subsp. enteric... gi\|168232074, gi... - gi\|205333635\|gb\|EDZ20399.1\| gmp synthase (glutamine-hydrolyzing) [Salmonella enterica subsp. enteric... gi\|168243285, gi... - gi\|205337568\|gb\|EDZ24332.1\| gmp synthase (glutamine-hydrolyzing) [Salmonella enterica subsp. enteric... gi\|205349448, gi... - gi\|205349448\|gb\|EDZ36079.1\| gmp synthase (glutamine-hydrolyzing) [Salmonella enterica subsp. enteric... gi\|29140876, gi\|... - gi\|29140876\|ref\|NP_804218.1\| bifunctional GMP synthase/glutamine amidotransferase protein [Salmonell... gi\|16761427 - gi\|16761427\|ref\|NP_457044.1\| bifunctional GMP synthase/glutamine amidotransferase protein [Salmonell... GUAA_SALTI - GMP synthase [glutamine-hydrolyzing] OS=Salmonella typhi GN=guaA PE=3 SV=1	570.0	[0..1]	[525..1]
GUAA_SHIB3 - GMP synthase [glutamine-hydrolyzing] OS=Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) GN=...	568.0	[0..1]	[525..1]
GUAA_SHISS - GMP synthase [glutamine-hydrolyzing] OS=Shigella sonnei (strain Ss046) GN=guaA PE=3 SV=1	568.0	[0..1]	[525..1]
gi\|53732885 - gi\|53732885\|ref\|ZP_00155220.2\| COG0519: GMP synthase, PP-ATPase domain/subunit [Haemophilus influenz...	568.0	[0..1]	[525..1]
GUAA_SHIBS - GMP synthase [glutamine-hydrolyzing] OS=Shigella boydii serotype 4 (strain Sb227) GN=guaA PE=3 SV=1	568.0	[0..1]	[525..1]
gi\|195936649 - gi\|195936649\|ref\|ZP_03082031.1\| bifunctional GMP synthase/glutamine amidotransferase protein [Escher... gi\|208728135, gi... - gi\|208808334\|ref\|ZP_03250671.1\| GMP synthetase [Escherichia coli O157:H7 str. EC4206], gi\|208728135\|... gi\|208812438, gi... - gi\|208812438\|ref\|ZP_03253767.1\| GMP synthetase [Escherichia coli O157:H7 str. EC4045], gi\|208733715\|... gi\|208819837, gi... - gi\|208819837\|ref\|ZP_03260157.1\| GMP synthetase [Escherichia coli O157:H7 str. EC4042], gi\|208739960\|... GUAA_ECO5E - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=guaA PE=3... GUAA_ECOSE - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli (strain SE11) GN=guaA PE=3 SV=1 gi\|194432074, gi... - gi\|83570727\|ref\|ZP_00922170.1\| COG0519: GMP synthase, PP-ATPase domain/subunit [Shigella dysenteriae... gi\|217327698, gi... - gi\|217327698\|ref\|ZP_03443781.1\| GMP synthetase [Escherichia coli O157:H7 str. TW14588], gi\|217320065... GUAA_ECOHS - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli O9:H4 (strain HS) GN=guaA PE=3 SV=1 GUAA_ECO8A - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli O8 (strain IAI1) GN=guaA PE=3 SV=1 gi\|168761118, gi... - gi\|189368390\|gb\|EDU86806.1\| GMP synthase [Escherichia coli O157:H7 str. EC4501], gi\|168761118\|ref\|ZP... gi\|189362273, gi... - gi\|189362273\|gb\|EDU80692.1\| GMP synthase [Escherichia coli O157:H7 str. EC4486], gi\|168768599\|ref\|ZP... gi\|254794453, gi... - gi\|254794453\|ref\|YP_003079290.1\| GMP synthetase (glutamine aminotransferase) [Escherichia coli O157:... gi\|168773579, gi... - gi\|187770635\|gb\|EDU34479.1\| GMP synthase (glutamine-hydrolyzing) [Escherichia coli O157:H7 str. EC41... gi\|237705014, gi... - gi\|237705014\|ref\|ZP_04535495.1\| bifunctional GMP synthase/glutamine amidotransferase [Escherichia sp... gi\|168778473, gi... - gi\|189003283\|gb\|EDU72269.1\| GMP synthase [Escherichia coli O157:H7 str. EC4076], gi\|168778473\|ref\|ZP... gi\|227835889, gi... - gi\|227887539\|ref\|ZP_04005344.1\| bifunctional GMP synthase/glutamine amidotransferase protein [Escher... GUAA_ECOUT - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli (strain UTI89 / UPEC) GN=guaA PE=3 SV=1 gi\|168787853, gi... - gi\|189372276\|gb\|EDU90692.1\| GMP synthase [Escherichia coli O157:H7 str. EC869], gi\|168787853\|ref\|ZP_... gi\|13362839, gi\|... - gi\|15832623\|ref\|NP_311396.1\| GMP synthase [Escherichia coli O157:H7 str. Sakai], gi\|13362839\|dbj\|BAB... gi\|168798878, gi... - gi\|189378613\|gb\|EDU97029.1\| GMP synthase [Escherichia coli O157:H7 str. EC508], gi\|168798878\|ref\|ZP_... GUAA_ECOL5 - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=guaA PE=3... GUAA_ECOLC - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks) GN=g... GUAA_ECOSM - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli (strain SMS-3-5 / SECEC) GN=guaA PE=3 SV=1 GUAA_ECO45 - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=guaA PE=3 SV... GUAA_ECO81 - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli O81 (strain ED1a) GN=guaA PE=3 SV=1 GUAA_ECO55 - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli (strain 55989 / EAEC) GN=guaA PE=3 SV=1 GUAA_ECO7I - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli O7:K1 (strain IAI39 / ExPEC) GN=guaA PE=3 S... GUAA_ECOL6 - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli O6 GN=guaA PE=3 SV=1 GUAA_ECO57 - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli O157:H7 GN=guaA PE=3 SV=1 gi\|209763452, gi... - pir\|\|A91050 GMP synthetase [imported] - Escherichia coli (strain O157:H7, substrain RIMD 0509952), ... GUAA_ECOL6 - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) ... gi\|168748434, gi... - gi\|188017013\|gb\|EDU55135.1\| GMP synthase [Escherichia coli O157:H7 str. EC4113], gi\|168748434\|ref\|ZP... gi\|189356551, gi... - gi\|189356551\|gb\|EDU74970.1\| GMP synthase [Escherichia coli O157:H7 str. EC4401], gi\|168756279\|ref\|ZP... gi\|194414657, gi... - gi\|75211473\|ref\|ZP_00711563.1\| COG0519: GMP synthase, PP-ATPase domain/subunit [Escherichia coli B17... gi\|190902261, gi... - gi\|75229161\|ref\|ZP_00715733.1\| COG0519: GMP synthase, PP-ATPase domain/subunit [Escherichia coli B7A... gi\|75237747, gi\|... - gi\|75237747\|ref\|ZP_00721763.1\| COG0519: GMP synthase, PP-ATPase domain/subunit [Escherichia coli E11... gi\|190906762, gi... - gi\|75240144\|ref\|ZP_00724103.1\| COG0519: GMP synthase, PP-ATPase domain/subunit [Escherichia coli F11... gi\|75257314, gi\|... - gi\|75257314\|ref\|ZP_00728838.1\| COG0519: GMP synthase, PP-ATPase domain/subunit [Escherichia coli E22... gi\|188491634, gi... - gi\|75515847\|ref\|ZP_00737982.1\| COG0519: GMP synthase, PP-ATPase domain/subunit [Escherichia coli 536... GUAA_ECOK1 - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli O1:K1 / APEC GN=guaA PE=3 SV=1 gi\|124498700, gi... - gi\|124531254\|ref\|ZP_01701596.1\| GMP synthase, large subunit [Escherichia coli B], gi\|124498700\|gb\|EA...	568.0	[0..1]	[525..1]
GUAA_SHIF8 - GMP synthase [glutamine-hydrolyzing] OS=Shigella flexneri serotype 5b (strain 8401) GN=guaA PE=3 SV=...	567.0	[0..1]	[525..1]
GUAA_ECO24 - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli O139:H28 (strain E24377A / ETEC) GN=guaA PE...	567.0	[0..1]	[525..1]

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Predicted Domain #1

Region A:
Residues: [1-525]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDIHEHKIL ILDFGSQYTQ LIARRIREIG VYCELWAWDV TEAQIREFAP NGIILAGGPE  60
   61 SVTADNSPRA PEYVFNAGVP VLGICYGMQT MSEQLGGKVI QGVGEGEFGY AQIEMLAESA 120
  121 LFKGIEDAVS SDGKSLLDVW MSHGDKVSAI PAGFVAVAKT DTCPFAAMSC EEKRFYGVQF 180
  181 HPEVTHTRQG MRMLSHFALD ICGCAANWKP SSIIEDAIER LKKQVGDDEV ILGLSGGVDS 240
  241 SVVAMLLHRA IGKKLTCVFV DNGLLRLNEA KQVMEMFGDH FGLNIVHVDA ENRFLDALKG 300
  301 EADPEAKRKI IGRVFVEIFD EEAKKCVNAK WLAQGTIYPD VIESAGSATG KAHVIKSHHN 360
  361 VGGLPDDMEL GLVEPLRELF KDEVRKIGLE LGLPYNMLYR HPFPGPGLGV RVLGEVKKEY 420
  421 CDLLRRADAI FIEELHKADL YNKVSQAFTV FLPVRSVGVM GDGRKYDWVV SLRAVETIDF 480
  481 MTAHWAHLPY DFLGRVSNRI INEVDGISRV VYDISGKPPA TIEWE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	162.0
Match:	1gpmA
Description:	GMP synthetase; GMP synthetase, central domain; GMP synthetase C-terminal dimerisation domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
carbon-nitrogen ligase activity, with glutamine as amido-N-donor	2.70451256281397	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	2.33781404450996	bayes_pls_golite062009
phosphoribosylformylglycinamidine synthase activity	1.83575136996743	bayes_pls_golite062009
carbamoyl-phosphate synthase activity	1.74828881793189	bayes_pls_golite062009
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	1.74029540439985	bayes_pls_golite062009
ligase activity	1.70348758031146	bayes_pls_golite062009
catalytic activity	1.30391542469987	bayes_pls_golite062009
GMP synthase activity	0.413068109408727	bayes_pls_golite062009
anthranilate synthase activity	0.243205818526006	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: