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View Structure Prediction Details

Protein: HIS6_SHEON
Organism: Shewanella oneidensis MR-1
Length: 257 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HIS6_SHEON.

Description E-value Query
Range		 Subject
Range
HIS6_CUPMC - Imidazole glycerol phosphate synthase subunit HisF OS=Cupriavidus metallidurans (strain ATCC 43123 /...
 229.0 [0..1] [256..1]
HIS6_NITEC - Imidazole glycerol phosphate synthase subunit HisF OS=Nitrosomonas eutropha (strain C91) GN=hisF PE=...
 229.0 [0..2] [256..3]
HIS6_NITEU - Imidazole glycerol phosphate synthase subunit HisF OS=Nitrosomonas europaea GN=hisF PE=3 SV=1
HIS6_NITEU - Imidazole glycerol phosphate synthase subunit HisF OS=Nitrosomonas europaea (strain ATCC 19718 / NBR...
 229.0 [0..2] [256..3]
HIS6_DESHD - Imidazole glycerol phosphate synthase subunit HisF OS=Desulfitobacterium hafniense (strain DCB-2 / D...
 229.0 [0..1] [257..1]
HIS6_GEODF - Imidazole glycerol phosphate synthase subunit HisF OS=Geobacter daltonii (strain DSM 22248 / JCM 158...
 228.0 [0..1] [256..1]
HIS6_PELTS - Imidazole glycerol phosphate synthase subunit HisF OS=Pelotomaculum thermopropionicum (strain DSM 13...
 228.0 [0..1] [256..1]
HIS6_DESHY - Imidazole glycerol phosphate synthase subunit HisF OS=Desulfitobacterium hafniense (strain Y51) GN=h...
 228.0 [0..1] [257..2]
HIS6_GEOUR - Imidazole glycerol phosphate synthase subunit HisF OS=Geobacter uraniireducens (strain Rf4) GN=hisF ...
 227.0 [0..1] [256..1]
HIS6_THETN - Imidazole glycerol phosphate synthase subunit hisF OS=Thermoanaerobacter tengcongensis GN=hisF PE=3 ...
HIS6_CALS4 - Imidazole glycerol phosphate synthase subunit HisF OS=Caldanaerobacter subterraneus subsp. tengconge...
 227.0 [0..1] [256..1]
HIS6_CUPNH - Imidazole glycerol phosphate synthase subunit HisF OS=Cupriavidus necator (strain ATCC 17699 / H16 /...
 227.0 [0..1] [256..1]

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Predicted Domain #1
Region A:
Residues: [1-257] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLAKRIVPCL DVKDGCVVKG VQFRNHEIVG DIVPLAARYA AEGADELVFY DITASAHDRV  60
   61 VDKSWVSRVA EQIDIPFCVA GGIKTITQAR ELLAFGADKI SVNSPALSDP SLISRLQDEF 120
  121 GRQCIVIGID SFYDAASDSY KVKQFTGDEA ATKETAWYTQ DWVEEVQKRG CGEIVLNVMN 180
  181 QDGVRGGYDI KQLSLVRQLC DVPLIASGGA GTMAHFRDVF IDAKVDAALA ASVFHKAIIN 240
  241 IGELKQYLAA EGIAIRR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 47.154902
Match: 1thfD
Description: Cyclase subunit (or domain) of imidazoleglycerolphosphate synthase HisF
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
imidazoleglycerol-phosphate synthase activity 8.63799159510181 bayes_pls_golite062009
catalytic activity 2.44231061702877 bayes_pls_golite062009
transferase activity, transferring pentosyl groups 1.13340776845419 bayes_pls_golite062009
indole-3-glycerol-phosphate synthase activity 0.549444136526559 bayes_pls_golite062009
tryptophan synthase activity 0.426391242491024 bayes_pls_golite062009
lyase activity 0.258652421339738 bayes_pls_golite062009
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