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View Structure Prediction Details

Protein: TPMT_SHEON
Organism: Shewanella oneidensis MR-1
Length: 218 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TPMT_SHEON.

Description E-value Query
Range		 Subject
Range
TPMT_PSESM - Thiopurine S-methyltransferase OS=Pseudomonas syringae pv. tomato GN=tpm PE=3 SV=1
TPMT_PSESM - Thiopurine S-methyltransferase OS=Pseudomonas syringae pv. tomato (strain DC3000) GN=tpm PE=3 SV=1
 138.0 [0..1] [218..1]
gi|2454197 - gi|2454197|gb|AAB71630.1| thiopurine methyltransferase [Homo sapiens]
 135.0 [0..4] [218..27]
TPMT_RAT - Thiopurine S-methyltransferase OS=Rattus norvegicus GN=Tpmt PE=2 SV=1
 134.0 [0..4] [218..22]
TPMT_GORGO - Thiopurine S-methyltransferase OS=Gorilla gorilla gorilla GN=TPMT PE=2 SV=1
 133.0 [0..4] [218..27]
TPMT_PSEPF - Thiopurine S-methyltransferase OS=Pseudomonas fluorescens (strain Pf0-1) GN=tpm PE=3 SV=1
 133.0 [0..1] [216..1]
gi|91191445, gi|... - gi|91223953|ref|ZP_01259217.1| thiopurine methyltransferase [Vibrio alginolyticus 12G01], gi|9119144...
 132.0 [0..2] [216..29]
TPMT_PANTR - Thiopurine S-methyltransferase OS=Pan troglodytes GN=TPMT PE=2 SV=1
 132.0 [0..4] [218..27]

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Predicted Domain #1
Region A:
Residues: [1-218] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEPGFWHEKW QQQQIGFHQQ DVNPFLVTYW HQLALPADAK IFVPLCGKSL DMCFLAEQGH  60
   61 QVIGCELNEL AVQQFFSDNQ LPMQQSAEGE HQHYQTEQIS LYQGDIFTLP QSITAEVSGF 120
  121 YDRAALIAWP ESMRAQYAKQ LAYLLPQGSV GLLVTLDYPQ EVLSGPPFAV SPTWVETHLS 180
  181 EDFEIQPLAC QDVLADNPRF VKKAVPWLNE AVYLLKRR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 26.09691
Match: 1pjzA
Description: Solution structure of thiopurine methyltransferase from Pseudomonas syringae
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
thiopurine S-methyltransferase activity 2.46265304635007 bayes_pls_golite062009
transferase activity 1.77671966857605 bayes_pls_golite062009
catalytic activity 1.25333584501255 bayes_pls_golite062009
methyltransferase activity 1.06467956103007 bayes_pls_golite062009
transferase activity, transferring one-carbon groups 1.04881630872808 bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity 0.663101162414044 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle